Herz, MarionMarionHerzRank, AndreasAndreasRankTovar, Günter E.M.Günter E.M.TovarHirth, ThomasThomasHirthKaltenbacher, DominikDominikKaltenbacherStallkamp, JanJanStallkampWeber, AchimAchimWeber2022-03-112022-03-112009https://publica.fraunhofer.de/handle/publica/36405610.1557/PROC-1190-NN11-23Tumor resection done by minimally invasive procedure owns the challenge of a fast and reliable differentiation between healthy and tumorous tissue. We aim at investigating and developing a method for an intraoperative visualization of tumor cells with functionalized nanoparticles. The goal is to use this technique for the intraoperative use. Our so-called biohybrid systems consist of nanoparticies that are produced by Stober synthesis and coupled with bio active proteins. Such biomimetic nanostructures are capable of imitating the effects of membrane-bound cytokines, which bind to tumor cells for labeling them. A flexible and modular test environment has been developed to evaluate the spraying properties of the particles and to study tissue probes. It enables a fast investigation of different particle configurations and spraying parameters like pressure, spray volume, nozzle geometry, etc.enbiotechnologyGewebeLaboratory automationOperationtumor diagnosticTumordiagnostikNanopartikelBiotechnologieLaboratorium660530conference paper