Rehm, Thomas H.Thomas H.RehmHofmann, ChristianChristianHofmannReinhard, DorotheeDorotheeReinhardKost, Hans-JoachimHans-JoachimKostLöb, PatrickPatrickLöbBesold, MatthiasMatthiasBesoldWelzel, KnutKnutWelzelBarten, JanJanBartenDidenko, AndreyAndreyDidenkoSevenard, Dmitri V.Dmitri V.SevenardLix, BruceBruceLixHillson, Andrew R.Andrew R.HillsonRiegel, Susanne D.Susanne D.Riegel2022-03-052022-03-052017https://publica.fraunhofer.de/handle/publica/24809610.1039/c7re00023eA compact lab plant was designed for the continuous-flow synthesis of fluorine-containing compounds and was combined with an NMR analysis platform based on a benchtop NMR spectrometer. The approach of a unified synthesis and analysis strategy for fine chemicals was applied to three different reactions, all employing fluorine as a chemical probe for online-19F NMR analysis. A high temperature synthesis for the deprotection of a CF2H group was done as well as Ruppert-Prakash reactions for the perfluoroalkylation of benzaldehyde as a model substrate. The C-H arylation of furan with a trifluoromethylated aryldiazonium salt was performed as an example of a photochemically catalyzed reaction. All three reaction classes challenge the synthesis and analysis setup differently according to sample preparation (premagnetization of bubble-free sample) and spectrometer sensitivity (signal to noise ratio, spectral resolution, scan number, substrate concentration and flow rate), but nonetheless prove the successful application of the continuous-flow synthesis of fluorinated fine chemicals with integrated online NMR analysis.en660journal article