Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2020An automated and high-throughput-screening compatible pluripotent stem cell-based test platform for developmental and reproductive toxicity assessment of small molecule compounds
Witt, Gesa; Keminer, Oliver; Leu, Jennifer; Tandon, Rashmi; Meiser, Ina; Willing, Anne; Winschel, Ingo; Abt, Jana-Christin; Brändl, Björn; Sébastien, Isabelle; Friese, Manuel A.; Müller, Franz Josef; Neubauer, Julia C.; Claussen, Carsten; Zimmermann, Heiko; Gribbon, Philip; Pless, Ole
Journal Article
2020Bicistronic expression and differential localization of proteins in insect cells and Drosophila suzukii using picornaviral 2A peptides
Schwirz, J.; Yan, Y.; Franta, Z.; Schetelig, M.F.
Journal Article
2020Bildgebung bei der Psoriasisarthritis und Aspekte der röntgenologischen Progression
Baraliakos, X.; Kleyer, A.; Simon, D.; Köhm, M.; Ohrndorf, S.; Sewerin, P.
Journal Article
2020Bioavailability of silver from wastewater and planktonic food borne silver nanoparticles in the rainbow trout Oncorhynchus mykiss
Zeumer, Richard; Hermsen, Lara; Kägi, Ralf; Kühr, Sebastian; Knopf, Burkhard; Schlechtriem, Christian
Journal Article
2020Bioconcentration, metabolism and spatial distribution of 14C‐labelled laurate in the freshwater amphipod Hyalella Azteca
Raths, Johannes; Kühr, Sebastian; Schlechtriem, Christian
Journal Article
2020Biodegradation testing of volatile hydrophobic chemicals in water-sediment systems - Experimental developments and challenges
Shresta, Prasit; Meisterjahn, Boris; Hughes, Christopher B.; Mayer, Philipp; Birch, Heidi; Hennecke, Dieter
Journal Article
2020Biotransformation Changes Bioaccumulation and Toxicity of Diclofenac in Aquatic Organisms
Fu, Qiuguo; Fedrizzi, Davide; Kosfeld, Verena; Schlechtriem, Christian; Ganz, Vera; Derrer, Samuel; Rentsch, Daniel; Hollender, Juliane
Journal Article
2020Chemicals of emerging concern in marine specimens of the German Environmental Specimen Bank
Fliedner, Annette; Rüdel, Heinz; Dreyer, Annekatrin; Pirntke, Ulrike; Koschorreck, Jan
Journal Article
2020Chronic effects of wastewater-borne silver and titanium dioxide nanoparticles on the rainbow trout (Oncorhynchus mykiss)
Zeumer, Richard; Galhano, Victor; Monteiro, Marta S.; Kühr, Sebastian; Knopf, Burkhard; Meisterjahn, Boris; Soares, Amadeu M.V.M.; Loureiro, Susana; Lopes, Isabel; Schlechtriem, Christian
Journal Article
2020Collecting data through high throughput in vitro early toxicity and off-target liability assays to rapidly identify limitations of novel thyromimetics
Runfola, M.; Sestito, S.; Gul, S.; Chiellini, G.; Rapposelli, S.
Journal Article
2020Comparative proteome and metabolome analyses of latex-exuding and non-exuding Taraxacum koksaghyz roots provide insights into laticifer biology
Benninghaus, V.A.; Deenen, N. van; Müller, B.; Roelfs, K.-U.; Lassowskat, I.; Finkemeier, I.; Prüfer, D.; Schulze Gronover, C.
Journal Article
2020Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities
Teyra, J.; Ernst, A.; Singer, A.; Sicheri, F.; Sidhu, S.S.
Journal Article
2020Current projection methods-induced biases at subgroup detection for machine-learning based data-analysis of biomedical data
Lötsch, J.; Ultsch, A.
Journal Article
2020Data-science-based subgroup analysis of persistent pain during 3 years after breast cancer surgery: A prospective cohort study
Lötsch, J.; Ultsch, A.; Kalso, E.
Journal Article
2020Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis
Runfola, M.; Sestito, S.; Bellusci, L.; Pietra, V. la; D'Amore, V.M.; Kowalik, M.A.; Chiellini, G.; Gul, S.; Perra, A.; Columbano, A.; Marinelli, L.; Novellino, E.; Rapposelli, S.
Journal Article
2020Detection of biomarkers to differentiate endocrine disruption from hepatotoxicity in zebrafish (Danio rerio) using proteomics
Ayobahan, Steve U.; Eilebrecht, Sebastian; Baumann, Lisa; Teigeler, Matthias; Hollert, Henner; Kalkhof, Stefan; Eilebrecht, Elke; Schäfers, Christoph
Journal Article
2020Development of a method to determine the bioaccumulation of manufactured nanomaterials in filtering organisms (Bivalvia). Final Report
Schlechtriem, Christian; Knopf, Burkhard; Kühr, Sebastian; Meisterjahn, Boris; Schröder, Nicola
Report
2020Development of a test method for transformation of veterinary pharmaceuticals and biocides in anaerobic liquid manure
Junker, Thomas; Atorf, Cornelia; Berkner, Silvia; Düring, Rolf-Alexander; Hennecke, Dieter; Herrchen, Monika; Konradi, Sabine; Merrettig‑Bruns, Ute; Römbke, Jörg; Wagner, Julia; Weinfurtner, Karlheinz
Journal Article
2020Distribution Optimization: An evolutionary algorithm to separate Gaussian mixtures
Lerch, F.; Ultsch, A.; Lötsch, J.
Journal Article
2020The disturbed iron phenotype of tumor cells and macrophages in renal cell carcinoma influences tumor growth
Schnetz, M.; Meier, J.K.; Rehwald, C.; Mertens, C.; Urbschat, A.; Tomat, E.; Akam, E.A.; Baer, P.; Roos, F.C.; Brüne, B.; Jung, M.
Journal Article
2020Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast
Schierle, S.; Helmstädter, M.; Schmidt, J.; Hartmann, M.; Horz, M.; Kaiser, A.; Weizel, L.; Heitel, P.; Proschak, A.; Hernandez-Olmos, V.; Proschak, E.; Merk, D.
Journal Article
2020Establishing virtual bioequivalence and clinically relevant specifications using in vitro biorelevant dissolution testing and physiologically-based population pharmacokinetic modeling. Case example: Naproxen
Loisios-Konstantinidis, I.; Cristofoletti, R.; Fotaki, N.; Turner, D.B.; Dressman, J.
Journal Article
2020Evaluation of potential environmental toxicity of polymeric nanomaterials and surfactants
Hering, Indra; Eilebrecht, Elke; Parnham, Michael J.; Günday-Türeli, Nazende; Türeli, Akif Emre; Weiler, Marc; Schäfers, Christoph; Fenske, Martina; Wacker, Matthias G.
Journal Article
2020Evidence of SARS-CoV-2 Infection in Returning Travelers from Wuhan, China
Ciesek, Sandra
Journal Article
2020Factors determining microbial colonization of liquid nitrogen storage tanks used for archiving biological samples
Bajerski, F.; Bürger, A.; Glasmacher, B.; Keller, E.R.J.; Müller, K.; Mühldorfer, K.; Nagel, M.; Rüdel, H.; Müller, T.; Schenkel, J.; Overmann, J.
