Api, A.M.A.M.ApiBelsito, D.D.BelsitoBotelho, D.D.BotelhoBrowne, D.D.BrowneBruze, M.M.BruzeBurton, G.A.G.A.BurtonBuschmann, JochenJochenBuschmannCalow, P.P.CalowDagli, M.L.M.L.DagliDate, M.M.DateDekant, W.W.DekantDeodhar, C.C.DeodharFryer, A.D.A.D.FryerJoshi, K.K.JoshiCava, S. laS. laCavaLapczynski, A.A.LapczynskiLiebler, D.C.D.C.LieblerO'Brien, D.D.O'BrienParakhia, R.R.ParakhiaPatel, A.A.PatelPenning, T.M.T.M.PenningRitacco, G.G.RitaccoRomine, J.J.RomineSalvito, D.D.SalvitoSchultz, T.W.T.W.SchultzSipes, I.G.I.G.SipesThakkar, Y.Y.ThakkarTsang, S.S.TsangWahler, J.J.Wahler2022-03-052022-03-052017https://publica.fraunhofer.de/handle/publica/25254310.1016/j.fct.2017.04.031The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analogue d-cyclocitronellene acetate (CAS # 25225-10-9) show that this material does not have skin sensitization potential. The repeated dose, reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03, 0.03 mg/kg/day and 1.4 mg/day, respectively). The developmental toxicity endpoint was completed using data from the target material which provided a MOE >100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.engenotoxicityrepeated dose toxicitydevelopmental and reproductive toxicityskin sensitization615journal article