Thieben, FlorianFlorianThiebenMohn, FabianFabianMohnFoerger, FynnFynnFoergerHackelberg, NiklasNiklasHackelbergScheel, Jan-PhilippJan-PhilippScheelGraeser, MatthiasMatthiasGraeserKnopp, TobiasTobiasKnopp2023-10-102023-10-102023https://publica.fraunhofer.de/handle/publica/45153810.18416/IJMPI.2023.23030452-s2.0-85151472046Magnetic Particle Imaging hardware has reached human scale and thus patient safety questions and clinical application scenarios are in the focus of current research. In this work, we present a safe real-time 3D MPI system for cerebral applications. High voltages are avoided to ensure patient safety by a low voltage-high current transmit coil design. The developed 2D drive-field generator generates a field-free-point trajectory in the sagittal xz-plane that is shifted with low frequency by a dynamic selection-field sequence along the y-axis. The scanner generates 3D images with 4 frames/second and allows for direct visualization of the clinically preferred transversal yz-plane, which is crucial for future brain examinations. Advanced reconstruction techniques reach a system sensitivity of 4 µgFe with respect to the iron mass in a sensitivity study.enjournal article