CC BY 4.0Quiroga, Andrés F.Andrés F.QuirogaCortese, LorenzoLorenzoCorteseVerma, ManishManishVermaDannberg, PeterPeterDannbergTachtsidis, IliasIliasTachtsidisDanz, NorbertNorbertDanzDurdurán, TurgutTurgutDurdurán2025-10-082025-10-082025https://publica.fraunhofer.de/handle/publica/497153https://doi.org/10.24406/publica-566410.1364/BOE.57127610.24406/publica-56642-s2.0-105016687392In this paper, we introduce a speckle contrast optical spectroscopy/tomography (SCOS/SCOT) configuration based on an integrated imaging approach exploiting 113 micro-objectives mounted on a commercial CMOS camera that operates without fiber coupling, suitable for direct skin contact measurements and simultaneous multiple source-detector separation acquisitions. This compact system was validated ex vivo on phantoms and in vivo by monitoring the blood flow on the forearm muscle of a healthy human subject. The measurements, performed at multiple source-detector separations and camera exposure times, demonstrate excellent agreement with the theory based on the correlation-diffusion model. In vivo data demonstrate the capability of tracking pulsatile blood flow with a high signal-to-noise ratio (>4 harmonics of the cardiac pulse frequency detected) and sensitivity to small changes in muscle blood flow. This micro-objective array-based design overcomes a key challenge towards wearable SCOS/SCOT devices.enfalsejournal article