Fahrig, R.R.Fahrig2022-03-032022-03-031993https://publica.fraunhofer.de/handle/publica/18293810.2307/3431735More than any other environmental chemicals, dioxins have been in the limelight of public interest for about 10 years. In addition to carcinogenicity, genetic risk is a cause for concern. Mutagenicity tests performed so far do not give a clear picture. The mutagenic potential of dioxins has to be considered weak or absent. Therefore, it seemed profitable to investigate comutagenicity and co-recombinogenicity of dioxins more thoroughly. The only useful method for investigating comutagenicity and co-recombinogenicity of dioxins in vivo is the spot test with mice. In this test system, a number of cocarcinogens and tumor promoters have shown comutagenic or co-recombinogenic effects. In the present study, tetrachlorodibenzo-p-dioxin (TCDD) and two environmental dioxin mixtures (pentachlorodibenzodioxin - PCDD - 1 and 2) were tested for genetic activity.enantimutagencarcinogenCarcinogenesiscarcinogenicity testingcocarcinogendioxingenetic recombinationgenetic toxicologygeneticsmousemutagenmutagenesismutagenicity testingpentachlorodibenzodioxinspot testtetrachlorodibenzodioxin615610620363journal article