Journal Article
2020Fate of acrylamide during coffee roasting and in vitro digestion assessed with carbon 14- and carbon 13-labeled materials
Badoud, Flavia; Göckener, Bernd; Severin, Kevin; Ernest, Marion; Romero, Roman; Alzieu, Thibaut; Glabasnia, Arne; Hamel, Jonas; Bücking, Mark; Delatour, Thierry
Journal Article
2020Fate of Chlorpropham during High-Temperature Processing of Potatoes
Göckener, Bernd; Kotthoff, Matthias; Kling, Hans-Willi; Bücking, Mark
Journal Article
2020A field study in support of the monitoring of priority substances in German freshwater fish: Derivation of fillet-to-whole fish conversion factors
Rüdel, Heinz; Radermacher, Georg; Fliedner, Annette; Lohmann, Nina; Duffek, Anja
Journal Article
2020Flow cytometry-based system for screening of lignin peroxidase mutants with higher oxidative stability
Ilić Đurđić, K.; Ece, S.; Ostafe, R.; Vogel, S.; Balaž, A.M.; Schillberg, S.; Fischer, R.; Prodanovic, R.
Journal Article
2020Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme
Marbach-Breitrück, E.; Kutzner, L.; Rothe, M.; Gurke, R.; Schreiber, Y.; Reddanna, P.; Schebb, N.-H.; Stehling, S.; Wieler, L.H.; Heydeck, D.; Kuhn, H.
Journal Article
2020The Fundamental Clustering and Projection Suite (FCPS)
Ultsch, A.; Lötsch, J.
Journal Article
2020Gene expression variability between randomly and targeted transgene integration events in tobacco suspension cell lines
Kirchhoff, Janina; Schiermeyer, Andreas; Schneider, Katja; Fischer, Rainer; Ainley, W. Michael; Webb, Steven R.; Schinkel, Helga; Schillberg, Stefan
Journal Article
2020Glucagon-like peptide 1 levels predict cardiovascular risk in patients with acute myocardial infarction
Kahles, F.; Rückbeil, M.V.; Mertens, R.W.; Foldenauer, A.C.; Arrivas, M.C.; Moellmann, J.; Lebherz, C.; Biener, M.; Giannitsis, E.; Katus, H.A.; Marx, N.; Lehrke, M.
Journal Article
2020A head-to-head comparison of the efficacy and safety of ixekizumab and adalimumab in biological-naïve patients with active psoriatic arthritis: 24-week results of a randomised, open-label, blinded-assessor trial
Mease, P.J.; Smolen, J.S.; Behrens, F.; Nash, P.; Liu Leage, S.; Li, L.; Tahir, H.; Gooderham, M.; Krishnan, E.; Liu-Seifert, H.; Emery, P.; Pillai, S.G.; Helliwell, P.S.
Journal Article
2020Identification and molecular analysis of interaction sites in the MtSEO-F1 protein involved in forisome assembly
Rose, J.; Visser, F.; Müller, B.; Senft, M.; Groscurth, S.; Sicking, K.F.; Twyman, R.M.; Prüfer, D.; Noll, G.A.
Journal Article
2020Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign
Linciano, P.; Cullia, G.; Borsari, C.; Santucci, M.; Ferrari, S.; Witt, G.; Gul, S.; Kuzikov, M.; Ellinger, B.; Santarem, N.; Cordeiro da Silva, A.; Conti, P.; Bolognesi, M.L.; Roberti, M.; Prati, F.; Bartoccini, F.; Retini, M.; Piersanti, G.; Cavalli, A.; Goldoni, L.; Bertozzi, S.M.; Bertozzi, F.; Brambilla, E.; Rizzo, V.; Piomelli, D.; Pinto, A.; Bandiera, T.; Costi, M.P.
Journal Article
2020Impact of wastewater-borne nanoparticles of silver and titanium dioxide on the swimming behaviour and biochemical markers of Daphnia magna: An integrated approach
Galhano, Victor; Hartmann, Sarah; Monteiro, Marta S.; Zeumer, Richard; Mozhayeva, Darya; Steinhoff, Benedikt; Müller, Katharina; Prenzel, Kirsten; Kunze, Jan; Kuhnert, Klaus-Dieter; Schönherr, Holger; Engelhard, Carsten; Schlechtriem, Christian; Loureiro, Susana; Soares, Amadeu M.V.M.; Witte, Klaudia; Lopes, Isabel
Journal Article
2020Implementation of lipidomics in clinical routine: Can fluoride/citrate blood sampling tubes improve preanalytical stability?
Hahnefeld, L.; Gurke, R.; Thomas, D.; Schreiber, Y.; Schäfer, S.M.G.; Trautmann, S.; Snodgrass, I.F.; Kratz, D.; Geisslinger, G.; Ferreiros, N.
Journal Article
2020Individual therapeutic DAS28-dcrit responses differentiate between effectiveness of rheumatoid arthritis therapies and reflect patient-reported outcomes
Koehm, M.; McIntosh, M.J.; Hofmann, M.W.; Abraham, V.; Gabay, C.; Choy, E.H.; Kavanaugh, A.; Burkhardt, H.; Behrens, F.
Journal Article
2020Inhibition of histone acetylation and deacetylation enzymes affects longevity, development, and fecundity in the pea aphid (Acyrthosiphon pisum)
Kirfel, P.; Skaljac, M.; Grotmann, J.; Kessel, T.; Seip, M.; Michaelis, K.; Vilcinskas, A.
Journal Article
2020Innovative Optical-Sensing Technology for the Online Fouling Characterization of Silicon Carbide Membranes during the Treatment of Oily Water
Ebrahimi, M.; Schmidt, A.A.; Kaplan, C.; Schmitz, O.; Czermak, P.
Journal Article
2020The insect antimicrobial peptide cecropin A disrupts uropathogenic Escherichia coli biofilms
Kalsy, M.; Tonk, M.; Hardt, M.; Dobrindt, U.; Zdybicka-Barabas, A.; Cytrynska, M.; Vilcinskas, A.; Mukherjee, K.
Journal Article
2020Insektizide in Böden unterschiedlicher Bewirtschaftung
Leisner, Jörg; Guhl, Barbara; Hindersmann, Benjamin; Göckener, Bernd
Journal Article
2020The iron load of lipocalin-2 (LCN-2) defines its pro-tumour function in clear-cell renal cell carcinoma
Rehwald, C.; Schnetz, M.; Urbschat, A.; Mertens, C.; Meier, J.K.; Bauer, R.; Baer, P.; Winslow, S.; Roos, F.C.; Zwicker, K.; Huard, A.; Weigert, A.; Brüne, B.; Jung, M.
Journal Article
2020Local fixation of antibiotics with fibrin spray on soft tissues: Experimental study on the relevance of the application techniques
Verboket, R.; Marzi, I.; Fleck, S.C.; Frank, J.; Janko, M.
Journal Article
2020Machine-learned identification of psychological subgroups with relation to pain interference in patients after breast cancer treatments
Sipilä, R.; Kalso, E.; Lötsch, J.
Journal Article
2020Machine-learning-based knowledge discovery in rheumatoid arthritis-related registry data to identify predictors of persistent pain
Lötsch, J.; Alfredsson, L.; Lampa, J.
