Koch, W.W.KochWindt, H.H.WindtWalles, M.M.WallesBorlak, J.J.BorlakClausing, P.P.Clausing2022-03-032022-03-032001https://publica.fraunhofer.de/handle/publica/19952910.1080/08958370150502476A method for inhalative exposure of minipigs to aerosols and gases has been developed. Minipigs are exposed via mask inhalation to the test substance using a computer-controlled exposure system that permits simultaneous exposure of groups of four animals in parallel to different controlled dose levels. We studied inhalation treatment of verapamil, a cardiovascular drug, and show good absorption and favorable pharmacokinetics when compared with in drug application. The results shown in this study encourage inhalation studies with the Göttingen minipig.eninhalation toxicologychemicaldruggasPharmacokineticmedicine experiment615610620journal article