Schuhmann, B.B.SchuhmannDietrich, A.A.DietrichSel, S.S.SelHahn, C.C.HahnKlingenspor, M.M.KlingensporLommatzsch, M.M.LommatzschGudermann, T.T.GudermannBraun, A.A.BraunRenz, H.H.RenzNockher, W.A.W.A.Nockher2022-03-032022-03-032005https://publica.fraunhofer.de/handle/publica/20789910.1016/j.jneuroim.2005.01.023In the present study, we demonstrated a significant reduction of B lymphocytes in the blood, spleen and bone marrow of BDNF deficient mice. The observed developmental block in bone marrow B cell development was linked specifically to the Pre-BII stage. B lymphocytes express the BDNF receptors p75NTR and TrkBgp95, while no BDNF expression was found. However, a strong BDNF expression was demonstrated in bone marrow stromal cells. An increase of intracellular free calcium [Ca2+]i in B lymphocytes after BDNF application confirms a direct responsiveness of B lymphocytes to BDNF. In conclusion, these results suggest a role of BDNF for normal B lymphocyte development through paracrine effects in the bone marrow.enNeutrophinsbrain-derived neurotrophic factorHematopoesisbone marrow stromal cellneuroimmunology615610620616journal article