Fraunhofer-Gesellschaft

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Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
202137/w mit unklarer einseitiger Kniegelenksschwellung
Köhm, M.
Zeitschriftenaufsatz
2021Activation of thyroid hormone receptor-β improved disease activity and metabolism independent of body weight in a mouse model of non-alcoholic steatohepatitis and fibrosis
Kannt, A.; Wohlfart, P.; Madsen, A.N.; Veidal, S.S.; Feigh, M.; Schmoll, D.
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2021AGMO Inhibitor Reduces 3T3-L1 Adipogenesis
Fischer, C.; Wilken-Schmitz, A.; Hernandez-Olmos, V.; Proschak, E.; Stark, H.; Fleming, I.; Weigert, A.; Thurn, M.; Hofmann, M.; Werner, E.R.; Geisslinger, G.; Niederberger, E.; Watschinger, K.; Tegeder, I.
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2021AKT1 and PTEN show the highest affinities among phosphoinositide binding proteins for the second messengers PtdIns(3,4,5)P3 and PtdIns(3,4)P2
Nelson, N.; Razeto, A.; Gilardi, A.; Grättinger, M.; Kirchmair, J.; Jücker, M.
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2021Aufgabenteilung im hausärztlichen Praxisteam bei der Durchführung von Versorgungsstudien
Mergenthal, K.; Schulz-Rothe, S.; Siebenhofer, A.; Gerlach, F.M.; Dauth, S.; Petersen, J.J.
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2021Autoimmune Chronic Spontaneous Urticaria Detection with IgG Anti-TPO and Total IgE
Kolkhir, P.; Kovalkova, E.; Chernov, A.; Danilycheva, I.; Krause, K.; Sauer, M.; Shulzhenko, A.; Fomina, D.; Maurer, M.
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2021Best Practices in the Development and Validation of Physiologically Based Biopharmaceutics Modeling. A Workshop Summary Report
Parrott, N.; Suarez-Sharp, S.; Kesisoglou, F.; Pathak, S.M.; Good, D.; Wagner, C.; Dallmann, A.; Mullin, J.; Patel, N.; Riedmaier, A.E.; Mitra, A.; Raines, K.; Butler, J.; Kakhi, M.; Li, M.; Zhao, Y.; Tsakalozou, E.; Flanagan, T.; Dressman, J.; Pepin, X.
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2021Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Carbamazepine
Garci­a, M.A.; Cristofoletti, R.; Abrahamsson, B.; Groot, D.W.; Parr, A.; Polli, J.E.; Mehta, M.; Shah, V.P.; Tomakazu, T.; Dressman, J.B.; Langguth, P.
Review
2021A Blueprint for High Affinity SARS-CoV-2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics
Gossen, J.; Albani, S.; Hanke, A.; Joseph, B.P.; Bergh, C.; Kuzikov, M.; Costanzi, E.; Manelfi, C.; Storici, P.; Gribbon, P.; Beccari, A.R.; Talarico, C.; Spyrakis, F.; Lindahl, E.; Zaliani, A.; Carloni, P.; Wade, R.C.; Musiani, F.; Kokh, D.B.; Rossetti, G.
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2021Chalcone-Supported Cardiac Mesoderm Induction in Human Pluripotent Stem Cells for Heart Muscle Engineering
Raad, F.S.; Khan, T.A.; Esser, T.U.; Hudson, J.E.; Seth, B.I.; Fujita, B.; Gandamala, R.; Tietze, L.F.; Zimmermann, W.H.
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2021Characterization of ACE Inhibitors and AT1R Antagonists with Regard to Their Effect on ACE2 Expression and Infection with SARS-CoV-2 Using a Caco-2 Cell Model
Reus, P.; Schneider, A.-K.; Ulshöfer, T.; Henke, M.; Bojkova, D.; Cinatl, J.; Ciesek, S.; Geisslinger, G.; Laux, V.; Grättinger, M.; Gribbon, P.; Schiffmann, S.
