Meyer, J.J.Meyer2022-03-082022-03-082007https://publica.fraunhofer.de/handle/publica/307759NOVELTY - The apparatus for the measurement of cells, by the patch clamp method, has a flat array of micro dishes (1) to hold the cells (2). A second number of micro pipettes (3) are positioned in relation to the dishes, to simultaneously investigate the cells. DETAILED DESCRIPTION - The layout of the micro dishes match the micro pipettes, in a small screen size in at least one direction. The dishes and pipettes can be offset to the side, in relation to each other, to give a repeated and simultaneous study of the cells. A micro motor positions and/or displaces the micro pipettes and micro dishes in relation to each other. The assembly has a cell feed and/or a flushing system to remove the cells. A filter (4) is at the rear side of the micro dish assembly. USE - The patch clamp method is for the measurement of bio-electric signals, from the electric potential within a cell, and an ion transport process by the ion channels as current through the cell membrane. It is used in neuro science s to research the effects of pharmaceuticals and chemotherapy on the activity of the ion channels. ADVANTAGE - The system, using the patch clamp method, allows the study of a number of cells simultaneously, in an automated operation, without microscopic control. The cells are within the smallest space possible for patch clamp measurements in the shortest times.de608610620patent1997-19744649