Fraunhofer-Gesellschaft

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Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2014Etablierung eines Modellsystems mit Aerosolen zur Charakterisierung von Expositionssystemen für die Untersuchung inhalierbarer Substanzen in vitro
Arndt, Hendrik
: Walker, Gottfried (Erstprüfer); Knebel, Jan W. (Zweitprüfer)
Bachelor Thesis
2014Evaluation of the deposition, translocation and pathological response of brake dust with and without added chrysotile in comparison to crocidolite asbestos following short-term inhalation: Interim results
Bernstein, David M.; Rogers, Rick; Sepulveda, Rosalina; Kunzendorf, Peter; Bellmann, Bernd; Ernst, Heinrich; Phillips, James I.
Journal Article
2014Inhalation toxicity of nanoparticle-based aerosols
Gessner, Isabel
: Mathur, Sanjay (Betreuer); Knebel, Jan W. (Betreuer); Dasenbrock, Clemens (Zweitprüfer)
Master Thesis
2012A pilot study on the refinement of acute inhalation toxicity studies
Fischer, M.; Koch, W.; Windt, H.; Dasenbrock, C.
Journal Article
2011Prävalidierungsstudie zur Prüfung der toxischen Wirkung von inhalativ wirksamen Stoffen (Gase)
Knebel, Jan; Ritter, Detlef; Berger-Preiß, Edith; Kock, Heiko; Liebsch, Manfred; Smirnova, Lena; Pirow, Ralph; Linsel, Gunter; Bauer, Mario; Graebsch, Carolin
Study
2009Nano- and microscaled titanium dioxide: Comparative study on the inflammatory and genotoxic effects after a 3-week inhalation in rats
Creutzenberg, O.; Pohlmann, G.; Hansen, T.; Rittinghausen, S.; Taugner, F.; Ziemann, C.
Conference Paper, Journal Article
2008Inhalation juvenile rat studies can be performed as early as at day 4 post partum
Lewin, G.; Fuhst, R.; Berger-Preiß, E.; Pohlmann, G.; Buschmann, J.
Journal Article
2006Collection, validation and generation of bitumen fumes for inhalation studies in rats. Pt.1: Workplace samples and validation criteria
Preiß, A.; Koch, W.; Kock, H.; Raabe, M.; Pohlmann, G.
Journal Article
2006Collection, validation and generation of bitumen fumes for inhalation studies in rats. Pt.2: Collection of bitumen fumes from storage tanks
Pohlmann, G.; Preiß, A.; Levsen, K.; Raabe, M.; Koch, W.
Journal Article
2005Metabolism of verapamil in cultures of rat alveolar epithelial cells and pharmacokinetics after administration by intravenous and inhalation routes
Borlak, J.; Blickwede, M.; Hansen, T.; Koch, W.; Walles, M.; Levsen, K.
Journal Article
2005Methylene diphenyl diisocyanate (MDI) aerosol and long-term pulmonary lesions in Wistar rats
Ernst, H.; Kittel, B.; Rittinghausen, S.
Book Article
2004Collection, validation and generation of bitumen fumes for inhalation studies in rats
Preiß, A.; Pohlmann, G.
Report
2003Calibration study on subchronic inhalation toxicity of man-made vitreous fibers in rats
Bellmann, B.; Muhle, H.; Creutzenberg, O.; Ernst, H.; Müller, M.; Bernstein, D.M.; Riego Sintes, J.M.
Journal Article
2002Crucial issues in inhalation research - mechanistic, clinical and epidemiologic
: Heinrich, U.; Mohr, U.
Conference Proceedings
2002A method for the in vitro exposure of human cells to environmental and complex gaseous mixtures
Aufderheide, M.; Knebel, J.W.; Ritter, D.
Journal Article
2002Subchronic studies on man-made vitreous fibres. Kinetics of inhaled particles
Bellmann, B.; Muhle, H.; Ernst, H.; Pohlmann, G.; Sébastien, P.; Brown, R.