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2021Combined Cardioprotective and Adipocyte Browning Effects Promoted by the Eutomer of Dual sEH/PPARγ Modulator
Hartmann, M.; Bibli, S.-I.; Tews, D.; Ni, X.; Kircher, T.; Kramer, J.S.; Kilu, W.; Heering, J.; Hernandez-Olmos, V.; Weizel, L.; Scriba, G.K.E.; Krait, S.; Knapp, S.; Chaikuad, A.; Merk, D.; Fleming, I.; Fischer-Posovszky, P.; Proschak, E.
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2021Computational Functional Genomics-Based AmpliSeq™ Panel for Next-Generation Sequencing of Key Genes of Pain
Kringel, D.; Malkusch, S.; Kalso, E.; Lötsch, J.
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2021Cyp2c44 epoxygenase-derived epoxyeicosatrienoic acids in vascular smooth muscle cells elicit vasoconstriction of the murine ophthalmic artery
Hu, J.; Sisignano, M.; Brecht, R.; Perumal, N.; Angioni, C.; Bibli, I.-S.; Fisslthaler, B.; Kleinert, H.; Pfeiffer, N.; Fleming, I.; Manicam, C.
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2021Data Science-Based Analysis of Patient Subgroup Structures Suggest Effects of Rhinitis on All Chemosensory Perceptions in the Upper Airways
Lötsch, J.; Hummel, T.
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2021Data-science based analysis of perceptual spaces of odors in olfactory loss
Lötsch, J.; Ultsch, A.; Hähner, A.; Willgeroth, V.; Bensafi, M.; Zaliani, A.; Hummel, T.
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2021Demonstrating Ligandability of the LC3A and LC3B Adapter Interface
Hartmann, M.; Huber, J.; Kramer, J.S.; Heering, J.; Pietsch, L.; Stark, H.; Odadzic, D.; Bischoff, I.; Fürst, R.; Schröder, M.; Akutsu, M.; Chaikuad, A.; Dötsch, V.; Knapp, S.; Biondi, R.M.; Rogov, V.V.; Proschak, E.
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2021Design, Synthesis and Antiparasitic Evaluation of Click Phospholipids
Magoulas, G.E.; Afroudakis, P.; Georgikopoulou, K.; Roussaki, M.; Borsari, C.; Fotopoulou, T.; Santarem, N.; Barrias, E.; Tejera Nevado, P.; Hachenberg, J.; Bifeld, E.; Ellinger, B.; Kuzikov, M.; Fragiadaki, I.; Scoulica, E.; Clos, J.; Gul, S.; Costi, M.P.; Souza, W. de; Prousis, K.C.; Silva, A.C. da; Calogeropoulou, T.
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2021Discovery of Irbesartan Derivatives as BLT2 Agonists by Virtual Screening
Hernandez-Olmos, V.; Heering, J.; Bischoff-Kont, I.; Kaps, A.; Rajkumar, R.; Liu, T.; Fürst, R.; Steinhilber, D.; Proschak, E.
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2021Droplet-based vitrification of adherent human induced pluripotent stem cells on alginate microcarrier influenced by adhesion time and matrix elasticity
Meiser, Ina; Majer, Julia; Katsen-Globa, Alisa; Schulz, André; Schmidt, Katharina; Stracke, Frank; Koutsouraki, Eirini; Witt, Gesa; Keminer, Oliver; Pless, Ole; Gardner, John; Claussen, Carsten; Gribbon, Philip; Neubauer, Julia; Zimmermann, Heiko
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2021Drugs and Epigenetic Molecular Functions. A Pharmacological Data Scientometric Analysis
Kringel, D.; Malkusch, S.; Lötsch, J.
