The EBNA2-related resistance towards Alpha interferon -IFN-alpha- in Burkitt's lymphoma cells effects induction of IFN-induced genes but not the activation of transcription factor ISGF-3

Aman, P.P.AmanDecker, T.T.DeckerGabain, A. vonA. vonGabainKallin, B.B.KallinKanda, K.K.KandaWahlström, M.M.Wahlström2022-03-032022-03-031992https://publica.fraunhofer.de/handle/publica/181191Transfection of a plasmid encoding the Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) gene confers resistance to the antiproliferative effect of alpha interferon in EBV-negative U968 cells. We studied the expression of IFN-stimulated genes (ISGs) in two pairs of Burkitt's lymphoma cell lines, differing in the expression of the putative immortalizing gene of EBV, EBNA2. (Abstract truncated).enantigenebiological chemistryBurkitt's lymphomaDNA binding proteingene expressiongenetic transcriptioninterferonLymphomamolecular biologyMolecular geneticsregulationtranscription factorViral antigene615610620572The EBNA2-related resistance towards Alpha interferon -IFN-alpha- in Burkitt's lymphoma cells effects induction of IFN-induced genes but not the activation of transcription factor ISGF-3journal article