Köppen, JanettJanettKöppenSchilling, StephanStephanSchillingSchulze, AnjaAnjaSchulzeRahfeld, Jens-UlrichJens-UlrichRahfeldWermann, MichaelMichaelWermannKleinschmidt, MartinMartinKleinschmidtCynis, HolgerHolgerCynis2024-04-042024-04-042023-12-27https://publica.fraunhofer.de/handle/publica/465754Transthyretin amyloidosis is characterized by progressive deposition of the plasma protein transthyretin in the myocardium, peripheral nerves and/or other tissues, which can ultimately lead to congestive heart failure, polyneuropathy and death. The present invention provides binding proteins that can specifically bind to an isoaspartate residue in a transthyretin protein as well as their therapeutic, diagnostic and prognostic uses.enAnti-transthyretin (ttr) binding proteins and uses thereofAnti-Transthyretin(ttr)-bindende Proteine und ihre VerwendungenpatentEP4296279 A1EP20220180706