Schiestel, ThomasThomasSchiestelRupp, S.S.RuppBrunner, H.H.Brunner2022-03-082022-03-082005https://publica.fraunhofer.de/handle/publica/306695Die Erfindung betrifft ein Verfahren zur Charakterisierung von Nanodomaenen aufweisenden Oberflaechen, wobei Biosensoren die an Nanopartikeln immobilisierten Affinitaetsmolekuele aufweisen, mit einer Nanodomaenen aufweisenden Oberflaeche inkubiert werden und die Bindung der Biosensoren an eine Nanodomaene der Oberflaeche mittels einer Detektionseinrichtung charakterisiert wird.EP 1574859 A UPAB: 20051024 NOVELTY - In a process to characterise a surface nano-domain, biosensors incorporating immobilised affinity molecules on nanoparticles are incubated on a surface incorporating nano-domains. The bond between biosensors and surface nano-domain is characterised by a detection assembly. DETAILED DESCRIPTION - In a process to characterise a surface nano-domain, biosensors incorporating immobilised affinity molecules on nanoparticles are incubated on a surface incorporating nano-domains. The bond between biosensors and surface nano-domain is characterised by a detection assembly. The affinity molecule is e.g. an oligonucleotide, polynucleotide, natural or synthetic antibody or fragment thereof, an aptamer, a lectin, a peptide, an oligopeptide, an amino acid derivative, a nucleotide, glycoprotein, a cofactor, a vitamin, an enzyme, a bacteria and/or a virus. USE - The process is used to characterise a surface nano-domain in a medical application e.g. dialysis membrane. ADVANTAGE - The method shows the relationship of the flat surface to a polymer-nanodomain, biosensor and gold nanoparticle.de608610620660patent102004013052