Journal Article
2002Subchronic studies on man-made vitreous fibres. Toxicity results
Brown, R.; Bellmann, B.; Muhle, H.; Ernst, H.; Pohlmann, G.; Sébastien, P.
Journal Article
2001Bioverfügbarkeit von Azopigmenten nach Aufnahme über die Atemwege
Bartsch, W.; Berger-Preiß, E.; Dasenbrock, C.; Ernst, H.
Book
2001Chronic pulmonary effects of respirable methylene diphenyl diisocyanate (MDI) aerosol in rats
Feron, V.J.; Kittel, B.; Kuper, C.F.; Ernst, H.; Rittinghausen, S.; Muhle, H.; Koch, W.; Gamer, A.; Mallett, A.K.; Hoffmann, H.D.
Journal Article
2001Cross-fostering inhalation toxicity study with hcfc-123 in lactating sprague-dawley rats
Buschmann, J.; Bartsch, W.; Dasenbrock, C.; Fuhst, R.; Pohlmann, G.; Preiß, A.; Berger-Preiß, E.
Journal Article
2001Effects of nonfibrous particles on ceramic fiber (RCF1) toxicity in rats
Bellman, B.; Muhle, H.; Creutzenberg, O.; Ernst, H.; Brown, R.C.; Sebastien, P.
Journal Article
2001Inhalation studies with the Göttingen minipig
Koch, W.; Windt, H.; Walles, M.; Borlak, J.; Clausing, P.
Journal Article
2001Sammlung von Kondensat aus Bitumendampf und Erzeugung von Atmosphären zur tierexperimentellen Inhalation
Pohlmann, G.; Koch, W.; Levsen, K.; Preiß, A.; Fuhst, R.; Muhle, H.; Heinrich, U.
Journal Article
2001Untersuchungen zu möglichen kanzerogenen Effekten von Dämpfen und Aerosolen aus Bitumen nach inhalativer Aufnahme bei Ratten
Fuhst, R.; Levsen, K.; Koch, W.; Muhle, H.; Pohlmann, G.; Preiß, A.; Heinrich, U.
Journal Article
2000Inhalation tolerance study for p-Aramid respirable fiber-shaped particulates (RFP) in rats
Bellmann, B.; Creutzenberg, O.; Dasenbrock, C.; Ernst, H.; Pohlmann, G.; Muhle, H.
Journal Article
2000Investigation of chronic toxic and carcinogenic effects of gasoline engine exhausts deriving from fuel without and with ferrocene additive
Peters, L.; Ernst, H.; Koch, W.; Bartsch, W.; Bellmann, B.; Creutzenberg, O.; Hoymann, H.-G.; Dasenbrock, C.; Heinrich, U.
Journal Article
2000Particle contamination in experimental fiber preparations
Brown, R.; Sebastien, P.; Bellmann, B.; Muhle, H.
Journal Article
2000Production, sinks and mutagenicity of Nitrophenols in the atmosphere
Behnke, W.; Görlitz, B.; Palm, W.-U.; Zetsch, C.
Conference Paper
2000Relationships between acute and chronic effects of air pollution
: Heinrich, U.; Dungworth, D.L.; Brain, J.D.; Driscoll, K.E.; Grafström, R.C.; Harris, C.C.; Mohr, U.
Conference Proceedings
199990-Tage-Inhalationstoxizitätsprüfung von Di-n-butylamin an Wistar(WU)-Ratten
Buschmann, J.; Dasenbrock, C.; Pohlmann, G.; Bartsch, W.; Creutzenberg, O.; Ernst, H.; Schneider, B.
Report
1999Chronic inhalation study in rats exposed to car exhaust originating from fuel with and without ferrocene additive
Peters, L.; Bartsch, W.; Bellmann, B.; Creutzenberg, O.; Dasenbrock, C.; Ernst, H.; Koch, W.; Heinrich, U.
