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Pathologic effects of inhaled particles in rat lungs - Associations between inflammatory and neoplastic processes


Mohr, U.; Dungworth, D.L.; Mauderly, J.L.; Oberdörster, G. ; Medizinische Hochschule Hannover; International Life Sciences Institute -ILSI-, Washington/D.C.; Fraunhofer-Institut für Toxikologie und Aerosolforschung -ITA-, Hannover:
Toxic and carcinogenic effects of solid particles in the respiratory tract
Washington, DC: ILSI Press, 1994 (ILSI Monographs)
ISBN: 0-944398-14-6
Toxic and Carcinogenic Effects of Solid Particles in the Respiratory Tract <1993, Hannover>
International Symposium on Inhalation Toxicology <4, 1993, Hannover>
International Inhalation Symposium <4, 1993, Hannover>
Fraunhofer ITA ( ITEM) ()
aerosol; benzo(a)pyrene; cancer; carbon-black; carcinogen; Carcinogenesis; diesel motor exhaust gas; diesel soot; experimental; hyperplasia; inhalation toxicology; lung; metaplasia; particles; polycyclic aromatic hydrocarbon; rat; respiratory organ; titanium dioxide; toxicology; tumor

Ultrafine carbon black, diesel exhaust soot, and titanium dioxide are carcinogenic at sufficient exposure levels in rat lungs. A 30-month study is required to test properly the carcinogenicity of these and other particulates in rat inhalation studies. Carcinogenicity of the three particulate materials reviewed was shown by development of both bronchio-alveolar and squameous cell tumors. Tar/pitch condensation aerosol containing 50 ug/m3 BaP and other polycyclic hydrocarbons was shown to be carcinogenic only on the basis of development of squamous cell tumors. Particle induced tumors arose out of a background of hyperplasia and metaplasia associated with persistent inflammation in the rat lung. The association between inflammaton-related and neoplastic events indicates a high probability of a threshold effect for particle-induced carcinogenesis in the rat lung.