Kentsch, J.J.KentschDürr, M.M.DürrSchnelle, T.T.SchnelleGradl, G.G.GradlMüller, T.T.MüllerJäger, M.M.JägerNormann, A.A.NormannStelzle, M.M.Stelzle2022-03-032022-03-032003https://publica.fraunhofer.de/handle/publica/20529010.1049/ip-nbt:20031127Microfabrication and performance of a novel microsystem for separation, accumulation and analysis of biological micro- and nanoparticles is reported. Versatile chip functions based on dielectrophoresis and microfluidics were integrated to isolate particles from complex sample solutions such as serum. A bead-based assay for virus detection is proposed. Separation of micro-and sub-m beads employing dielectrophoretic deflector and bandpass structures is demonstrated. Individual antibody coated beads with hepatitis A virus bound to their surface were trapped by negative dielectrophoresis in a field cage and analysed by fluorescence microscopy.en610660journal article