Gruber-Traub, C.C.Gruber-TraubBurger-Kentischer, A.A.Burger-KentischerGretzinger, S.S.GretzingerHirth, ThomasThomasHirthWeber, A.A.Weber2022-03-112022-03-112012https://publica.fraunhofer.de/handle/publica/37611110.1002/cite.201100191The formulation and oral application of therapeutic petides and proteins is still a challenge due to the proteolytic gastritic degradation and the poor adsorption mechanism out of the gut lumen. A particulate chitosan-based formulation of Interferon--1b was prepared for the future oral administration using a spray drying process. The quantification of the biological activity of Interferon--1b was carried out by means of an Anti Viral Assay (AVA) and an ELISA. The activity test showed no loss of the biological activity of Interferon after the manufacturing process.de660conference paper