Conference Paper
1998Abschlußbericht zur Studie "Persistenzuntersuchungen von Mineralfasern in vivo und in vitro und Entwicklung von Beurteilungskriterien für die Biobeständigkeit"
Muhle, H.; Sebastian, K.; Bellmann, B.; Böhm, T.
Book Article
1998Die Innenraumsituation nach einer Schädlingsbekämpfungsmaßnahme: Eine Langzeitstudie
Berger-Preiß, E.; Levsen, K.
Journal Article
1998Lung clearance and retention of toner, TiO2, and crystalline silica, utilizing a tracer technique during chronic inhalation exposure in syrian golden hamsters
Creutzenberg, O.; Bellmann, B.; Muhle, H.; Dasenbrock, C.
Journal Article
1998Pulmonary response to toner, TiO2 and crystalline silica upon chronic inhalation exposure in syrian golden hamsters
Muhle, H.; Bellmann, B.; Creutzenberg, O.; Koch, W.; Dasenbrock, C.; Ernst, H.; Mohr, H.
Journal Article
1998Relationships between respiratory disease and exposure to air pollution
: Mohr, U.; Dungworth, D.L.; Brain, J.D.; Driscoll, K.E.; Grafström, R.C.; Harris, C.C.
Conference Proceedings
1997Biopersistance and bronchoalveolar lavage investigations in rats after a subacute inhalation of various man-made mineral fibres
Creutzenberg, O.; Bellmann, B.; Muhle, H.
Journal Article
1997Chronic inhalation toxicity and carcinogenicity of 4,4-methylenediphenyldiisocyanate (MDI) in rats
Hoymann, H.-G.; Buschmann, J.; Ernst, H.; Bartsch, W.; Creutzenberg, O.; Bellmann, B.; Dasenbrock, C.; Koch, W.; Preiß, A.; Heinrich, U.
Journal Article
1997Cystic squamous cell carcinomas in the lungs of Syrian golden hamsters induced by coal oven flue exhaust mixed with pyrolized tar pitch in combination with benzo(a)pyrene
Rittinghausen, S.; Dungworth, D.L.; Dasenbrock, C.; Ernst, H.; Mohr, U.
Journal Article
1997Investigation of the durability of cellulose fibres in rat lungs
Muhle, H.; Ernst, H.; Bellmann, B.
Journal Article
1997Persistenzuntersuchungen von Mineralfasern in vivo und in vitro und Entwicklung von Beurteilungskriterien für die Biobeständigkeit
Bellmann, B.; Böhm, T.; Muhle, H.; Sebastian, K.
Report
1997Pulmonary cystic keratinizing squamous cell lesions of rats after inhalation/instillation of different particles
Rittinghausen, S.; Mohr, U.; Dungworth, D.L.
Journal Article
1997Significance of the biodurability of man-made vitreous fibres to risk assessment
Muhle, H.; Bellmann, B.
Conference Paper
1997The significance of toxicokinetics of solid particles in the rat lung
Muhle, H.
Book Article
1996Comparative response to long-term particle exposure among rats, mice, and hamsters
Heinrich, U.
Journal Article
1996Cystic keratinizing squamous cell carcinomas in the lung of Syrian hamsters induced by a coal oven flue exhaust mixed with pyrolized tar pitch in combination with benzo(a)pyrene
Rittinghausen, S.; Dasenbrock, C.; Mohr, U.
Book Article
1996Embryotoxicity study of monomeric 4,4'-Methylenediphenyl diisocyanate (MDI) aerosol after inhalation exposure in Wistar rats
Buschmann, J.; Koch, W.; Fuhst, R.; Heinrich, U.
Journal Article
1996Tumours of the lower respiratory tract
Mohr, U.; Emura, M.; Dungworth, D.L.; Ernst, H.