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2021Effect of Mastiha supplementation on NAFLD: The MAST4HEALTH Randomised, Controlled Trial
Amerikanou, C.; Kanoni, S.; Kaliora, A.C.; Barone, A.; Bjelan, M.; D'Auria, G.; Gioxari, A.; Gosalbes, M.J.; Mouchti, S.; Stathopoulou, M.G.; Soriano, B.; Stojanoski, S.; Banerjee, R.; Halabalaki, M.; Mikropoulou, E.V.; Kannt, A.; Lamont, J.; Llorens, C.; Marascio, F.; Marascio, M.; Roig, F.J.; Smyrnioudis, I.; Varlamis, I.; Visvikis-Siest, S.; Vukic, M.; Milic, N.; Medic-Stojanoska, M.; Cesarini, L.; Campolo, J.; Gastaldelli, A.; Deloukas, P.; Trivella, M.G.; Francino, M.P.; Dedoussis, G.V.
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2021Effects of Alzheimer-Like Pathology on Homocysteine and Homocysteic Acid Levels - An Exploratory In Vivo Kinetic Study
Nieraad, H.; Bruin, N. de; Arne, O.; Hofmann, M.C.J.; Gurke, R.; Schmidt, D.; Ritter, M.; Parnham, M.J.; Geisslinger, G.
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2021Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5) Deficiency on Systemic Insulin Sensitivity and Adipose Tissue
Dommel, S.; Hoffmann, A.; Berger, C.; Kern, M.; Klöting, N.; Kannt, A.; Blüher, M.
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2021Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions
Willems, S.; Gellrich, L.; Chaikuad, A.; Kluge, S.; Werz, O.; Heering, J.; Knapp, S.; Lorkowski, S.; Schubert-Zsilavecz, M.; Merk, D.
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2021Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis
Rosenkranz, S.C.; Shaposhnykov, A.A.; Träger, S.; Engler, J.B.; Witte, M.E.; Roth, V.; Vieira, V.; Paauw, N.; Bauer, S.; Schwencke-Westphal, C.; Schubert, C.; Bal, L.C.; Schattling, B.; Pless, O.; Horssen, J. van; Freichel, M.; Friese, M.A.
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2021Establishment of a second generation homozygous CRISPRa human induced pluripotent stem cell (hiPSC) line for enhanced levels of endogenous gene activation
Schoger, E.; Zimmermann, W.-H.; Cyganek, L.; Zelarayán, L.C.
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2021Establishment of two homozygous CRISPR interference (CRISPRi) knock-in human induced pluripotent stem cell (hiPSC) lines for titratable endogenous gene repression
Schoger, E.; Zimmermann, W.-H.; Cyganek, L.; Zelarayán, L.C.
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2021Evaluating the impact of acid-reducing agents on drug absorption using biorelevant in vitro tools and PBPK modeling - case example dipyridamole
Segregur, D.; Barker, R.; Mann, J.; Moir, A.; Karlsson, E.M.; Turner, D.B.; Arora, S.; Dressman, J.
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2021Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation
Kannt, A.; Dikic, I.
Review
2021Exploring the Role of ATP-Citrate Lyase in the Immune System
Dominguez, M.; Brüne, B.; Namgaladze, D.
Review
2021Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
Santos, G.L.; Meyer, T.; Tiburcy, M.; Degrave, A.; Zimmermann, W.-H.; Lutz, S.
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2021Fragment-like Chloroquinolineamines Activate the Orphan Nuclear Receptor Nurr1 and Elucidate Activation Mechanisms
Willems, S.; Ohrndorf, J.; Kilu, W.; Heering, J.; Merk, D.
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2021Gap junction-mediated cell-cell interaction between transplanted mesenchymal stem cells and vascular endothelium in stroke
Kikuchi-Taura, A.; Okinaka, Y.; Saino, O.; Takeuchi, Y.; Ogawa, Y.; Kimura, T.; Gul, S.; Claussen, C.; Boltze, J.; Taguchi, A.
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2021Genome and Secretome Analysis of Staphylotrichum longicolleum DSM105789 Cultured on Agro-Residual and Chitinous Biomass
Ali, A.; Ellinger, B.; Brandt, S.C.; Betzel, C.; Rühl, M.; Wrenger, C.; Schlüter, H.; Schäfer, W.; Brognaro, H.; Gand, M.
