Fraunhofer-Gesellschaft

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Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2020Alzheimer-related genes show accelerated evolution
Nitsche, Anne; Arnold, Christian; Ueberham, Uwe; Reiche, Kristin; Fallmann, Jörg; Hackermüller, Jörg; Stadler, Peter F.; Arendt, Thomas
Journal Article
2020Amyloid-beta peptides trigger aggregation of alpha-synuclein in vitro
Köppen, Janett; Schulze, Anja; Machner, Lisa; Wermann, Michael; Eichentopf, Rico; Guthardt, Max; Hähnel, Angelika; Klehm, Jessica; Kriegeskorte, Marie-Christin; Hartlage-Rübsamen, Maike; Morawski, Markus; Hörsten, Stephan von; Demuth, Hans-Ulrich; Roßner, Steffen; Schilling, Stephan
Journal Article
2020Antifibrotic effects of amyloid-beta and its loss in cirrhotic liver
Buniatian, Gayane Hrachia; Weiskirchen, Ralf; Weiss, Thomas S.; Schwinghammer, Ute; Fritz, Martin; Seferyan, Torgom; Proksch, Barbara; Glaser, Michael; Lourhmati, Ali; Buadze, Marine; Borkham-Kamphorst, Erawan; Gaunitz, Frank; Gleiter, Christoph H.; Lang, Thomas; Schaeffeler, Elke; Tremmel, Roman; Cynis, Holger; Frey II, William H.; Gebhardt, Rolf; Friedmann, Scott L.; Mikulits, Wolfgang; Schwab, Matthias; Danielyan, Lusine
Journal Article
2020Development of the clinical candidate PBD-C06, a humanized pGlu3-Aβ-specific antibody against Alzheimer's disease with reduced complement activation
Hettmann, Thore; Gillies, Stephen D.; Kleinschmidt, Martin; Piechotta, Anke; Makioka, Koki; Lemere, Cynthia A.; Schilling, Stephan; Rahfeld, Jens-Ulrich; Lues, Inge
Journal Article
2020Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models
Monasor, Laura Sebastian; Müller, Stephan A.; Colombo, Alessio Vittorio; Tanrioever, Gaye; König, Jasmin; Roth, Stefan; Liesz, Arthur; Berghofer, Anna; Piechotta, Anke; Prestel, Matthias; Saito, Takashi; Saido, Takaomi C.; Herms, Jochen; Willem, Michael; Haass, Christian; Lichtenthaler, Stefan F.; Tahirovic, Sabina
Journal Article
2020Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study
Brosseron, Frederic; Kolbe, Carl-Christian; Santarelli, Francesco; Carvalho, Stephanie; Antonell, Anna; Castro-Gomez, Sergio; Tacik, Pawel; Namasivayam, Aishwarya Alex; Mangone, Graziella; Schneider, Reinhard; Latz, Eicke; Wüllner, Ullrich; Svenningsson, Per; Sánchez-Valle, Raquel; Molinuevo, José Luis; Corvol, Jean-Christophe; Heneka, Michael T.; Hofmann-Apitius, Martin; Springstubbe, Stephan; Fröhlich, Holger et al.
Journal Article
2020Sterubin: Enantioresolution and configurational stability, enantiomeric purity in nature, and neuroprotective activity in vitro and in vivo
Hofmann, Julian; Fayez, Shaimaa; Scheiner, Matthias; Hoffmann, Matthias; Oerter, Sabrina; Appelt-Menzel, Antje; Maher, Pamela; Maurice, Tangui; Bringmann, Gerhard; Decker, Michael
Journal Article
2020Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer’s disease-like pathology
Gnoth, Kathrin; Piechotta, Anke; Kleinschmidt, Martin; Konrath, Sandra; Schenk, Mathias; Taudte, Nadine; Ramsbeck, Daniel; Nykiel, Vera; Geißler, Stefanie; Eichentopf, Rico; Barendrecht, Susan; Hartlage-Rübsamen, Maike; Demuth, Hans-Ulrich; Roßner, Steffen; Cynis, Holger; Rahfeld, Jens-Ulrich; Schilling, Stephan
Journal Article
2019QUINT: Workflow for quantification and spatial analysis of features in histological images from rodent brain
Yates, Sharon C.; Groeneboom, Nicolaas E.; Coello, Christopher; Lichtenthaler, Stefan F.; Kuhn, Peer-Hendrik; Demuth, Hans-Ulrich; Hartlage-Rübsamen, Maike; Roßner, Steffen; Leergaard, Trygve; Kreshuk, Anna; Puchades, Maja A.; Bjaalie, Jan G.
