Filters

7 5
12
Reset filters

Settings
Author: Neumann, T. ×

Publications Search Results

Now showing 1 - 10 of 12
  • Publication
    Offshore wind farm cluster wakes as observed by long-range-scanning wind lidar measurements and mesoscale modeling
    ( 2022)
    Cañadillas, B.
    ;
    Beckenbauer, M.
    ;
    Trujillo, J.J.
    ;
    Dörenkämper, Martin
    ;
    Foreman, R.
    ;
    Neumann, T.
    ;
    Lampert, A.
    As part of the ongoing X-Wakes research project, a 5-month wake-measurement campaign was conducted using a scanning lidar installed amongst a cluster of offshore wind farms in the German Bight. The main objectives of this study are (1) to demonstrate the performance of such a system and thus quantify cluster wake effects reliably and (2) to obtain experimental data to validate the cluster wake effect simulated by the flow models involved in the project. Due to the lack of free wind flow for the wake flow directions, wind speeds obtained from a mesoscale model (without any wind farm parameterization) for the same time period were used as a reference to estimate the wind speed deficit caused by the wind farm wakes under different wind directions and atmospheric stabilities. For wind farm waked wind directions, the lidar data show that the wind speed is reduced up to 30ĝ€¯% at a wind speed of about 10 m s-1, depending on atmospheric stability and distance to the wind farm. For illustrating the spatial extent of cluster wakes, an airborne dataset obtained during the scanning wind lidar campaign is used and compared with the mesoscale model with wind farm parameterization and the scanning lidar. A comparison with the results of the model with a wind farm parameterization and the scanning lidar data reveals a relatively good agreement in neutral and unstable conditions (within about 2 % for the wind speed), whereas in stable conditions the largest discrepancies between the model and measurements are found. The comparative multi-sensor and model approach proves to be an efficient way to analyze the complex flow situation in a modern offshore wind cluster, where phenomena at different length scales and timescales need to be addressed.
  • Publication
    Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development
    ( 2020)
    Marx, U.
    ;
    Akabane, T.
    ;
    Andersson, T.B.
    ;
    Baker, E.
    ;
    Beilmann, M.
    ;
    Beken, S.
    ;
    Brendler-Schwaab, S.
    ;
    Cirit, M.
    ;
    David, R.
    ;
    Dehne, E.-M.
    ;
    Durieux, I.
    ;
    Ewart, L.
    ;
    Fitzpatrick, S.C.
    ;
    Frey, O.
    ;
    Fuchs, F.
    ;
    Griffith, L.G.
    ;
    Hamilton, G.A.
    ;
    Hartung, T.
    ;
    Hoeng, J.
    ;
    Hogberg, H.
    ;
    Hughes, D.J.
    ;
    Ingber, D.E.
    ;
    Iskandar, A.
    ;
    Kanamori, T.
    ;
    Kojima, H.
    ;
    Kuehnl, J.
    ;
    Leist, M.
    ;
    Li, B.
    ;
    Loskill, P.
    ;
    Mendrick, D.L.
    ;
    Neumann, T.
    ;
    Pallocca, G.
    ;
    Rusyn, I.
    ;
    Smirnova, L.
    ;
    Steger-Hartmann, T.
    ;
    Tagle, D.A.
    ;
    Tonevitsky, A.
    ;
    Tsyb, S.
    ;
    Trapecar, M.
    ;
    Water, B. van de
    ;
    Eijnden-van Raaij, J. van den
    ;
    Vulto, P.
    ;
    Watanabe, K.
    ;
    Wolf, A.
    ;
    Zhou, X.
    ;
    Roth, A.
    The first microfluidic microphysiological systems (MPS) entered the academic scene more than 15 years ago and were considered an enabling technology to human (patho)biology in vitro and, therefore, provide alternative approaches to laboratory animals in pharmaceutical drug development and academic research. Nowadays, the field generates more than a thousand scientific publications per year. Despite the MPS hype in academia and by platform providers, which says this technology is about to reshape the entire in vitro culture landscape in basic and applied research, MPS approaches have neither been widely adopted by the pharmaceutical industry yet nor reached regulated drug authorization