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Immune cell-supplemented human skin model for studying fungal infections

: Kühbacher, Andreas; Sohn, Kai; Burger-Kentischer, Anke; Rupp, Steffen


Lion, T.:
Human fungal pathogen identification. Methods and protocols
New York/NY: Humana Press, 2017 (Methods in molecular biology 1508)
ISBN: 978-1-4939-6513-7 (Print)
ISBN: 978-1-4939-6515-1 (Online)
ISBN: 1-4939-6513-1
Book Article
Fraunhofer IGB ()
3D skin model; immune reaction to fungi; host–fungi interaction; infection model

Human skin is a niche for various fungal species which either colonize the surface of this tissue as commensals or, primarily under conditions of immunosuppression, invade the skin and cause infection. Here we present a method for generation of a human in vitro skin model supplemented with immune cells of choice. This model represents a complex yet amenable tool to study molecular mechanisms of host–fungi interactions at human skin.