Book Article
1995Bronchoalveolar lavage analysis following a subacute inhalation of various man-made mineral fibres in rats
Creutzenberg, O.; Bellmann, B.; Muhle, H.
Journal Article
1995Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel engine exhaust, carbon black, and titanium dioxide
Heinrich, U.; Fuhst, R.; Rittinghausen, S.; Creutzenberg, O.; Bellmann, B.; Koch, W.; Levsen, K.
Journal Article
1995Neoplastic lung lesions in rat after chronic exposure to crystalline silica
Muhle, H.; Kittel, B.; Ernst, H.; Mohr, U.; Mermelstein, R.
Journal Article
1995Particle deposition, retention, and toxicity of poorly soluble dusts
Muhle, H.
Conference Paper
1995Phagocytosis and chemotaxis of rat alveolar macrophages after a combined or separate exposure to ozone and carbon black
Creutzenberg, O.; Bellmann, B.; Klingebiel, R.; Heinrich, U.; Muhle, H.
Conference Paper
1995Toxicity of man-made fibres
Muhle, H.
Conference Paper
1994The carcinogenic effects of carbon black particles and tar-pitch condensation aerosol after inhalation exposure of rats
Heinrich, U.; Dungworth, D.L.; Pott, F.; Peters, L.; Dasenbrock, C.; Levsen, K.; Koch, W.; Creutzenberg, O.; Schulte, A.
Journal Article
1994Carcinogenic effects of solid particles
Heinrich, U.
Conference Paper
1994Comparative investigations of the biodurability of mineral fibers in the rat lung
Muhle, H.; Bellmann, B.; Pott, F.
Conference Paper
1994Effects of single and combined, subchronic exposure to ozone and soot particles on pulmonary surfactant phospholipids and associated protein A and on surface activity in rat lung lavage fluid
Klingebiel, R.; Heinrich, U.; Martin-Carrera, I.; Dettmer, M.; Kühn, A.; Bartsch, W.
Conference Paper
1994Estimation of a lifetime unit lung cancer risk for benzo(a)pyrene (BaP) based on tumor rates in rats exposed to coal tar/pitch condensation aerosol -CTP-
Heinrich, U.; Pott, F.; Roller, M.
Conference Paper, Journal Article
1994Estimation of a lifetime unit lung cancer risk for benzo/a/pyrene based on tumour rates in rats exposed to coal tar/pitch condensation aerosol
Heinrich, U.; Roller, M.; Pott, F.
Journal Article
1994Formation of DNA adducts in rat lung following chronic inhalation of diesel emissions, carbon black and titanium dioxide particles
Gallagher, J.; Heinrich, U.; George, M.; Hendee, L.; Phillips, D.H.; Lewtas, J.
Journal Article
1994Generation of exposure atmospheres
Koch, W.
Conference Paper
1994Goblet cell metaplasia in the peripheral lung tissue of rats after chronic exposure to particles
Kittel, B.; Dungworth, D.L.; Mohr, U.
Conference Paper
1994Histological and ultrastructural alterations of the bronchioloalveolar region in the rat lung after chronic exposure to a pyrolized pitch condensate of carbon black, alone or in combination
Nolte, T.; Thiedemann, K.-U.; Dungworth, D.L.; Ernst, H.; Paulini, I.; Heinrich, U.; Dasenbrock, C.; Peters, L.; Ueberschär, S.; Mohr, U.
Journal Article
1994Induction of squamous cell carcinomas in the mouse lung after long-term inhalation of polycyclic aromatic hydrocarbon-rich exhausts
Schulte, A.; Ernst, H.; Peters, L.; Heinrich, U.
Journal Article
1994Inhalation exposure of rats to tar/pitch condensation aerosol or carbon black alone or in combination with irritant gases
Heinrich, U.; Peters, L.; Creutzenberg, O.; Dasenbrock, C.; Hoymann, H.-G.