Journal Article
2020Machine-learning-derived rules set excludes risk of Parkinson’s disease in patients with olfactory or gustatory symptoms with high accuracy
Lötsch, J.; Haehner, A.; Hummel, T.
Journal Article
2020The Major Floral Promoter NtFT5 in Tobacco (Nicotiana tabacum) is a Promising Target for Crop Improvement
Schmidt, F.J.; Zimmermann, M.M.; Wiedmann, D.R.; Lichtenauer, S.; Grundmann, L.; Muth, J.; Twyman, R.M.; Prüfer, D.; Noll, G.A.
Journal Article
2020Measuring pH and Buffer Capacity in Fluids Aspirated from the Fasted Upper Gastrointestinal Tract of Healthy Adults
Litou, C.; Psachoulias, D.; Vertzoni, M.; Dressman, J.; Reppas, C.
Journal Article
2020Membrane-based steric exclusion chromatography for the purification of a recombinant baculovirus and its application for cell therapy
Lothert, K.; Sprick, G.; Beyer, F.; Lauria, G.; Czermak, P.; Wolff, M.W.
Journal Article
2020MicroRNAs regulate innate immunity against uropathogenic and commensal-like Escherichia coli infections in the surrogate insect model Galleria mellonella
Mukherjee, K.; Amsel, D.; Kalsy, M.; Billion, A.; Dobrindt, U.; Vilcinskas, A.
Journal Article
2020Molecular farming - the slope of enlightenment
Fischer, R.; Buyel, J.F.
Journal Article
2020The omega-3 lipid 17,18-EEQ sensitizes TRPV1 and TRPA1 in sensory neurons through the prostacyclin receptor (IP)
Schäfer, S.M.G.; Sendetski, M.; Angioni, C.; Nüsing, R.; Geisslinger, G.; Scholich, K.; Sisignano, M.
Journal Article
2020Opportunities to debottleneck the downstream processing of the oncolytic measles virus
Loewe, D.; Dieken, H.; Grein, T.A.; Weidner, T.; Salzig, D.; Czermak, P.
Journal Article
2020Optimizing product quality in molecular farming
Schiermeyer, Andreas
Journal Article
2020Persistent, mobile and toxic substances in the environment: A spotlight on current research and regulatory activities
Rüdel, Heinz; Körner, Wolfgang; Letzel, Thomas; Neumann, Michael; Nödler, Karsten; Reemtsma, Thorsten
Journal Article
2020Predicting human pharmacokinetics of liposomal temoporfin using a hybrid in silico model
Jablonka, L.; Ashtikar, M.; Gao, G.F.; Thurn, M.; Modh, H.; Wang, J.-W.; Preuß, A.; Scheglmann, D.; Albrecht, V.; Röder, B.; Wacker, M.G.
Journal Article
2020The production of isoprene from cellulose using recombinant Clostridium cellulolyticum strains expressing isoprene synthase
Janke, C.; Gaida, S.; Jennewein, S.
Journal Article
2020Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper
Jiso, A.; Kittiwisut, S.; Chantakul, R.; Yuenyongsawad, S.; Putchakarn, S.; Schäberle, T.F.; Temkitthaworn, P.; Ingkaninan, K.; Chaithirayanon, K.; Plubrukarn, A.
Journal Article
2020Rare Loss-of-Function Mutation in SERPINA3 in Generalized Pustular Psoriasis
Frey, S.; Sticht, H.; Wilsmann-Theis, D.; Gerschütz, A.; Wolf, K.; Löhr, S.; Haskamp, S.; Frey, B.; Hahn, M.; Ekici, A.B.; Uebe, S.; Thiel, C.; Reis, A.; Burkhardt, H.; Behrens, F.; Köhm, M.; Rech, J.; Schett, G.; Assmann, G.; Kingo, K.; Koks, S.; Mössner, R.; Prinz, J.C.; Oji, V.; Schulz, P.; Muñoz, L.E.; Kremer, A.E.; Wenzel, J.; Hüffmeier, U.
Journal Article
2020Retrospective analysis of cyclic volatile methylsiloxanes in archived German fish samples covering a period of two decades
Radermacher, Georg; Rüdel, Heinz; Wesch, Charlotte; Böhnhardt, Anna; Koschorreck, Jan
Journal Article
2020S1P d20:1, an endogenous modulator of S1P d18:1/S1P2-dependent signaling
Vutukuri, R.; Koch, A.; Trautmann, S.; Schreiber, Y.; Thomas, D.; Mayser, F.; Meyer zu Heringdorf, D.; Pfeilschifter, J.; Pfeilschifter, W.; Brunkhorst, R.
Journal Article
2020S1PR4-dependent CCL2 production promotes macrophage recruitment in a murine psoriasis model
Schuster, C.; Huard, A.; Sirait-Fischer, E.; Dillmann, C.; Brüne, B.; Weigert, A.
Journal Article
2020Saturation mutagenesis to improve the degradation of azo dyes by versatile peroxidase and application in form of VP-coated yeast cell walls
Ilić Đurđić, K.; Ostafe, R.; Đurđević Đelmaš, A.; Popović, N.; Schillberg, S.; Fischer, R.; Prodanovic, R.
Journal Article
2020Schulung von Medizinischen Fachangestellten bei hausärztlichen Forschungsprojekten. Wissensgewinn und Unterschiede zwischen einer Präsenzschulung und dem Selbststudium eines Schulungshandbuches
Mergenthal, K.; Schulz-Rothe, S.; Siebenhofer, A.; Gerlach, F.M.; Rossmanith, T.; Petersen, J.J.
Journal Article
2020Seasonal phenotype-specific expression of microRNAs during metamorphosis in the European map butterfly Araschnia levana
Mukherjee, K.; Baudach, A.; Vogel, H.; Vilcinskas, A.
Journal Article
2020Seasonal variability in metal and metalloid burdens of mussels: Using data from the German Environmental Specimen Bank to evaluate implications for long-term mussel monitoring programs
Knopf, Burkhard; Fliedner, Annette; Radermacher, Georg; Rüdel, Heinz; Paulus, Martin; Pirntke, Ulrike; Koschorreck, Jan
Journal Article
2020Silencing of the DNA methyltransferase 1 associated protein 1 (DMAP1) gene in the invasive ladybird Harmonia axyridis implies a role of the DNA methyltransferase 1-DMAP1 complex in female fecundity
Gegner, J.; Gegner, T.; Vogel, H.; Vilcinskas, A.
Journal Article
2020Testing the bioaccumulation of manufactured nanomaterials in the freshwater bivalve Corbicula fluminea using a new test method
Kühr, Sebastian; Meisterjahn, Boris; Schröder, Nicola; Knopf, Burkhard; Völker, Doris; Schwirn, Kathrin; Schlechtriem, Christian
Journal Article
2020Therapie der Psoriasisarthritis
Köhm, M.; Behrens, F.
Journal Article
2020A tiered high-throughput screening approach for evaluation of estrogen and androgen receptor modulation by environmentally relevant bisphenol A substitutes
Keminer, Oliver; Teigeler, Matthias; Kohler, Manfred; Wenzel, Andrea; Arning, Jürgen; Kaßner, Franziska; Windshügel, Björn; Eilebrecht, Elke
Journal Article
2020Turbidimetry and dielectric spectroscopy as process analytical technologies for mammalian and insect cell cultures
Käßer, L.; Zitzmann, J.; Grein, T.; Weidner, T.; Salzig, D.; Czermak, P.