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2021Hantavirus Replication Cycle - An Updated Structural Virology Perspective
Meier, K.; Thorkelsson, S.R.; Quemin, E.R.J.; Rosenthal, M.
Review
2021Heterodimer formation with retinoic acid receptor RXRα modulates coactivator recruitment by peroxisome proliferator-activated receptor PPARγ
Kilu, W.; Merk, D.; Steinhilber, D.; Proschak, E.; Heering, J.
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2021High-Throughput Screening for CEBPD-Modulating Compounds in THP-1-Derived Reporter Macrophages Identifies Anti-Inflammatory HDAC and BET Inhibitors
Ullmann, T.; Luckhardt, S.; Wolf, M.; Parnham, M.J.; Resch, E.
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2021Highlights from the 2020 AAPS 360 Annual Meeting
Gray, V.A.; Diaz, D.A.; Dressman, J.; Tsume, Y.; Fotaki, N.
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2021Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen
Kuzikov, M.; Costanzi, E.; Reinshagen, J.; Esposito, F.; Vangeel, L.; Wolf, M.; Ellinger, B.; Claussen, C.; Geisslinger, G.; Corona, A.; Iaconis, D.; Talarico, C.; Manelfi, C.; Cannalire, R.; Rossetti, G.; Gossen, J.; Albani, S.; Musiani, F.; Herzog, K.; Ye, Y.; Giabbai, B.; Demitri, N.; Jochmans, D.; Jonghe, S.D.; Rymenants, J.; Summa, V.; Tramontano, E.; Beccari, A.R.; Leyssen, P.; Storici, P.; Neyts, J.; Gribbon, P.; Zaliani, A.
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2021IL-38 Ablation Reduces Local Inflammation and Disease Severity in Experimental Autoimmune Encephalomyelitis
Huard, A.; Do, H.N.; Frank, A.-C.; Sirait-Fischer, E.; Fuhrmann, D.; Hofmann, M.C.J.; Raue, R.; Palmer, G.; Brüne, B.; Bruin, N. de; Weigert, A.
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2021The immune suppressive microenvironment affects efficacy of radio-immunotherapy in brain metastasis
Niesel, K.; Schulz, M.; Anthes, J.; Alekseeva, T.; Macas, J.; Salamero-Boix, A.; Möckl, A.; Oberwahrenbrock, T.; Lolies, M.; Stein, S.; Plate, K.H.; Reiss, Y.; Rödel, F.; Sevenich, L.
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2021Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression
Rappl, P.; Rösser, S.; Maul, P.; Bauer, R.; Huard, A.; Schreiber, Y.; Thomas, D.; Geisslinger, G.; Jakobsson, P.-J.; Weigert, A.; Brüne, B.; Schmid, T.
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2021Injectable drug delivery systems of doxorubicin revisited: In vitro-in vivo relationships using human clinical data
Modh, H.; Fang, D.J.; Ou, Y.H.; Yau, J.N.N.; Kovshova, T.; Nagpal, S.; Knoll, J.; Wallenwein, C.M.; Maiti, K.; Bhowmick, S.; Gelperina, S.; Pastorin, G.; Wacker, M.G.
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2021Insights into the genome and secretome of Fusarium metavorans DSM105788 by cultivation on agro-residual biomass and synthetic nutrient sources
Brandt, S.C.; Brognaro, H.; Ali, A.; Ellinger, B.; Maibach, K.; Rühl, M.; Wrenger, C.; Schlüter, H.; Schäfer, W.; Betzel, C.; Janssen, S.; Gand, M.
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2021Interpretation of cluster structures in pain-related phenotype data using explainable artificial intelligence (XAI)
Lötsch, J.; Malkusch, S.
