Fuhr, G.R.G.R.FuhrZimmermann, H.H.Zimmermann2022-03-082022-03-082005https://publica.fraunhofer.de/handle/publica/306832Es wird ein Verfahren zur Bewegung einer Sonde (10) durch ein Zellmaterial (20) beschrieben, das aus biologischen Zellen (21) gebildet ist, wobei die Sonde (10) die Zellen (21) verletzungsfrei verdraengt. Es werden auch eine Sonde (10) zur Durchfuehrung des Verfahrens und ein Zellmanipulator, der mit mindestens einer derartigen Sonde ausgestattet ist, beschrieben.WO2004074425 A UPAB: 20050103 NOVELTY - For the formation of cell material (20) with a number of biological cells (21), in a defined geometric configuration, a robot (10) is prepared with a tool body (11) with surfaces (12) in contact with the cell material at least partially. The robot is adjusted to alter the geometric character of the tool surface and the geometric configuration of the cells. The robot tool has a hollow body (11) with a hollow interior (31), which is expanded and contracted using a pressure line (13) linked to a pressure supply (30), or an inserted body. The manipulator tool is advanced at a speed of 0.1 micro m/hour to 1 mm/hour, and preferably 1-500 micro m/hour. USE - The system is for setting or changing the surface topography of cell material, e.g. for tissue engineering. The cells can be, fibroblasts, macrophages, lymphocytes, tumor or nerve cells, and the like. The cell material is an accumulation of cells in adhesion contact with their environment through macro-molecular chemical bonds e.g. in tissue or an organ. ADVANTAGE - The cell material is formed by alteration of the shape, density, size and/or structure without injury to the separate cells.de608610620patent2003-10307487