Conference Paper
20193D Printed Modular Immunofiltration Columns for Frequency Mixing-Based Multiplex Magnetic Immunodetection
Achtsnicht, S.; Tödter, J.; Niehues, J.; Telöken, M.; Offenhäusser, A.; Krause, H.J.; Schröper, F.
Journal Article
20194 Ds in health research - working together toward rapid precision medicine
Niederberger, E.; Parnham, M.J.; Maas, J.; Geisslinger, G.
Journal Article
20195-Amino-1-β-D-Ribofuranosyl-Imidazole-4-Carboxamide (AICAR) Reduces Peripheral Inflammation by Macrophage Phenotype Shift
Martin, L.M.; Möller, M.; Weiss, U.; Russe, O.Q.; Scholich, K.; Pierre, S.; Geisslinger, G.; Niederberger, E.
Journal Article
2019α-Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease
Moreno-Cinos, C.; Sassetti, E.; Salado, I.G.; Witt, G.; Benramdane, S.; Reinhardt, L.; Cruz, C.D.; Joossens, J.; Veken, P. Van der; Brötz-Oesterhe, H.; Tammela, P.; Winterhalter, M.; Gribbon, P.; Windshügel, B.; Augustyns, K.
Journal Article
2019Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform
Moraes, C.B.; Witt, G.; Kuzikov, M.; Ellinper, B.; Calogeropoulou, T.; Prousis, K.C.; Mangani, S.; Pisa, F. di; Landi, G.; Dello Lacono, L.; Pozzi, C.; Freitas, L.H.; Pascoalino, B.D.; Bertolacini, C.P.; Behrens, B.; Keminer, O.; Leu, J.; Wolf, M.; Reinshagen, J.; Cordeiro-da-Silva, A.; Santarem, N.; Venturelli, A.; Wrigley, S.; Karunakaran, D.; Kebede, B.; Pohner, I.; Muller, W.; Panecka-Hofman, J.; Wade, R.C.; Fenske, M.; Clos, J.; Alunda, J.M.; Corral, M.J.; Uliassi, E.; Bolognesi, M.L.; Linciano, P.; Quotadamo, A.; Ferrari, S.; Santucci, M.; Borsari, C.; Costi, M.P.; Gul, S.
Journal Article
2019Achievement Of CDAPSA Low Disease Activity Or Remission Is Associated With Control Of Articular And Extra-Articular Manifestations Of Active Psoriatic Arthritis In Subjects Treated With Apremilast
Coates, L.C.; Mease, P.J.; Behrens, F.; Orbai, A.M.; Ogdie, A.; Brunori, M.; Teng, L.; Guerette, B.; Smolen, J.S.
Abstract
2019Activated Cross-linked Agarose for the Rapid Development of Affinity Chromatography Resins - Antibody Capture as a Case Study
Knödler, M.; Rühl, C.; Opdensteinen, P.; Buyel, J.F.
Journal Article
2019Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound
Ehrnhoefer, D.E.; Skotte, N.H.; Reinshagen, J.; Qiu, X.; Windshügel, B.; Jaishankar, P.; Ladha, S.; Petina, O.; Khankischpur, M.; Nguyen, Y.T.N.; Caron, N.S.; Razeto, A.; Meyer zu Rheda, M.; Deng, Y.; Huynh, K.T.; Wittig, I.; Gribbon, P.; Renslo, A.R.; Geffken, D.; Gul, S.; Hayden, M.R.
Journal Article
2019ADAM15 in Apoptosis Resistance of Synovial Fibroblasts
Janczi, T.; Böhm, B.B.; Fehrl, Y.; DeGiacomo, P.; Kinne, R.W.; Burkhardt, H.
Journal Article
2019Addition or removal of concomitant methotrexate alters adalimumab effectiveness in rheumatoid arthritis but not psoriatic arthritis
Behrens, F.; Koehm, M.; Schwaneck, E.C.; Schmalzing, M.; Wittig, B.M.; Gnann, H.; Greger, G.; Tony, H.P.; Burkhardt, H.
Journal Article
2019Advanced in silico modeling explains pharmacokinetics and biodistribution of temoporfin nanocrystals in humans
Jablonka, L.; Ashtikar, M.; Gao, G.; Jung, F.; Thurn, M.; Preuß, A.; Scheglmann, D.; Albrecht, V.; Röder, B.; Wacker, M.G.
Journal Article
2019Aeration and Shear Stress Are Critical Process Parameters for the Production of Oncolytic Measles Virus
Grein, T.A.; Loewe, D.; Dieken, H.; Weidner, T.; Salzig, D.; Czermak, P.
Journal Article
2019Aktuelle Therapie der Psoriasisarthritis
Köhm, M.; Behrens, F.
Journal Article
2019Alternativen zum Wachstum
Schäfers, Christoph; Bette, Kristina; Herrmann, Florian; Nawroth, Georg
Book Article
2019Analyses of association of psoriatic arthritis and psoriasis vulgaris with functional NCF1 variants
Löhr, S.; Ekici, A.B.; Uebe, S.; Büttner, C.; Köhm, M.; Behrens, F.; Böhm, B.; Sticherling, M.; Schett, G.; Simon, D.; Mössner, R.; Nimeh, A.; Oji, V.; Assmann, G.; Rech, J.; Holmdahl, R.; Burkhardt, H.; Reis, A.; Hüffmeier, U.
Journal Article
2019Antibacterial and antifungal activity of defensins from the Australian paralysis tick, Ixodes holocyclus
Cabezas-Cruz, A.; Tonk, M.; Bleackley, M.R.; Valdes, J.J.; Barrero, R.A.; Hernández-Jarguín, A.; Moutailler, S.; Vilcinskas, A.; Richard-Forget, F.; Anderson, M.A.; Rodriguez-Valle, M.
Journal Article
2019Antibiotic-producing beneficial bacteria in the gut of the burying beetle nicrophorus vespilloides
Heise, P.; Liu, Y.; Degenkolb, T.; Vogel, H.; Schäberle, T.F.; Vilcinskas, A.
Journal Article
2019The Antisteatotic and Hypolipidemic Effect of Insect Meal in Obese Zucker Rats is Accompanied by Profound Changes in Hepatic Phospholipid and 1-Carbon Metabolism
Meyer, S.; Gessner, D.K.; Wen, G.; Most, E.; Liebisch, G.; Zorn, H.; Ringseis, R.; Eder, K.
Journal Article
2019Application of a Refined Developability Classification System
Rosenberger, J.; Butler, J.; Muenster, U.; Dressman, J.
Journal Article
2019Application of adverse outcome pathways and quantitative in vitro-in vivo extrapolation (QIVIVE) modelling for risk assessment based on in vitro data
Mally, A.; Birk, B.; Fiore, S. di; Ellinger, B.; Jarzina, S.; Reiser, P.; Taverne, F.; Kramer, N.
Abstract
2019Application of the relationship between pharmacokinetics and pharmacodynamics in drug development and therapeutic equivalence: a PEARRL review
Loisios‐Konstantinidis, I.; Paraiso, R.L.M.; Fotaki, N.; McAllister, M.; Cristofoletti, R.; Dressman, J.