Conference Paper
1994Investigation of the biodurability and carcinogenicity of different man-made mineral fibres
Bellmann, B.; Muhle, H.; Pott, F.
Conference Paper
1994Investigation on the durability of man-made vitreous fibers in rat lungs
Bellmann, B.; Muhle, H.; Kamstrup, O.; Draeger, U.F.
Conference Paper
1994Lung tumours in rats after intratracheal instillation of dusts
Pott, F.; Dungworth, D.L.; Heinrich, U.; Muhle, H.; Kamino, K.; Germann, P.-G.; Roller, M.; Rippe, R.M.; Mohr, U.
Conference Paper
1994Pathologic effects of inhaled particles in rat lungs - Associations between inflammatory and neoplastic processes
Dungworth, D.L.; Mohr, U.; Heinrich, U.; Ernst, H.; Kittel, B.
Conference Paper
1994Phagocytosis and chemotaxis of rat alveolar macrophages after a combined or separate exposure to ozone and carbon black
Creutzenberg, O.; Bellmann, B.; Klingebiel, R.; Heinrich, U.; Muhle, H.
Conference Paper
1994Problems of study design. General overview
Muhle, H.
Conference Paper
1994Respirationstrakt
Muhle, H.
Book Article
1994Respiratory toxicology and risk assessment. Proceedings of an International Symposium
: Jenkins, P.G.; Kayser, D.; Muhle, H.; Rosner, G.; Smith, E.M.
Conference Proceedings
1994Significance of biodurability of mineral fibers for their toxicity and carcinogenic potency in the abdominal cavity of rats in comparison with the low sensitivity of inhalation studies
Pott, F.; Roller, M.; Kamino, K.; Bellmann, B.
Journal Article
1994Toxic and carcinogenic effects of solid particles in the respiratory tract
: Mohr, U.; Dungworth, D.L.; Mauderly, J.L.; Oberdörster, G.
Conference Proceedings
1994Toxicokinetics of solid particles in chronic studies using diesel soot, carbon black, toner, titanium dioxide and quartz
Muhle, H.; Bellmann, B.; Creutzenberg, O.
Conference Paper
1993Advances in controlled clinical inhalation studies
: Mohr, U.; Bates, D.V.; Fabel, H.; Utell, M.J.
Conference Proceedings
1993Beurteilung der Kanzerogenität von inhalierbaren Fasern
Pott, Friedrich; Roller, Markus; Althoff, G.H.; Kamino, Kenji; Bellmann, Bernd; Ulm, K.
Conference Paper
1993Carcinogenic effects of solid particles
Heinrich, U.
Conference Paper
1993Effects of single and combined, subchronic exposure to ozone and soot particles on pulmonary surfactant phospholipids, associated protein A and on surface activity in rat lung lavage fluid
Klingebiel, R.; Heinrich, U.; Martin-Carrera, I.; Dettmer, M.; Kühn, A.; Bartsch, W.; Hoymann, H.-G.
Conference Paper
1993Effects of single and combined, subchronic exposure to ozone and soot particles on the pulmonary surfactant system and on biochemical and cellular markers of inflammation in the rat lung
Klingebiel, R.; Creutzenberg, O.; Bartsch, W.; Ernst, H.; Heinrich, U.; Muhle, H.
Journal Article
1993Goblet cell metaplasia in rat lungs after chronic exposure to particles
Kittel, B.; Dungworth, D.L.; Mohr, U.
Conference Paper
1993Long-term inhalation exposure of rats and mice to diesel exhaust (DE), carbon black (CB), and titanium dioxide (TiO2)
Heinrich, U.; Fuhst, R.; Dasenbrock, C.; Muhle, H.; Koch, W.; Mohr, U.
Conference Paper
1993Morphology and histogenesis of squamous cell metaplasia of the rat lung after chronic exposure to a pyrolized pitch condensate and/or carbon black, or to combinations of pyrolized pitch condensate, carbon black and irritant gases
Nolte, T.; Thiedemann, K.-U.; Dungworth, D.L.; Ernst, H.; Paulini, I.; Heinrich, U.; Dasenbrock, C.; Peters, L.; Ueberschär, S.; Mohr, U.