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2021Introduction to the eqipd quality system
Bespalov, A.; Bernard, R.; Gilis, A.; Gerlach, B.; Guillén, J.; Castagné, V.; Lefevre, I.A.; Ducrey, F.; Monk, L.; Bongiovanni, S.; Altevogt, B.; Arroyo-Araujo, M.; Bikovski, L.; Bruin, N. de; Castaños-Vélez, E.; Dityatev, A.; Emmerich, C.H.; Fares, R.; Ferland-Beckham, C.; Froger-Colléaux, C.; Gailus-Durner, V.; Hölter, S.M.; Hofmann, M.C.J.; Kabitzke, P.; Kas, M.J.H.; Kurreck, C.; Moser, P.; Pietraszek, M.; Popik, P.; Potschka, H.; Oca, E.P.M. de; Restivo, L.; Riedel, G.; Ritskes-Hoitinga, M.; Samardzic, J.; Schunn, M.; Stöger, C.; Voikar, V.; Vollert, J.; Wever, K.E.; Wuyts, K.; Macleod, M.R.; Dirnagl, U.; Steckler, T.
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2021Iron-Bound Lipocalin-2 Protects Renal Cell Carcinoma from Ferroptosis
Meier, J.K.; Schnetz, M.; Beck, S.; Schmid, T.; Dominguez, M.; Kalinovic, S.; Daiber, A.; Brüne, B.; Jung, M.
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2021Lactate dehydrogenase B regulates macrophage metabolism in the tumor microenvironment
Frank, A.-C.; Raue, R.; Fuhrmann, D.C.; Sirait-Fischer, E.; Reuse, C.; Weigert, A.; Lütjohann, D.; Hiller, K.; Syed, S.N.; Brüne, B.
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2021Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages
Mota, A.C.; Dominguez, M.; Weigert, A.; Snodgrass, R.G.; Namgaladze, D.; Brüne, B.
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2021Machine-Learning Points at Endoscopic, Quality of Life, and Olfactory Parameters as Outcome Criteria for Endoscopic Paranasal Sinus Surgery in Chronic Rhinosinusitis
Lötsch, J.; Hintschich, C.A.; Petridis, P.; Pade, J.; Hummel, T.
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2021Mapping Chromone-3-Phenylcarboxamide Pharmacophore: Quid Est Veritas?
Mesiti, F.; Gaspar, A.; Chavarria, D.; Maruca, A.; Rocca, R.; Gil Martins, E.; Barreiro, S.; Silva, R.; Fernandes, C.; Gul, S.; Keminer, O.; Alcaro, S.; Borges, F.
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2021Mastiha has efficacy in immune-mediated inflammatory diseases through a microRNA-155 Th17 dependent action
Amerikanou, C.; Papada, E.; Gioxari, A.; Smyrnioudis, I.; Kleftaki, S.-A.; Valsamidou, E.; Bruns, V.; Banerjee, R.; Trivella, M.G.; Milic, N.; Medic-Stojanoska, M.; Gastaldelli, A.; Kannt, A.; Dedoussis, G.V.; Kaliora, A.C.
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2021Measuring treatment effect on psoriatic arthritis-related domains: insights from the SPIRIT-H2H study at weeks 24 and 52
Behrens, F.; Leage, S.L.; Sapin, C.; Baou, C.E.; Torre, I. De La; Meszaros, G.; Schett, G.; Combe, B.; Bosch, F. van den; Gossec, L.
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2021A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization
Schultz, B.; Zaliani, A.; Ebeling, C.; Reinshagen, J.; Bojkova, D.; Lage-Rupprecht, V.; Karki, R.; Lukassen, S.; Gadiya, Y.; Ravindra, N.G.; Das, S.; Baksi, S.; Domingo-Fernandez, D.; Lentzen, M.; Strivens, M.; Raschka, T.; Cinatl, J.; DeLong, L.N.; Gribbon, P.; Geisslinger, G.; Ciesek, S.; Dijk, D. van; Gardner, S.; Kodamullil, A.T.; Fröhlich, H.; Peitsch, M.; Jacobs, M.; Hoeng, J.; Eils, R.; Claussen, C.; Hofmann-Apitius, M.