Journal Article
2019Association analyses of functional NCF1 variants in psoriatic arthritis and psoriasis vulgaris
Hüffmeier, U.D.; Löhr, S.; Ekici, A.B.; Uebe, S.; Köhm, M.; Behrens, F.; Böhm, B.; Sticherling, M.; Schett, G.; Mössner, R.; Nimeh, A.; Assmann, G.; Rech, J.; Oji, V.; Holmdahl, R.; Burkhardt, H.; Reis, A.
Abstract
2019Bewertung des endokrinen Potenzials von Bisphenol Alternativstoffen in umweltrelevanten Verwendungen. Abschlussbericht
Eilebrecht, Elke; Wenzel, Andrea; Teigeler, Matthias; Windshügel, Björn; Keminer, Oliver; Chachulski, Laura; Kohler, Manfred
Report
2019Beyond leukotriene formation
Häfner, A.-K.; Kahnt, A.S.; Steinhilber, D.
Journal Article
2019Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury
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Abstract
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Abstract
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2019Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie. Jahresbericht 2018
 
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Abstract
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Abstract
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Report
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Abstract
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Abstract
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Report
2019Protection of the groundwater against loads of plant protection products: Validation of the new EU-simulation model FO-CUS PELMO 4 for a reliable prediction of the leaching potential of PPP into groundwater
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Report
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Abstract
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Abstract
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Abstract
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Report
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Dissertation
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Piña, M.; Colas, P.; Cancio, I.; Audic, A.; Bosser, L.; Canario, A.; Gribbon, P.; Johnston, I.A.; Kervella, A.E.; Kooistra, W.H.C.F.; Merciecca, M.; Magoulas, A.; Nardello, I.; Smith, D.; Pade, N.; Robinson, D.; Schön, A.; Schultz, F.; Kloareg, B.
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2018Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie. Jahresbericht 2017/2018
 
Annual Report
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Wasmuth, C.
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Gresch, G.
Dissertation
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Gupta, D.K.; Rühl, M.; Mishra, B.; Kleofas, V.; Hofrichter, M.; Herzog, R.; Pecyna, M.J.; Sharma, R.; Kellner, H.; Hennicke, F.; Thines, M.
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Journal Article
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Journal Article
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Book Article
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Journal Article
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Fei, Y.
Dissertation
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Stoessel, D.; Stellmann, J.-P.; Willing, A.; Behrens, B.; Rosenkranz, S.C.; Hodecker, S.C.; Stürner, K.H.; Reinhardt, S.; Fleischer, S.; Deuschle, C.; Maetzler, W.; Berg, D.; Heesen, C.; Walther, D.; Schauer, N.; Friese, M.A.; Pless, O.
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Journal Article
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Nothnagel, L.; Wacker, M.G.
Journal Article
2018Mikro-und Nanoarzneiformen in Formulierung und Qualitätskontrolle. Teil 2
Nothnagel, L.; Wacker, M.G.
Journal Article
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Häcker, I.; Schetelig , M.F.
Journal Article
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Friese, Manuel; Pleß, Ole; Schauer, Nicolas; Stoessel, Daniel
Patent
2018A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages
Snodgrass, R.G.; Zezina, E.; Namgaladze, D.; Gupta, S.; Angioni, C.; Geisslinger, G.; Lütjohann, D.; Brüne, B.
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Hochrainer, D.
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Lim, S.S.Y.; Chua, K.H.; Nölke, G.; Spiegel, H.; Goh, W.L.; Chow, S.C.; Kee, B.P.; Fischer, R.; Schillberg, S.; Othman, R.Y.
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: Segner, Helmut; Schlechtriem, Christian
Dissertation
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Patent
2018The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2–mediated neuropathic pain induced by mechanical nerve damage
Treutlein, E.-M.; Kern, K.; Weigert, A.; Tarighi, N.; Schuh, C.-D.; Nüsing, R.M.; Schreiber, Y.; Ferreirós, N.; Brüne, B.; Geisslinger, G.; Pierre, S.; Scholich, K.
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Journal Article
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Journal Article
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Presentation
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Journal Article
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Journal Article
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Journal Article
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Journal Article
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Journal Article
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Ockleford, Colin; Adriaanse, Paulien; Berny, Philippe; Brock, Theodorus; Duquesne, Sabine; Grilli, Sandro; Hernandez-Jerez, Antonio F.; Hougaard Bennekou, Susanne; Klein, Michael; et. al.
Journal Article
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Ockleford, Colin; Adriaanse, Paulien; Berny, Philippe; Brock, Theodorus; Duquesne, Sabine; Grilli, Sandro; Hernandez-Jerez, Antonio F.; Hougaard Bennekou, Susanne; Klein, Michael; Kuhl, Thomas; Laskowski, Ryszard; Machera, Kyriaki; Pelkonen, Olavi; Pieper, Silvia; Stemmer, Michael; Sundh, Ingvar; Teodorovic, Ivana; Tiktak, Aaldrik; Topping, Chris J.; Wolterink, Gerrit; Craig, Peter; Jong, Frank de; Manachini, Barbara; Sousa, Paulo; Swarowsky, Klaus; Auteri, Domenica; Arena, Maria; Smith, Rob
Journal Article
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Kampe, Sebastian; Kägi, Ralf; Schlich, Karsten; Wasmuth, Claus; Hollert, Henner; Schlechtriem, Christian
Journal Article
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Kühr, Sebastian; Schneider, Stefanie; Meisterjahn, Boris; Schlich, Karsten; Hund-Rinke, Kerstin; Schlechtriem, Christian
Journal Article
2018Simultaneous and Independent Dual Site-Specific Self-Labeling of Recombinant Antibodies
Wollschläger, C.; Meinhold-Heerlein, I.; Cong, X.; Bräutigam, K.; Fiore, S. Di; Zeppernick, F.; Klockenbring, T.; Stickeler, E.; Barth, S.; Hussain, A.F.
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Toewe, A.; Balas, L.; Durand, T.; Geisslinger, G.; Ferreirós, N.
Journal Article
2018Simultaneous response in several domains in patients with psoriatic disease treated with etanercept as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs
Behrens, F.; Meier, L.; Prinz, J.C.; Jobst, J.; Lippe, R.; Löschmann, P.-A.; Lorenz, H.-M.
Journal Article
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Zitzmann, J.; Schreiber, C.; Eichmann, J.; Bilz, R.O.; Salzig, D.; Weidner, T.; Czermak, P.
Journal Article
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Pachernegg, Svenja; Eilebrecht, Sebastian; Eilebrecht, Elke; Schöneborn, Hendrik; Neumann, Sebastian; Benecke, Arndt G.; Hollmann, Michael
Journal Article
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Laibach, N.; Schmidl, S.; Müller, B.; Bergmann, M.; Prüfer, D.; Schulze Gronover, C.
Journal Article
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Sehnert, B.; Burkhardt, H.; Finzel, S.; Dübel, S.; Voll, R.E.
Journal Article
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Nasfi, Z.; Busch, H.; Kehraus, S.; Linares-Otoya, L.; König, G.M.; Schäberle, T.F.; Bachoual, R.
