Grumann, M.M.GrumannDobmeier, M.M.DobmeierSchippers, P.P.SchippersBrenner, T.T.BrennerZengerle, R.R.ZengerleDucrée, J.J.DucréeKuhn, A.A.KuhnFritsche, M.M.Fritsche2022-03-032022-03-032004https://publica.fraunhofer.de/handle/publica/206853This publication presents the basic studies and the design optimization process of a microfluidic aggregation chamber in order to achieve highly periodical and mechanically stable monolayers of beads. All investigated designs of microfluidic devices exhibit one inlet channel connected to the so-called aggregation chamber. This chamber measures a depth which only slightly exceeds the diameter of the beads and possesses several outlet channels. With depths of the outlets smaller than a bead diameter, the beads are kept back and forced to accumulate inside the aggregation chamber as a monolayer. CFD-simulations are carried out to describe the process of filling and to assist the process of design optimization.enmonolayercomputational fluid dynamicsSchaltungMikrofluidik670book article