Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.

Surfactant protein A in bronchoalveolar lavage of sarcoidosis and hypersensitivity pneumonitis


American Review of Respiratory Diseases 145 (1992), Nr.4.2, S.A877
ISSN: 0003-0805
American Lung Association (International Conference) <1992, Miami Beach/Fla.>
Fraunhofer ITA ( ITEM) ()
allergy; disorder; immunity; immunochemistry; lung; lymphoproliferative; macrophage; pneumonia; protein; pulmonary; sarcoidosis; surface active agent; surfactant

Our results suggest that sarcoidosis and hypersensitivity pneumonitis (HP) may induce increased Surfactant protein A (SP-A) secretion from alveolar type II cells. In HP, this response could support antigen elimination from the alveoli by enhancement of macrophage functions. In both diseases increased SP-A levels in bronchoalveolar lavage (BAL) may be indicative of increased total surfactant secretion. This would be beneficial in suppressing further lymphocyte activation which is a known immunomodulatory function of surfactant phospholipids.