Journal Article
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Eresch, J.; Stumpf, M.; Koch, A.; Vutukuri, R.; Ferreiros, N.; Schreiber, Y.; Schröder, K.; Devraj, K.; Popp, R.; Huwiler, A.; Hattenbach, L.-O.; Pfeilschifter, J.; Pfeilschifter, W.
Journal Article
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Fettel, J.; Kühn, B.; Guillen, N.A.; Sürün, D.; Peters, M.; Bauer, R.; Angioni, C.; Geisslinger, G.; Schnütgen, F.; Meyer zu Heringdorf, D.; Werz, O.; Meybohm, P.; Zacharowski, K.; Steinhilber, D.; Roos, J.; Maier, T.J.
Journal Article
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Fliedner, Annette; Müller, Martin
Report
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Dauth, S.; Köhm, M.; Rossmanith, T.; Herrmann, E.; Lehn, A.; Burkhardt, H.; Behrens, F.
Journal Article
2018The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1
Knecht, K.M.; Buzovetsky, O.; Schneider, C.; Thomas, D.; Srikanth, V.; Kaderali, L.; Tofoleanu, F.; Reiss, K.; Ferreirós, N.; Geisslinger, G.; Batista, V.S.; Ji, X.; Cinatl, J.; Keppler, O.T.; Xiong, Y.
Journal Article
2018Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation
Spry, C.; Sewell, A.L.; Hering, Y.; Villa, M.V.J.; Weber, J.; Hobson, S.J.; Harnor, S.J.; Gul, S.; Marquez, R.; Salib, K.J.
Journal Article
2018Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders
Thalman, C.; Horta, G.; Qiao, L.; Endle, H.; Tegeder, I.; Cheng, H.; Laube, G.; Sigurdsson, T.; Hauser, M.J.; Tenzer, S.; Distler, U.; Aoki, J.; Morris, A.J.; Geisslinger, G.; Röper, J.; Kirischuk, S.; Luhmann, H.J.; Radyushkin, K.; Nitsch, R.; Vogt, J.
Journal Article
2018T Cell Phenotype and T Cell Receptor Repertoire in Patients with Major Depressive Disorder
Patas, K.; Willing, A.; Demiralay, C.; Engler, J.B.; Lupu, A.; Ramien, C.; Schäfer, T.; Gach, C.; Stumm, L.; Chan, K.; Vignali, M.; Arck, P.C.; Friese, M.A.; Pless, O.; Wiedemann, K.; Agorastos, A.; Gold, S.M.
Journal Article
2018Taraxacum brevicorniculatum rubber elongation factor TbREF associates with lipid droplets and affects lipid turn-over in yeast
Bröker, J.N.; Laibach, N.; Müller, B.; Prüfer, D.; Schulze Gronover, C.
Journal Article
2018Therapeutics discovery: From bench to first in-human trials
Al-Hujaily, E.M.; Khatlani, T.; Alehaideb, Z.; Ali, R.; Almuzaini, B.; Alrfaei, B.M.; Iqbal, J.; Islam, I.; Malik, S.; Marwani, B.A.; Massadeh, S.; Muzaini, B.; Nehdi, A.; Alsomaie, B.; Debasi, B.; Bushnak, I.; Noibi, S.; Hussain, S.; Wajid, W.A.; Armand, J.-P.; Gul, S.; Oyarzabal, J.; Rais, R.; Bountra, C.; Alaskar, A.; Al Knawy, B.; Boudjelal, M.
Journal Article
2018Three-Dimensional Bioreactor Technologies for the Cocultivation of Human Mesenchymal Stem/Stromal Cells and Beta Cells
Petry, F.; Weidner, T.; Czermak, P.; Salzig, D.
Journal Article
2018Total Synthesis and Structural Revision of the Antibiotic Tetrapeptide GE81112A
Jürjens, G.; Schuler, S.M.M.; Kurz, M.; Petit, S.; Couturier, C.; Jeannot, F.; Nguyen, F.; Wende, R.C.; Hammann, P.E.; Wilson, D.N.; Bacqué, E.; Pöverlein, C.; Bauer, A.
Journal Article
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Sala, A.; Proschak, E.; Steinhilber, D.; Rovati, G.E.
Journal Article
2018UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells
Wegner, M.-S.; Schömel, N.; Gruber, L.; Örtel, S.B.; Kjellberg, M.A.; Mattjus, P.; Kurz, J.; Trautmann, S.; Peng, B.; Wegner, M.; Kaulich, M.; Ahrends, R.; Geisslinger, G.; Grösch, S.
Journal Article
2018The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1)
Wegner, M.-S.; Gruber, L.; Mattjus, P.; Geisslinger, G.; Grösch, S.
Journal Article
2018A unique fungal strain collection from Vietnam characterized for high performance degraders of bioecological important biopolymers and lipids
Brandt, S.C.; Ellinger, B.; Nguyen, T. van; Thi, Q.D.; Nguyen, G. van; Baschien, C.; Yurkov, A.; Hahnke, R.L.; Schäfer, W.; Gand, M.
Journal Article
2018Untersuchungen zur Regulation der Leukotrien-Biosynthese durch Sphingosin-1-Phosphat
Fettel, J.
Dissertation
2018Upregulating the mevalonate pathway and repressing sterol synthesis in Saccharomyces cerevisiae enhances the production of triterpenes
Bröker, J.N.; Müller, B.; Deenen, N. van; Prüfer, D.; Schulze Gronover, C.
Journal Article
2018Uptake and effects of cerium(III) and cerium oxide nanoparticles to Chlamydomonas reinhardtii
Kosak, Lena A.; Brandt, Tanja; Sigg, Laura; Behra, Renata
Journal Article
2018Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro
Heitel, P.; Gellrich, L.; Heering, J.; Goebel, T.; Kahnt, A.; Proschak, E.; Schubert-Zsilavecz, M.; Merk, D.
Journal Article
2018Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro
Heitel, P.; Gellrich, L.; Heering, J.; Goebel, T.; Kahnt, A.; Proschak, E.; Schubert-Zsilavecz, M.; Merk, D.
Journal Article
2018Use of Computational Functional Genomics in Drug Discovery and Repurposing for Analgesic Indications
Lötsch, J.; Kringel, D.
Journal Article
2018When facing multiple enemies: the impact of host development time and exposure to multiple parasites in shaping coevolutionary adaptations in host and parasites
Biswas, T.
Dissertation
2017Activated platelets induce an anti-inflammatory response of monocytes/macrophages through cross-regulation of PGE2 and cytokines
Linke, B.; Schreiber, Y.; Picard-Willems, B.; Slattery, P.; Nüsing, R.M.; Harder, S.; Geisslinger, G.; Scholich, K.
Journal Article
2017AMP-activated kinase and the endogenous endocannabinoid system might contribute to antinociceptive effects of prolonged moderate caloric restriction in mice
King-Himmelreich, T.S.; Möser, C.V.; Wolters, M.C.; Schmetzer, J.; Möller, M.; Schreiber, Y.
Journal Article
2017AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids
King-Himmelreich, T.S.; Möser, C.V.; Wolters, M.C.; Schmetzer, J.; Schreiber, Y.; Ferreirós, N.; Russe, O.Q.; Geisslinger, G.; Niederberger, E.
