Guder, J.C.J.C.GuderBuchhaupt, M.M.BuchhauptHuth, I.I.HuthHannappel, A.A.HannappelFerreirós, N.N.FerreirósGeisslinger, G.G.GeisslingerSchrader, J.J.Schrader2022-03-042022-03-042014https://publica.fraunhofer.de/handle/publica/23883810.1007/s10529-014-1610-6Prostaglandins (PGs) act as potent local hormones in nearly all tissues of the human body and are used for various medical applications. Heterologous expression of PG endoperoxide H-synthase from the alga, Gracilaria vermiculophylla, into E. coli and the application of this strain in biotransformation experiments resulted in a highly efficient conversion of arachidonic acid (ARA) yielding up to 130 mg natural PGs l−1 in a laboratory scale approach. Detailed analyses of the products and production kinetics were performed, confirming a rapid conversion of ARA to PGs.en540571572journal article