Journal Article
2019Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model
Costa-Marques, Luís; Arnold, Katrin; Pardon, Marie-Christine; Leovsky, Christiane; Swarbrick, Samantha; Fabian, Claire; Stolzing, Alexandra
Journal Article
2018Aβ oligomer eliminating compounds interfere successfully with pEAβ(3-42) induced motor neurodegenerative phenotype in transgenic mice
Dunkelmann, Tina; Teichmann, Kerstin; Ziehm, Tamar; Schemmert, Sarah; Frenzel, Daniel; Tusche, Markus; Dammers, Christina; Jürgens, Dagmar; Langen, Karl-Josef; Demuth, Hans-Ulrich; Shah, Nadim Jon; Kutzsche, Janine; Willuweit, Antje; Willbold, Dieter
Journal Article
2018Comprehensive Characterization of the Pyroglutamate Amyloid-β Induced Motor Neurodegenerative Phenotype of TBA2.1 Mice
Dunkelmann, Tina; Schemmert, Sarah; Honold, Dominik; Teichmann, Kerstin; Butzküven, Elke; Demuth, Hans-Ulrich; Shah, Nadim Joni; Langen, Karl-Josef; Kutzsche, Janine; Willbold, Dieter; Willuweit, Antje
Journal Article
2017Distribution pattern following systemic mesenchymal stem cell injection depends on the age of the recipient and neuronal health
Fabian, Claire; Naaldijk, Yahaira; Leovsky, Christiane; Johnson, Adiv A.; Rudolph, Lukas; Jäger, Carsten; Arnold, Katrin; Stolzing, Alexandra
Journal Article
2017Effect of systemic transplantation of bone marrow-derived mesenchymal stem cells on neuropathology markers in APP/PS1 Alzheimer mice
Naaldijk, Yahaira; Jäger, Carsten; Fabian, Claire; Leovsky, Christiane; Blüher, A.; Rudolph, Lukas; Hinze, Arnd; Stolzing, Alexandra
Journal Article
2017Recent progress in translational research on neurovascular and neurodegenerative disorders
Demuth, Hans-Ulrich; Dijkhuizen, Rick M.; Farr, Tracy D.; Gelderblom, Mathias; Horsburgh, Karen; Iadecola, Costantino; Mcleod, Damian D.; Michalski, Dominik; Murphy, Tim H.; Orbe, Josune; Otte, Wilem M.; Petzold, Gabor C.; Plesnila, Nikolaus; Reiser, Georg; Reymann, Klaus G.; Rueger, Maria P.; Saur, Dorothee; Savitz, Sean; Schilling, Stephan; Spratt, Neil J.; Turner, Renée J.; Vermuganti, Raghu; Vivien, Denis; Yepes, Manuel; Zille, Marietta; Boltze, Johannes
Journal Article
2016Enhanced fibril fragmentation of N-terminally truncated and Pyroglutamyl-modified Aβ peptides
Wulff, Melanie; Baumann, Monika; Thümmler, Anka; Yadav, Jay K.; Heinrich, Liesa; Knüpfer, Uwe; Schlenzig, Dagmar; Schierhorn, Angelika; Rahfeld, Jens-Ulrich; Horn, Uwe; Balbach, Jochen; Demuth, Hans-Ulrich; Fändrich, Marcus
Journal Article
2015Characterizing aging, mild cognitive impairment, and dementia with blood-based biomarkers and neuropsychology
Kleinschmidt, Martin; Schoenfeld, Robby; Göttlich, Claudia; Bittner, Daniel; Metzner, Jürgen Erich; Leplow, Bernd; Demuth, Hans-Ulrich
Journal Article
