Wolberg, M.M.WolbergDassen, B.H.N.B.H.N.DassenSchürmann, M.M.SchürmannJennewein, S.S.JenneweinWubbolts, M.G.M.G.WubboltsSchoemaker, H.E.H.E.SchoemakerMink, D.D.Mink2022-03-042022-03-042008https://publica.fraunhofer.de/handle/publica/21625110.1002/adsc.200800224A new large-scale approach to the synthetically versatile chloromethyl-substituted, alpha,beta-unsaturated delta-lactone 3 is described. The synthesis is based oil a blocatalytic process performed oil an industrial scale. Conjugate addition of G, N-, O-, and S-nucleophiles to lactone 3 affords a variety of new pyranoid building blocks in a highly diastereoselective manner. The operational simplicity of the whole sequence allows for preparing these building blocks oil an attractive scale.en540660journal article