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Author: Liu, Sijin ×

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Now showing 1 - 2 of 2
  • Publication
    Quantitative Comparison of Gold Nanoparticle Delivery via the Enhanced Permeation and Retention (EPR) Effect and Mesenchymal Stem Cell (MSC)-Based Targeting
    ( 2023)
    Xu, Lining
    ;
    Xu, Ming
    ;
    Sun, Xing
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    Feliu Torres, Neus
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    Feng, Liuxing
    ;
    Parak, Wolfgang J.
    ;
    Liu, Sijin
    There are still some gaps in existing knowledge in the field of cancer nanotheranostics, e.g., the efficiency of nanoparticle-loaded cells for targeted delivery. In the current study, gold nanoparticles (Au NPs) were delivered to tumors in both subcutaneous tumor and lung metastasis tumor models by intravenous injection of either free Au NPs or of human bone marrow mesenchymal stem cells (MSCs), which were loaded with endocytosed Au NPs. By making injections with the same dose of administrated Au NPs, it was possible to directly compare tumor targeting of both delivery modes. Hereby, the passive targeting of tumor by the plain Au NPs was facilitated by the enhanced permeation and retention (EPR) effect. Au NP retention by tumors, as well as tumor penetration, were found to be improved up to 2.4-to-9.3-fold when comparing the MSC-mediated delivery of Au NPs to the delivery of the plain Au NPs via EPR effect on day 7 post administration. While the absolute retention of Au NPs in the tumor remained low, our data show that, upon injection of the same amount of Au NPs, in fact MSC-mediated delivery is quantitatively higher than EPR-mediated delivery of NPs by half an order of magnitude.
  • Publication
    X-ray-Based Techniques to Study the Nano-Bio Interface
    ( 2021)
    Sanchez-Cano, Carlos
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    Alvarez-Puebla, Ramon A.
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    Abendroth, John M.
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    Beck, Tobias
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    Blick, Robert
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    Cao, Yuan
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    Caruso, Frank
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    Chakraborty, Indranath
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    Chapman, Henry N.
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    Chen, Chunying
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    Cohen, Bruce E.
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    Conceição, Andrew L.C.
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    Cormode, David P.
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    Cui, Daxiang
    ;
    Dawson, Kenneth A.
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    Falkenberg, Gerald
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    Fan, Chunhai
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    Feliu, Neus
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    Gao, Mingyuan
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    Gargioni, Elisabetta
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    Glüer, Claus-C.
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    Grüner, Florian
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    Hassan, Moustapha
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    Hu, Yong
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    Huang, Yalan
    ;
    Huber, Samuel
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    Huse, Nils
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    Kang, Yanan
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    Khademhosseini, Ali
    ;
    Keller, Thomas F.
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    Körnig, Christian
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    Kotov, Nicholas A.
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    Koziej, Dorota
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    Liang, Xing-Jie
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    Liu, Beibei
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    Liu, Sijin
    ;
    Liu, Yang
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    Liu, Ziyao
    ;
    Liz-Marzan, Luis M.
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    Ma, Xiaowei
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    Machicote, A.
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    Maison, W.
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    Mancuso, A.P.
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    Megahed, S.
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    Nickel, B.
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    Otto, F.
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    Palencia, C.
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    Pascarelli, S.
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    Pearson, A.
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    Penate-Medina, O.
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    Qi, B.
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    Rädler, J.
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    Richardson, J.J.
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    Rosenhahn, A.
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    Rothkamm, K.
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    Rübhausen, M.
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    Sanyal, M.K.
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    Schaak, R.E.
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    Schlemmer, H.-P.
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    Schmidt, M.
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    Schmutzler, O.
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    Schotten, Theo
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    Schulz, F.
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    Sood, A.K.
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    Spiers, K.M.
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    Staufer, T.
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    Stemer, D.M.
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    Stierle, A.
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    Sun, X.
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    Tsakanova, G.
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    Weiss, P.S.
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    Weller, H.
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    Westermeier, F.
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    Xu, M.
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    Yan, H.
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    Zeng, Y.
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    Zhao, Y.
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    Zhao, Y.
    ;
    Zhu, D.
    ;
    Zhu, Y.
    ;
    Parak, W.J.
    X-ray-based analytics are routinely applied in many fields, including physics, chemistry, materials science, and engineering. The full potential of such techniques in the life sciences and medicine, however, has not yet been fully exploited. We highlight current and upcoming advances in this direction. We describe different X-ray-based methodologies (including those performed at synchrotron light sources and X-ray free-electron lasers) and their potentials for application to investigate the nano-bio interface. The discussion is predominantly guided by asking how such methods could better help to understand and to improve nanoparticle-based drug delivery, though the concepts also apply to nano-bio interactions in general. We discuss current limitations and how they might be overcome, particularly for future use in vivo.