• English
  • Deutsch
  • Log In
    or
  • Research Outputs
  • Projects
  • Researchers
  • Institutes
  • Statistics
Repository logo
Fraunhofer-Gesellschaft
  1. Home
  2. Fraunhofer-Gesellschaft
  3. Artikel
  4. Detection of volatile metabolites derived from garlic (Allium sativum) in human urine
 
  • Details
  • Full
Options
2016
  • Zeitschriftenaufsatz

Titel

Detection of volatile metabolites derived from garlic (Allium sativum) in human urine

Abstract
The metabolism and excretion of flavor constituents of garlic, a common plant used in flavoring foods and attributed with several health benefits, in humans is not fully understood. Likewise, the physiologically active principles of garlic have not been fully clarified to date. It is possible that not only the parent compounds present in garlic but also its metabolites are responsible for the specific physiological properties of garlic, including its influence on the characteristic body odor signature of humans after garlic consumption. Accordingly, the aim of this study was to investigate potential garlic-derived metabolites in human urine. To this aim, 14 sets of urine samples were obtained from 12 volunteers, whereby each set comprised one sample that was collected prior to consumption of food-relevant concentrations of garlic, followed by five to eight subsequent samples after garlic consumption that covered a time interval of up to 26 h. The samples were analyzed chemo-analytically using gas chromatography-mass spectrometry/olfactometry (GC-MS/O), as well as sensorially by a trained human panel. The analyses revealed three different garlic-derived metabolites in urine, namely allyl methyl sulfide (AMS), allyl methyl sulfoxide (AMSO) and allyl methyl sulfone (AMSO2), confirming our previous findings on human milk metabolite composition. The excretion rates of these metabolites into urine were strongly time-dependent with distinct inter-individual differences. These findings indicate that the volatile odorant fraction of garlic is heavily biotransformed in humans, opening up a window into substance circulation within the human body with potential wider ramifications in view of physiological effects of this aromatic plant that is appreciated by humans in their daily diet.
Author(s)
Scheffler, Laura
Sauermann, Yvonne
Heinlein, Anja
Sharapa, Constanze
Buettner, Andrea
Fraunhofer-Institut für Verfahrenstechnik und Verpackung IVV
Zeitschrift
Metabolites
Thumbnail Image
DOI
10.3390/metabo6040043
Externer Link
Externer Link
Language
Englisch
google-scholar
IVV
  • Cookie settings
  • Imprint
  • Privacy policy
  • Api
  • Send Feedback
© 2022