D'Oca, C.R.M.C.R.M.D'OcaNaciuk, F.F.F.F.NaciukSilva, J.C.J.C.SilvaGuedes, E.P.E.P.GuedesMoro, C.C.C.C.MoroD'Oca, M.G.M.M.G.M.D'OcaSantos, L.S.L.S.SantosNatchigall, F.M.F.M.NatchigallRussowsky, D.D.Russowsky2022-03-052022-03-052017https://publica.fraunhofer.de/handle/publica/25205810.5935/0103-5053.20160175A new approach based on multicomponent/domino combined reactions for the synthesis of gamma-nitroesters promoted by a mixed aluminium-magnesium oxides derived from hydrotalcite-like material was developed. Different gamma-nitroesters were synthesized in 15-95% yield using Meldrum's acid, aromatic aldehydes, nitromethane and different alcohols as reagents and solvents. The gamma-aminobutyric acid derivatives, Phenibut and Baclofen, were prepared in 63 and 61% overall yield, respectively, through a two steps synthetic strategy. A mechanistic pathway was proposed based on the gas chromatography mass spectrometry (GC-MS) and electrospray ionization mass spectrometry (ESI-MS) experiments.enjournal article