Journal Article
2017Anaerobic Membrane Bioreactor for Continuous Lactic Acid Fermentation
Fan, R.; Ebrahimi, M.; Czermak, P.
Journal Article
2017Analysis of virus susceptibility in the invasive insect pest Drosophila suzukii
Kwang-Zin, L.; Vilcinskas, A.
Journal Article
2017Animal component-free Agrobacterium tumefaciens cultivation media for better GMP-compliance increases biomass yield and pharmaceutical protein expression in Nicotiana benthamiana
Houdelet, M.; Galinski, A.; Holland, T.; Wenzel, K.; Schillberg, S.; Buyel, J.F.
Journal Article
2017Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage
Ge, C.; Tong, D.; Liang, B.; Lönnblom, E.; Schneider, N.; Hagert, C.; Viljanen, J.; Ayoglu, B.; Stawikowska, R.; Nilsson, P.; Fields, G.B.; Skogh, T.; Kastbom, A.; Kihlberg, J.; Burkhardt, H.; Dobritzsch, D.; Holmdahl, R.
Journal Article
2017Anti-GPVI Fab SAR264565 effectively blocks GPVI function in ex vivo human platelets under arterial shear in a perfusion chamber
Florian, P.; Wonerow, P.; Harder, S.; Kuczka, K.; Dubar, M.; Graff, J.
Journal Article
2017Antibodies from plants for bionanomaterials
Edgue, G.; Twyman, R.M.; Beiss, V.; Fischer, R.; Sack, M.
Journal Article
2017Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis
Netzer, C.; Knape, T.; Kuchler, L.; Weigert, A.; Zacharowski, K.; Pfeilschifter, W.; Sempowski, G.; Parnham, M.J.; Brüne, B.; Knethen, A. von
Journal Article
2017Baculovirus-induced recombinant protein expression in human mesenchymal stromal stem cells: A promoter study
Sprick, G.; Weidner, T.; Salzig, D.; Czermak, P.
Journal Article
2017BCX7353, a once-daily oral kallikrein inhibitor, is effective and safe in the prophylaxis of acute attacks in patients with hereditary angioedema: Attack-level analysis of the APeX-1 study
Aygören, E.; Bygum, A.; Steiner, U.; Magerl, M.; Panovska, V.G.; Farkas, H.; Huissoon, A.; Graff, J.; Lleonart, R.; Rae, W.; Aberer, W.; Longhurst, H.; Smith, W.; Zanichelli, A.; Cancian, M.; Guilarte, M.; Triggiani, M.; Gompels, M.; Fang, L.; Cornpropst, M.; Clemons, D.; Collis, P.; Dobo, S.; Sheridan, W.P.; Maurer, M.; Cicardi, M.
Abstract
2017Behavioral and immunological features promoting the invasive performance of the harlequin ladybird Harmonia axyridis
Verheggen, F.J.; Vogel, H.; Vilcinskas, A.
Journal Article
2017Bewertung der Grundwasserbelastung durch Wirkstoffe - was wollen wir schützen?
Schäfers, Christoph
Conference Paper
2017Bewertung des Eintrags von Pflanzenschutzmitteln in Oberflächengewässer - Runoff, Erosion und Drainage
Bach, Martin; Guerniche, Djamal; Thomas, Kai; Trapp, Matthias; Kubiak, Roland; Hommen, Udo; Klein, Michael; Reichenberger, Stefan; Pires, José; Preuß, Thomas
Report
2017Beyond Immune Cell Migration
Olesch, C.; Ringel, C.; Brüne, B.; Weigert, A.
Journal Article
2017Bioactivity of natural and engineered antimicrobial peptides from venom of the scorpions urodacus yaschenkoi and U. Manicatus
Luna-Ramirez, K.; Tonk, M.; Rahnamaeian, M.; Vilcinskas, A.
Journal Article
2017Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice
Schmitz, K.; Tegeder, I.
Journal Article
2017Biophysical characterization of E. coli TolC interaction with the known blocker hexaamminecobalt
Gilardi, A.; Bhamidimarri, S.P.; Brönstrup, M.; Bilitewski, U.; Marreddy, R.K.R.; Pos, K.M.; Benier, L.; Gribbon, P.; Winterhalter, M.; Windshügel, B.
Journal Article
2017Blanchieren vereinfacht die Reinigung rekombinanter Proteine aus Pflanzen
Buyel, J.F.
Journal Article
2017Building early-larval sexing systems for genetic control of the Australian sheep blow fly Lucilia cuprina using two constitutive promoters
Yan, Y.; Linger, R.J.; Scott, M.J.
Journal Article
2017Burying beetles regulate the microbiome of carcasses and use it to transmit a core microbiota to their offspring
Shukla, S.P.; Vogel, H.; Heckel, D.G.; Vilcinskas, A.; Kaltenpoth, M.
Journal Article
2017Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE
Hosseini, S.K.; Kolterer, S.; Steiner, M.; Manstein, V. von; Gerlach, K.; Trojan, J.; Waidmann, O.; Zeuzem, S.; Schulze, J.O.; Hahn, S.; Steinhilber, D.; Gatterdam, V.; Tampé, R.; Biondi, R.M.; Proschak, E.; Zörnig, M.
Journal Article
2017Can solid-phase microextraction replace solvent extraction for water analysis in fish bioconcentration studies with highly hydrophobic organic chemicals?
Böhm, L.; Düring, R.-A.; Bruckert, H.-J.; Schlechtriem, C.
Journal Article
2017Cancer cell and macrophage cross-talk in the tumor microenvironment
Dehne, N.; Mora, J.; Namgaladze, D.; Weigert, A.; Brüne, B.
Journal Article
2017Cannabinoid antagonist SLV326 induces convulsive seizures and changes in the interictal EEG in rats
Perescis, M.F.J.; Bruin, N. de; Heijink, L.; Kruse, C.; Vinogradova, L.; Lüttjohann, A.; Luijtelaar, G. van; Rijn, C.M. van
Journal Article
2017CarbORev‐5901: The First Carborane‐Based Inhibitor of the 5‐Lipoxygenase Pathway
Kuhnert, R.; Sárosi, M.-B.; George, S.; Lönnecke, P.; Hofmann, B.; Steinhilber, D.; Murganic, B.; Mijatovic, S.; Maksimovic‐Ivanic, D.; Hey‐Hawkins, E.
Journal Article
2017CD200 selectively upregulates prostaglandin E2 and D2 synthesis in LPS-treated bone marrow-derived macrophages
Kern, K.; Pierre, S.; Schreiber, Y.; Angioni, C.; Thomas, D.; Ferreirós, N.; Geisslinger, G.; Scholich, K.
Journal Article
2017Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice
Oertel, S.; Scholich, K.; Weigert, A.; Thomas, D.; Schmetzer, J.; Trautmann, S.; Wegner, M.S.; Radeke, H.H.; Filmann, N.; Brüne, B.; Geisslinger, G.; Tegeder, I.; Grösch, S.