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2021Mitochondrial Protein Abundance Gradients Require the Distribution of Separated Mitochondria
Bollmann, F.; Dohrke, J.-N.; Wurm, C.A.; Jans, D.C.; Jakobs, S.
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2021Mitofusin 2 Deficiency Causes Pro-Inflammatory Effects in Human Primary Macrophages
Khodzhaeva, V.; Schreiber, Y.; Geisslinger, G.; Brandes, R.P.; Brüne, B.; Namgaladze, D.
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2021Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer
Kienzl, M.; Hasenoehrl, C.; Maitz, K.; Sarsembayeva, A.; Taschler, U.; Valadez-Cosmes, P.; Kindler, O.; Ristic, D.; Raftopoulou, S.; Santiso, A.; Bärnthaler, T.; Brcic, L.; Hahnefeld, L.; Gurke, R.; Thomas, D.; Geisslinger, G.; Kargl, J.; Schicho, R.
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2021Nanomedicine at the crossroads - A quick guide for IVIVC
Mast, M.-P.; Modh, H.; Champanhac, C.; Wang, J.-W.; Storm, G.; Krämer, J.; Mailänder, V.; Pastorin, G.; Wacker, M.G.
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2021Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation
Woo, M.S.; Ufer, F.; Rothammer, N.; Liberto, G. di; Binkle, L.; Haferkamp, U.; Sonner, J.K.; Engler, J.B.; Hornig, S.; Bauer, S.; Wagner, I.; Egervari, K.; Raber, J.; Duvoisin, R.M.; Pless, O.; Merkler, D.; Friese, M.A.
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2021A novel approach for studying mast cell–driven disorders: Mast cells derived from induced pluripotent stem cells
Luo, Y.; Fernandez Vallone, V.; He, J.; Frischbutter, S.; Kolkhir, P.; Moñino-Romero, S.; Stachelscheid, H.; Streu-Haddad, V.; Maurer, M.; Siebenhaar, F.; Scheffel, J.
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2021Novel Inhibitors of Nicotinamide-N-Methyltransferase for the Treatment of Metabolic Disorders
Kannt, A.; Rajagopal, S.; Hallur, M.S.; Swamy, I.; Kristam, R.; Dhakshinamoorthy, S.; Czech, J.; Zech, G.; Schreuder, H.; Ruf, S.
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2021Nutrigenetic Interactions Might Modulate the Antioxidant and Anti-Inflammatory Status in Mastiha-Supplemented Patients With NAFLD
Kanoni, S.; Kumar, S.; Amerikanou, C.; Kurth, M.J.; Stathopoulou, M.G.; Bourgeois, S.; Masson, C.; Kannt, A.; Cesarini, L.; Kontoe, M.-S.; Milanovic, M.; Roig, F.J.; Beribaka, M.; Campolo, J.; Jiménez-Hernández, N.; Milošević, N.; Llorens, C.; Smyrnioudis, I.; Francino, M.P.; Milic, N.; Kaliora, A.C.; Trivella, M.G.; Ruddock, M.W.; Medić-Stojanoska, M.; Gastaldelli, A.; Lamont, J.; Deloukas, P.; Dedoussis, G.V.; Visvikis-Siest, S.
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2021Optimal distribution-preserving downsampling of large biomedical data sets (opdisDownsampling)
Lötsch, J.; Malkusch, S.; Ultsch, A.
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2021Oral biopharmaceutics tools: Recent progress from partnership through the Pharmaceutical Education and Research with Regulatory Links collaboration
O'Dwyer, P.J.; Box, K.J.; Dressman, J.; Griffin, B.T.; Henze, L.J.; Litou, C.; Pentafragka, C.; Statelova, M.; Vertzoni, M.; Reppas, C.