processes at all. Here, 46 leading experts from all stakeholders - academia, MPS supplier industry, pharmaceutical and consumer products industries, and leading regulatory agencies - worldwide have analyzed existing challenges and hurdles along the MPS-based assay life cycle in a second workshop of this kind in June 2019. They identified that the level of qualification of MPS-based assays for a given context of use and a communication gap between stakeholders are the major challenges for industrial adoption by end-users. Finally, a regulatory acceptance dilemma exists against that background. This t4 report elaborates on these findings in detail and summarizes solutions how to overcome the roadblocks. It provides recommendations and a roadmap towards regulatory accepted MPS-based models and assays for patients' benefit and further laboratory animal reduction in drug development. Finally, experts highlighted the potential of MPS-based human disease models to feedback into laboratory animal replacement in basic life science research.
  • Publication
    Standardized assessment of meteorological data from FINO platforms
    ( 2016)
    Bastigkeit, I.
    ;
    Bégué, F.
    ;
    Frühmann, R.
    ;
    Gates, L.
    ;
    Herklotz, K.
    ;
    Leiding, T.
    ;
    Müller, S.
    ;
    Neumann, T.
    ;
    Schwenk, P.
    ;
    Sedlatschek, R.
    ;
    Senet, C.
    ;
    Tinz, B.
    ;
    Wilts, F.
    In order to investigate conditions for offshore wind power generation in the German coastal areas, three research platforms were constructed in the North Sea (FINO1 and FINO3) and in the Baltic Sea (FINO2). Measurement masts at each platform are equipped with a range of meteorological sensors at heights of 30 to 100 m above sea level. To improve the comparison of the results of the different platforms standardized analysis and interpretation of the data is necessary. This is one of the major topics of the joint project FINO-Wind. The project will establish a consistent archive standardized wind data of the platforms adjusted for local effects.
  • Publication
    Standardization of meteorological data from offshore platforms
    ( 2015)
    Neumann, T.
    ;
    Bégué, F.
    ;
    Wilts, F.
    ;
    Leiding, T.
    ;
    Tinz, B.
    ;
    Gates, L.
    ;
    Senet, C.
    ;
    Schwenk, P.
    ;
    Bastigkeit, I.
    ;
    Müller, S.
  • Publication
    Standardization of meteorological data from FINO offshore platforms
    ( 2015)
    Leiding, T.
    ;
    Bastigkeit, I.
    ;
    Bégué, F.
    ;
    Gates, L.
    ;
    Herklotz, K.
    ;
    Müller, S.
    ;
    Neumann, T.
    ;
    Schwenk, P.
    ;
    Senet, C.
    ;
    Tinz, B.
    ;
    Wilts, F.
  • Publication
    Standardization of marine meteorological data from FINO offshore platforms
    ( 2015)
    Leiding, T.
    ;
    Bastigkeit, I.
    ;
    Bégué, F.
    ;
    Gates, L.
    ;
    Herklotz, K.
    ;
    Müller, S.
    ;
    Neumann, T.
    ;
    Schwenk, P.
    ;
    Sedlatschek, R.
    ;
    Senet, C.
    ;
    Tinz, B.
    ;
    Wilts, F.
  • Publication
    Standardized assessment of meteorological data from Fino platforms
    ( 2015)
    Bégué, F.
    ;
    Bastigkeit, I.
    ;
    Leiding, T.
    ;
    Müller, S.
    ;
    Neumann, T.
    ;
    Schwenk, P.
    ;
    Tinz, B.
  • Publication
    Meteorological and oceanographic conditions at the FINO platforms during the severe storms Christian and Xaver
    ( 2014)
    Leiding, T.
    ;
    Tinz, B.
    ;
    Rosenhagen, G.
    ;
    Lefebvre, C.
    ;
    Haeseler, S.
    ;
    Hagemann, S.
    ;
    Bastigkeit, I.
    ;
    Stein, D.
    ;
    Schwenk, P.
    ;
    Müller, S.
    ;
    Outzen, O.
    ;
    Herklotz, K.
    ;
    Kinder, F.
    ;
    Neumann, T.
  • Publication
    Innovative Konzepte zur Druckentlastung mit integriertem Flammenschutz an Werkzeugmaschinen
    ( 2012)
    Bold, J.
    ;
    Duchstein, B.
    ;
    Mewis, J.
    ;
    Ziefle, A.
    ;
    Karrasch, I.
    ;
    Neumann, T.