Lai, ChentingChentingLaiMesserschmidt, BernhardBernhardMesserschmidtReichwald, KarlKarlReichwaldFlämig, SvenSvenFlämigEidam, TinoTinoEidamStutzki, FabianFabianStutzkiCalvarese, MatteoMatteoCalvareseBae, HyeonsooHyeonsooBaeMeyer-Zedler, TobiasTobiasMeyer-ZedlerSchmitt, MichaelMichaelSchmittGross, HerbertHerbertGrossHoffmann, FranziskaFranziskaHoffmannGuntinas-Lichius, OrlandoOrlandoGuntinas-LichiusPopp, Jürgen R.Jürgen R.Popp2023-09-122023-09-122023https://publica.fraunhofer.de/handle/publica/45057210.1117/12.26500812-s2.0-85159783205Here, we present a new handheld multiphoton endomicroscopic system for tumor diagnosis in the head and neck region. It consists of an approx. 25 cm long rigid endomicroscopic probe with two variants (0° and 45° bended tip), connected to a handheld scan-head. The system can achieve a field of view > 600 µm for coherent anti-Stokes Raman scattering (CARS) and other nonlinear imaging techniques by a non-descanned detection channel, and laser confocal imaging with indocyanine green (ICG) by a descanned detection channel. Furthermore, high-power femtosecond laser pulses can be transmitted through the system for precise tissue ablation without the risk of damaging the optical components.enCARS and multiphoton endoscopyfs laser ablationindocyanine green imaginglaryngeal cancernon-linear endomicroscopyconference paper