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Role of different replacement fluids during extracorporeal treatment in a pig model of sepsis

: Sauer, Martin; Altrichter, Jens; Mencke, Thomas; Klöhr, Sven; Thomsen, Maren; Kreutzer, Hans J.; Nöldge-Schomburg, Gabriele; Mitzner, Steffen


Therapeutic apheresis and dialysis 17 (2013), No.1, pp.84-92
ISSN: 1091-6660
ISSN: 1744-9979
ISSN: 1744-9987
ISSN: 1526-0968
Journal Article
Fraunhofer IZI ()
centrifugation; colloids; extracorporeal therapy; plasma; septic shock

In an extracorporeal combination therapy, the impact of different replacement fluids on survival was tested in a bacterial sepsis model in pigs. In an animal study 19 pigs, weighing 7.5–11.1 kg, were included. All groups received an intravenous lethal dose of live Staphylococcus aureus over 1 h. The animals were treated by an extracorporeal circuit consisting of online centrifugation and subsequent plasma filtration for 4 h. The extracorporeal circuit was pre-filled with 400 mL replacement fluid. In the P0 group 100% hydroxyethyl starch 130/0.4 was used as replacement fluid; in the P30 group 30% pig plasma and 70% hydroxyethyl starch; and in the P100 group 100% pig plasma. The observation time was 7 days. All animals of the group P100 survived, while all animals of group P0 and five out of seven animals of the P30 group died during the observation time. Extracorporeal therapy consisting of online centrifugation and plasma filtration with 100% pig plasma as replacement fluid significantly improved survival in a pig model of sepsis. Further studies with this approach are encouraged.