Walker, SimonaSimonaWalkerSchönfelder, JessyJessySchönfelderTugtekin, Sems-MalteSems-MalteTugtekinWetzel, ChristianeChristianeWetzelHacker, Michael C.Michael C.HackerSchulz-Siegmund, MichaelaMichaelaSchulz-Siegmund2022-03-052022-03-052018https://publica.fraunhofer.de/handle/publica/25567310.1089/ten.tec.2018.0285Pericardium-based tissue transplantation is a lifesaving treatment. Commercial glutaraldehyde-treated pericardial tissue exhibits cytotoxicity, which is associated with the accelerated graft failure. Replacement of glutaraldehyde has been suggested to overcome those drawbacks. In this study, we report a toxin-free method that combines tissue stabilization with a terminal sterilization. Our data indicate that the SULEEI procedure, which is part of an issued patent, may be a promising first step toward glutaraldehyde-free pericardium-based tissue transplants. Thus, our results may contribute to improving cardiovascular treatment strategies.ensterilizationpericardiumlow-energy electron irradiationionizing irradiationlow energyglutaraldehydeSULEEI620570667670journal article