Journal Article
2017Cetuximab Resistance in Head and Neck Cancer Is Mediated by EGFR-K-521 Polymorphism
Braig, F.; Kriegs, M.; Voigtlaender, M.; Habel, B.; Grob, T.; Biskup, K.; Blanchard, V.; Sack, M.; Thalhammer, A.; Ben Batalla, I.; Braren, I.; Laban, S.; Danielczyk, A.; Goletz, S.; Jakubowicz, E.; Märkl, B.; Trepel, M.; Knecht, R.; Riecken, K.; Fehse, B.; Loges, S.; Bokemeyer, C.; Binder, M.
Journal Article
2017Challenges in assigning endocrine-specific modes of action: Recommendations for researchers and regulators
Mihaich, Ellen M.; Schäfers, Christoph; Dreier, David A.; Hecker, Markus; Ortego, Lisa; Kawashima, Yukio; Dang, Zhi-Chao; Solomon, Keith
Journal Article
2017Challenges in the drug release testing of next-generation nanomedicines - what do we know?
Wacker, M.G.
Journal Article, Conference Paper
2017Characteristics of Genome Editing Mutations in Cereal Crops
Zhu, C.; Bortesi, L.; Baysal, C.; Twyman, R.M.; Fischer, R.; Capell, T.; Schillberg, S.; Christou, P.
Journal Article
2017Characterization and cellular localization of human 5-lipoxygenase and its protein isoforms 5-LOΔ13, 5-LOΔ4 and 5-LOp12
Ball, A.-K.; Beilstein, K.; Wittmann, S.; Sürün, D.; Saul, M.J.; Schnütgen, F.; Flamand, N.; Capelo, R.; Kahnt, A.S.; Frey, H.; Schaefer, L.; Marschalek, R.; Häfner, A.-K.; Steinhilber, D.
Journal Article
2017Characterization of novel insect cytochrome P450-fusion enzymes
Talmann, L.
Dissertation
2017Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles
Kretschmer, S.B.M.; Woltersdorf, S.; Vogt, D.; Lillich, F.F.; Rühl, M.; Karas, M.; Maucher, I.V.; Roos, J.; Häfner, A.-K.; Kaiser, A.; Wurglics, M.; Schubert-Zsilavecz, M.; Angioni, C.; Geisslinger, G.; Stark, H.; Steinhilber, D.; Hofmann, B.
Journal Article
2017Charakterisierung der thymalen T-Zell-Reifung und -Auswanderung während der Sepsis mittels TRECs
Netzer, C.
Dissertation
2017Charakterisierung und Evaluierung neuartiger Antikörperfragment-Immunkonjugate basierend auf der SNAP-Tag Technologie
Woitok, M.
Dissertation
2017Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity
Pisa, F. di; Landi, G.; Iacono, L. dello; Pozzi, C.; Borsari, C.; Ferrari, S.; Santucci, M.; Santarem, N.; Cordeiro-da-Silva, A.; Moraes, C.B.; Alcantara, L.M.; Fontana, V.; Freitas, L.H.; Gul, S.; Kuzikov, M.; Behrens, B.; Pöhner, I.; Wade, R.C.; Costi, M.P.; Mangani, S.
Journal Article
2017Classification of baseline toxicants for QSAR predictions to replace fish acute toxicity studies
Nendza, Monika; Müller, Martin; Wenzel, Andrea
Journal Article
2017Cleavage of SNAP‐25 ameliorates cancer pain in a mouse model of melanoma
Olbrich, K.; Costard, L.; Möser, C.V.; Syhr, K.M.J.; King‐Himmelreich, T.S.; Wolters, M.C.; Schmidtko, A.; Geisslinger, G.; Niederberger, E.
Journal Article
2017Combination of two epitope identification techniques enables the rational design of soy allergen Gly m 4 mutants
Havenith, Heide; Kern, Karolin; Rautenberger, Paul; Spiegel, Holger; Szardenings, Michael; Ueberham, Elke; Lehmann, Jörg; Buntru, Matthias; Vogel, Simon; Treudler, Regina; Fischer, Rainer; Schillberg, Stefan
Journal Article
2017Combined 15N-Labeling and TandemMOAC Quantifies Phosphorylation of MAP Kinase Substrates Downstream of MKK7 in Arabidopsis
Huck, N.V.; Leissing, F.; Majovsky, P.; Buntru, M.; Aretz, C.; Flecken, M.; Müller, J.P.J.; Vogel, S.; Schillberg, S.; Hoehenwarter, W.; Conrath, U.; Beckers, G.J.M.
Journal Article
2017Comparative Analysis of Achievement of Individual Important Response Measured By DAS28dcrit in a Randomized Head-to-Head Trial of Tocilizumab Vs. Adalimumab in Active Rheumatoid Arthritis
Koehm, M.; Hofmann, M.; Lüthje, R.; McIntosh, M.; Abraham, V.; Gabay, C.; Kavanaugh, A.; Burkhardt, H.; Behrens, F.
Abstract
2017Comparison of a mouse and a novel human scFv-SNAP-auristatin F drug conjugate with potent activity against EGFR-overexpressing human solid tumor cells
Woitok, M.; Klose, D.; Fiore, S. di; Richter, W.; Stein, C.; Gresch, G.; Grieger, E.; Barth, S.; Fischer, R.; Kolberg, K.; Niesen, J.
Journal Article
2017Comparison of in-vitro and ex-vivo wound healing assays for the investigation of diabetic wound healing and demonstration of a beneficial effect of a triterpene extract
Ueck, C.; Volksdorf, T.; Houdek, P.; Vidal-Y-Sy, S.; Sehner, S.; Ellinger, B.; Lobmann, R.; Larena-Avellaneda, A.; Reinshagen, K.; Ridderbusch, I.; Kohrmeyer, K.; Moll, I.; Daniels, R.; Werner, P.; Merfort, I.; Brandner, J.M.
Journal Article
2017The components of shear stress affecting insect cells used with the baculovirus expression vector system
Weidner, T.; Druzinec, D.; Mühlmann, M.; Buchholz, R.; Czermak, P.
Journal Article
2017Concentration dependent transcriptome responses of zebrafish embryos after exposure to cadmium, cobalt and copper
Sonnack, Laura; Klawonn, Thorsten; Kriehuber, Ralf; Hollert, Henner; Schäfers, Christoph; Fenske, Martina
Journal Article
2017Contained molecular farming using plant cell and tissue cultures
Schillberg, S.; Raven, Nicole; Fischer, R.; Twyman, R.M.; Schiermeyer, A.
Book Article
2017Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity
Uliassi, E.; Fiorani, G.; Krauth-Siegel, R.L.; Bergamini, C.; Fato, R.; Bianchini, G.; Carlos Menéndez, J.; Molina, M.T.; López-Montero, E.; Falchi, F.; Cavalli, A.; Gul, S.; Kuzikov, M.; Ellinger, B.; Witt, G.; Moraes, C.B.; Freitas-Junior, L.H.; Borsari, C.; Costi, M.P.; Bolognesi, M.L.
Journal Article
2017Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity
Uliassi, E.; Fiorani, G.; Krauth-Siegel, R.L.; Bergamini, C.; Fato, R.; Bianchini, G.; Carlos Menéndez, J.; Molina, M.T.; López-Montero, E.; Falchi, F.; Cavalli, A.; Gul, S.; Kuzikov, M.; Ellinger, B.; Witt, G.; Moraes, C.B.; Freitas-Junior, L.H.; Borsari, C.; Costi, M.P.; Bolognesi, M.L.
Journal Article