Journal Article
1993Morphometric evaluation of inhaled particles in sections of the lung
Kohler, M.; Aufderheide, M.; Ramm, D.
Conference Paper
1993The new born NMRI mouse, a very sensitive animal model to measure the carcinogenic potential of a PAH-containing test atmosphere by inhalation exposure
Heinrich, U.; Peters, L.; Dasenbrock, C.; Kamino, K.; Pott, F.
Conference Paper
1993Pathologic effects of inhaled particles in rat lungs - Associations between inflammatory and neoplastic processes
Dungworth, D.L.; Mohr, U.; Heinrich, U.; Ernst, H.; Kittel, B.
Conference Paper
1993Phagocytosis and chemotaxis of rat alveolar macrophages after a combined or separate exposure to ozone and carbon black
Creutzenberg, O.; Bellmann, B.; Klingebiel, R.; Heinrich, U.; Muhle, H.
Conference Paper
1993Toxic and carcinogenic effects of solid particles in the respiratory tract. Abstracts
 
Conference Proceedings
1993Toxicokinetics of solid particles in chronic studies - An overview
Muhle, H.
Conference Paper
1992Effect of photocorrosion on cadmium sulfide suspensions applied in animal inhalation studies with CdS particles
Heinrich, U.; Kock, H.; König, H.P.; Peters, L.
Journal Article
1992Hamster response to chronic test toner inhalation
Mermelstein, R.; Ernst, H.; Creutzenberg, O.; Dasenbrock, C.; Kuschner, M.; Mohr, U.; Muhle, H.
Journal Article
1992Das kanzerogene Potential von Luftschadstoffen - die Bedeutung von Kfz-Abgasen
Heinrich, U.
Conference Paper
1992Photocorrosion of cadmium sulfide suspensions applied in animal inhalation studies
Heinrich, U.; Kock, H.; König, H.P.; Peters, L.
Conference Paper
1992Pulmonary carcinogenicity of cadmium by inhalation in animals
Heinrich, U.
Conference Paper
1992Tierexperimentelle Inhalationsstudien zur Frage der tumorinduzierenden Wirkung von Dieselmotorabgasen und zwei Teststäuben
Heinrich, U.; Fuhst, R.; Mohr, U.
Book Article
1991Effects of 12 weeks exposure to a diisocyanate -MDI- on the pulmonary surfactant system and bronchoalveolar cell content in rats
Klingebiel, R.; Creutzenberg, O.; Hoymann, H.-G.; Dettmer, M.; Schüler, T.; Heinrich, U.
Conference Paper
1991How does the solubility of cadmium sulfide -CdS- affect the results of the inhalation studies with CdS particles?
Heinrich, U.; Kock, H.; König, H.P.; Peters, L.
Conference Paper
1990Alveolar retention and clearance of insoluble particle in rats simulated by a new physiology oriented compartmental kinetics model
Morawietz, G.; Morrow, P.E.; Stöber, W.
Journal Article
1990Ultrastructure of hamster and rat lungs after chronic inhalation exposure to cadmium compounds
Thiedemann, K.-U.; Kreft, A.; Lüthe, N.; Heinrich, U.; Glaser, U.; Abel, U.
Conference Paper
1989Modeling approaches - introduction
Stöber, W.
Conference Paper
1983Lung clearance after long time exposure of rats to airborne pollutants
Bellmann, Bernd; Muhle, Hartwig; Heinrich, Uwe
Journal Article
1982Investigation of toxic and carcinogenic effects of diesel exhaust on long-term inhalation exposure of rodents
Heinrich, U.; Peters, L.; Funcke, W.; Pott, F.; Mohr, U.; Stöber, W.
Book Article