Under CopyrightSauer, O.O.SauerSchleipen, MiriamMiriamSchleipenAmmermann, C.C.Ammermann2022-03-113.11.20102010https://publica.fraunhofer.de/handle/publica/36729110.24406/publica-fhg-367291Digital Factory Operation extends existing methods of the Digital Factory. This goes from the assistance of planning activities to the usage during plant operation. Methods and tools of the Digital Factory Operation and their efficient usage are explained. The contribution gives an overview of the contents of the VDI guideline 4499 - Part 2 and puts the results of the cooperation between research and industry up for discussion.de004670conference paper