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2021Oxaliplatin Causes Transient Changes in TRPM8 Channel Activity
Rimola, V.; Osthues, T.; Königs, V.; Geißlinger, G.; Sisignano, M.
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2021Pharmacological Activation of p53 during Human Monocyte to Macrophage Differentiation Attenuates Their Pro-Inflammatory Activation by TLR4, TLR7 and TLR8 Agonists
Namgaladze, D.; Brüne, B.
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2021Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling to Support Waivers of In Vivo Clinical Studies: Current Status, Challenges, and Opportunities
Loisios-Konstantinidis, I.; Dressman, J.
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2021Predicting drug release and degradation kinetics of long-acting microsphere formulations of tacrolimus for subcutaneous injection
Gao, G.F.; Ashtikar, M.; Kojima, R.; Yoshida, T.; Kaihara, M.; Tajiri, T.; Shanehsazzadeh, S.; Modh, H.; Wacker, M.G.
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2021Prediction of plasma profiles of a weakly basic drug after administration of omeprazole using PBPK modeling
Segregur, D.; Mann, J.; Moir, A.; Karlsson, E.M.; Dressman, J.
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2021Prodromal sensory neuropathy in Pink1-/-SNCAA53T double mutant Parkinson mice
Valek, L.; Tran, B.; Wilken-Schmitz, A.; Trautmann, S.; Heidler, J.; Schmid, T.; Brüne, B.; Thomas, D.; Deller, T.; Geisslinger, G.; Auburger, G.; Tegeder, I.
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2021Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells
Faudone, G.; Bischoff-Kont, I.; Rachor, L.; Willems, S.; Zhubi, R.; Kaiser, A.; Chaikuad, A.; Knapp, S.; Fürst, R.; Heering, J.; Merk, D.
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2021Prostanoids and Resolution of Inflammation - Beyond the Lipid-Mediator Class Switch
Schmid, T.; Brüne, B.
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2021Proton-Sensing GPCRs in Health and Disease
Sisignano, M.; Fischer, M.J.M.; Geisslinger, G.
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2021A quality improvement study on the reduction of central venous catheter-associated bloodstream infections by use of self-disinfecting venous access caps (STERILE)
Cruz-Aguilar, R.; Carney, J.; Mondaini, V.; Vehreschild, M.J.G.T.; Griskaitis, M.; Salmanton-García, J.; Böll, B.; Kochanek, M.; Seifert, H.; Biehl, L.M.; Farowski, F.
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2021Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice
Schmitz, K.; Trautmann, S.; Hahnefeld, L.; Fischer, C.; Schreiber, Y.; Wilken-Schmitz, A.; Gurke, R.; Brunkhorst, R.; Werner, E.R.; Watschinger, K.; Wicker, S.; Thomas, D.; Geisslinger, G.; Tegeder, I.
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2021A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection
Ellinger, B.; Bojkova, D.; Zaliani, A.; Cinatl, J.; Claussen, C.; Westhaus, S.; Keminer, O.; Reinshagen, J.; Kuzikov, M.; Wolf, M.; Geisslinger, G.; Gribbon, P.; Ciesek, S.
Zeitschriftenaufsatz
2021Self-Ratings of Olfactory Function and Their Relation to Olfactory Test Scores. A Data Science-Based Analysis in Patients with Nasal Polyposis
Lötsch, J.; Hintschich, C.A.; Petridis, P.; Pade, J.; Hummel, T.
Zeitschriftenaufsatz
2021Sodium Bituminosulfonate Used to Treat Rosacea Modulates Generation of Inflammatory Mediators by Primary Human Neutrophils
Schiffmann, S.; Gunne, S.; Henke, M.; Ulshöfer, T.; Steinhilber, D.; Sethmann, A.; Parnham, M.J.
Zeitschriftenaufsatz
2021Sphingolipid and Endocannabinoid Profiles in Adult Attention Deficit Hyperactivity Disorder
Brunkhorst-Kanaan, N.; Trautmann, S.; Schreiber, Y.; Thomas, D.; Kittel-Schneider, S.; Gurke, R.; Geisslinger, G.; Reif, A.; Tegeder, I.
