Bartsch, W.W.BartschKraus, R.R.KrausSpiteller, G.G.Spiteller2022-03-032022-03-031991https://publica.fraunhofer.de/handle/publica/179591Aqueous-methanolic extracts from roots of Urtica dioica were fractionated and tested for aromatase- inhibition activity. After derivatization the most active fraction was separated by GC/ MS. Besides common fatty acids (10E,12Z)-9-hydroxy-10,12 octadecadienoic acid (1) was identified as a main component and confirmed to be the active principle. Lipoxygenase from tomatoes was used for synthesis of (9S)-1, which caused also inhibition of aromatase. Stereo models of the compound showed some structural similarity to steroidal natural substrates of aromatase. For that reason (IOE,12Z)-9-oxo-10,12- octadecadienoic acid (2) was also synthesized. It showed an about tenfold higher activity compared to 1.dearomatase inhibitionAromatasehemmungBrennesselwurzelextrakthydroxy fatty acidHydroxyfettsäureroot extractstinging mettle root extractUrtica dioicaWurzelextrakt615610620547journal article