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Rapid development of micro-physiological systems using novel modular plug&play construction kit

Poster presented at Annual EUROoCS Conference 2020, 8.-9.7.2020, online (previously scheduled Uppsala)
: Behrens, Stephan; Schmieder, Florian; Günther, Katja; Sonntag, Frank

Poster urn:nbn:de:0011-n-5959116 (809 KByte PDF)
MD5 Fingerprint: 0fcc4de6d8b09ff7b1395d2809dcd74c
Created on: 17.7.2020

2020, 1 pp.
European Organ-on-Chip Society (EUROoCS Conference) <2020, Online>
European Commission EC
100325949; HERMES
Highspeed Erfassung und Regelung Mikrophysiologischer Eigenschaften mit einer intelligenten Steuerung
European Commission EC
100367055; TrioMed
Translation innovativer zellulärer Biophysik in die personalisierte Medizin
Poster, Electronic Publication
Fraunhofer IWS ()
micro physiological systems; MPS; Organ-on-a-chip; Multi-organ chip; Microfluidic; construction kit; cell culture

Micro-physiological platforms (MPS) - often referred as organ-on-chip or multi-organ-chip - have an enormous potential to strengthen research in drug development, toxicological screening, personalized medicine and disease modeling. The design of such MPS is an interdisciplinary challenge. At the beginning of development, many parameters and boundary conditions (geometries, volumes, flow rates, interfaces, and coatings) are often still unknown. The probability that the first draft will work is therefore very low. A large number of design cycles are necessary to develop a miniaturized MPS with a high functional density. However, we designed a modular plug&play construction kit for the development of MPS. The modular system provides a large number of functional, miniaturized modules such as pumps, oxygenators, reservoirs, sensors and cell culture compartments whose fluidic interfaces comply with the Luer-Lock standard. This allows a quick and easy combination of modules with each other, according to the intended application. By using the modular plug&play construction kit, the successful creation of different MPS setups has achieved in the shortest time and with minimal effort. A quick and easy integration of microfluidic components, pumps and sensors from third party suppliers is possible. Thus, with the help of the modular plug&play construction kit, a drastically reduction of financial and time expenditure of an MPS development is possible. Once an application-specific design has been successfully determined, it is possible to derive a compact MPS by following certain design rules.