Zeitschriftenaufsatz
2021Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain
Ni, X.; Schröder, M.; Olieric, V.; Sharpe, M.E.; Hernandez-Olmos, V.; Proschak, E.; Merk, D.; Knapp, S.; Chaikuad, A.
Zeitschriftenaufsatz
2021Sustained-release hot melt extrudates of the weak acid TMP-001: A case study using PBB modelling
Jung, F.; Thurn, M.; Krollik, K.; Li, D.; Dressman, J.; Alig, E.; Fink, L.; Schmidt, M.U.; Wacker, M.G.
Zeitschriftenaufsatz
2021Targeting autophagy in disease: established and new strategies
Kocak, M.; Ezazi Erdi, S.; Jorba, G.; Maestro, I.; Farrés, J.; Kirkin, V.; Martinez, A.; Pless, O.
Review
2021Towards Virtual Bioequivalence Studies for Oral Dosage Forms Containing Poorly Water-Soluble Drugs: A Physiologically Based Biopharmaceutics Modeling (PBBM) Approach
Kambayashi, A.; Dressman, J.B.
Zeitschriftenaufsatz
2021Trehalose Reduces Nerve Injury Induced Nociception in Mice but Negatively Affects Alertness
Kraft, V.; Schmitz, K.; Wilken-Schmitz, A.; Geisslinger, G.; Sisignano, M.; Tegeder, I.
Zeitschriftenaufsatz
2021Visually guided preprocessing of bioanalytical laboratory data using an interactive R notebook (pguIMP)
Malkusch, S.; Hahnefeld, L.; Gurke, R.; Lötsch, J.
Zeitschriftenaufsatz
2021X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease
Günther, S.; Reinke, P.Y.A.; Fernández-García, Y.; Lieske, J.; Lane, T.J.; Ginn, H.M.; Koua, F.H.M.; Ehrt, C.; Ewert, W.; Oberthuer, D.; Yefanov, O.; Meier, S.; Lorenzen, K.; Krichel, B.; Kopicki, J.-D.; Gelisio, L.; Brehm, W.; Dunkel, I.; Seychell, B.; Gieseler, H.; Norton-Baker, B.; Escudero-Pérez, B.; Domaracky, M.; Saouane, S.; Tolstikova, A.; White, T.A.; Hänle, A.; Groessler, M.; Fleckenstein, H.; Trost, F.; Galchenkova, M.; Gevorkov, Y.; Li, C.; Awel, S.; Peck, A.; Barthelmess, M.; Schlünzen, F.; Xavier, P.L.; Werner, N.; Andaleeb, H.; Ullah, N.; Falke, S.; Srinivasan, V.; Franca, B.A.; Schwinzer, M.; Brognaro, H.; Rogers, C.; Melo, D.; Zaitseva-Doyle, J.J.; Knoska, J.; Peña-Murillo, G.E.; Mashhour, A.R.; Hennicke, V.; Fischer, P.; Hakanpää, J.; Meyer, J.; Gribbon, P.; Ellinger, B.; Kuzikov, M.; Wolf, M.; Beccari, A.R.; Bourenkov, G.; Stetten, D.V.; Pompidor, G.; Bento, I.; Panneerselvam, S.; Karpics, I.; Schneider, T.R.; Garcia-Alai, M.M.; Niebling, S.; Günther, C.; Schmidt, C.; Schubert, R.
Zeitschriftenaufsatz
2021Xenocoumacin 2 reduces protein biosynthesis and inhibits inflammatory and angiogenesis-related processes in endothelial cells
Erkoc, P.; Schmitt, M.; Ingelfinger, R.; Bischoff-Kont, I.; Kopp, L.; Bode, H.B.; Schiffmann, S.; Fürst, R.
Zeitschriftenaufsatz