Bossaller, C.C.BossallerFleck, E.E.FleckFörstermann, U.U.FörstermannHertel, R.F.R.F.HertelOlbricht, C.C.OlbrichtReschke, V.V.Reschke2022-03-022022-03-021989https://publica.fraunhofer.de/handle/publica/176882Aortic rings dissected from rats treated with ciclosporin A showed reduced relaxation induced by the endothelium dependent vasolidator acetylcholine, but unchanged responses induced by glyceryl trinitrate. After eight weeks of ciclosporin A treatment, the relaxation induced by both acetylcholine and glyceryl trinitrate was inhibited. In addition, phenylephrine-induced contractions were slightly enhanced and vascular prostacyclin production was reduced by more than 80%. These effects may participate in the hypertensive and thrombo-embolic complications associated with the clinical use of ciclosporin A.en6-keto-PGF 1AcetylcholineAortaCiclosporin ACyclosporin AEndotheliumGlycery trinitrateradioimmunoassayrat615610620journal article