Steinmetz, N.F.N.F.SteinmetzMiertens, M.E.M.E.MiertensTaurog, R.E.R.E.TaurogJohnson, J.E.J.E.JohnsonCommandeur, U.U.CommandeurFischer, R.R.FischerManchester, M.M.Manchester2022-03-042022-03-042010https://publica.fraunhofer.de/handle/publica/22398410.1021/nl9035753We demonstrate that nanoparticles formed from the rod-shaped plant virus Potato virus X (PVX) can serve as a novel platform for biomedical applications. Bioconjugation protocols including amine modification and "click" chemistry allowed the efficient functionalization of PVX with biotins, dyes, and PEGs. Fluorescent-labeled and PEGylated PVX particles revealed that different fluorescent labels have a profound effect on PVX-cell interactions. Applying bioconjugation chemistries to PVX opens the door for chemical functionalization with targeting and therapeutic molecules.en540620journal article