Api, A.M.A.M.ApiBelsito, D.D.BelsitoBotelho, D.D.BotelhoBrowne, D.D.BrowneBruze, M.M.BruzeBurton, G.A.G.A.BurtonBuschmann, J.J.BuschmannCalow, P.P.CalowDagli, M.L.M.L.DagliDate, M.M.DateDekant, W.W.DekantDeodhar, C.C.DeodharFryer, A.D.A.D.FryerJoshi, K.K.JoshiLa Cava, S.S.La CavaLapczynski, A.A.LapczynskiLiebler, D.C.D.C.LieblerO'Brien, D.D.O'BrienParakhia, R.R.ParakhiaPatel, A.A.PatelPenning, T.M.T.M.PenningRitacco, G.G.RitaccoRomine, J.J.RomineSalvito, D.D.SalvitoSchultz, T.W.T.W.SchultzSipes, I.G.I.G.SipesThakkar, Y.Y.ThakkarTsang, S.S.TsangWahler, J.J.Wahler2022-03-052022-03-052017https://publica.fraunhofer.de/handle/publica/24927910.1016/j.fct.2017.05.066The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog isoamyl acetate (CAS# 123-92-2) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 mg/kg/day and 1.4 mg/day, respectively). The repeated dose and developmental endpoint was completed using data on the target material, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.en615journal article