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Yonsei Fraunhofer IZFP Medical Device Lab YFMED
Effect of nodakenin on atopic dermatitis-like skin lesions
Fraunhofer-Gesellschaft
2014
,
Park, S.-J.
,
Cha, H.-S.
,
Lee, Y.-H.
,
Kim, W.-J.
,
Kim, D.-H.
,
Kim, E.-C.
,
Lee, K.-H.
,
Kim, T.-J.
Nodakenin, derived from the roots of Angelica gigas Nakai, is an important natural resource and medicinal material with anti-allergic and anti-inflammatory activities. We have previously shown that nodakenin inhibits IgE/Ag-induced degranulation in mast cells. In this study, we investigated the inhibitory effect of nodakenin on 2,4-dinitrochloro-benzene (DNCB)-induced atopic dermatitis (AD)-like skin lesions in ICR mice. Scratching behavior, skin severity score, blood IgE level, and skin thickness were improved in DNCB-induced AD-like ICR mice. Our results showed that nodakenin suppressed the increase of AD-like skin lesions in ICR mice. These results suggest that nodakenin may be a potential therapeutic resource for AD as well as an adjunctive agent to control itching associated with AD.