2015Detection and Quantification of β-Amyloid, Pyroglutamyl Aβ, and Tau in Aged Canines
Schmidt, Franziska; Boltze, Johannes; Jäger, Carsten; Hofmann, Sarah; Willems, Nicole; Seeger, Johannes; Härtig, Wolfgang; Stolzing, Alexandra
Journal Article
2014Environment-aware system for Alzheimer's patients
Barreto, Ana; Oliveira, Renato; Sousa, Filipe; Cardoso, Artur; Duarte, Cândido
Conference Paper
2014Glutaminyl cyclase in human cortex: Correlation with (pGlu)-amyloid-β load and cognitive decline in Alzheimer's disease
Morawski, Markus; Schilling, Stephan; Kreuzberger, Moritz; Waniek, Alexander; Jäger, Carsten; Koch, Birgit; Cynis, Holger; Kehlen, Astrid; Arendt, Thomas; Hartlage-Rübsamen, Maike; Demuth, Hans-Ulrich; Roßner, Steffen
Journal Article
2014Health care for people with dementia in 2030 - results of a multidisciplinary scenario process
Vollmar, H.C.; Goluchowicz, K.; Beckert, B.; Dönitz, E.; Bartholomeyczik, S.; Ostermann, T.; Boustani, M.; Buscher, I.
Journal Article
2014Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease
Ueberham, Uwe; Rohn, Susanne; Ueberham, Elke; Wodischeck, Susanne; Hilbrich, Isabel; Holzer, Max; Brückner, Martina K.; Gruschka, Hildegard; Arendt, Thomas
Journal Article
2013Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration
Becker, Andreas; Kohlmann, Stephanie; Alexandru, Anca; Jagla, Wolfgang; Canneva, Fabio; Bäuscher, Christoph; Cynis, Holger; Sedlmeier, Reinhard; Graubner, Sigrid; Schilling, Stephan; Demuth, Hans-Ulrich; Hörsten, Stephan von
Journal Article
2013A quantitative analysis of spontaneous isoaspartate formation from N-terminal asparaginyl and aspartyl residues
Güttler, Bert H.-O.; Cynis, Holger; Seifert, Franziska; Ludwig, Hans-Henning; Porzel, Andrea; Schilling, Stephan
Journal Article
2013STAlz: Remotely supporting the diagnosis, tracking and rehabilitation of patients with Alzheimer's
Moreira, Helder; Oliveira, Renato; Flores, Nuno
Conference Paper
2012Lack of detectable diffuse or neuritic plaques and neurofibrillary tangles in the brains of aged hamsters
Gerhauser, Ingo; Wohlsein, Peter; Ernst, Heinrich; Germann, Paul-Georg; Baumgärtner, Wolfgang
Journal Article
2012Neurovascular pathophysiology in cerebral ischemia, dementia and the ageing brain - current trends in basic, translational and clinical research
Boltze, Johannes; Kleinschnitz, Christoph; Reymann, Klaus G.; Reiser, Georg; Wagner, Daniel-Christoph; Kranz, Alexander; Michalski, Dominik
Journal Article
2012Structural analysis of the pyroglutamate-modified isoform of the Alzheimer's disease-related amyloid-β using NMR spectroscopy
Sun, Na; Hartmann, Rudolf; Lecher, Justin; Stoldt, Matthias; Funke, Susanne Aileen; Gremer, Lothar; Ludwig, Hans-Henning; Demuth, Hans-Ulrich; Kleinschmidt, Martin; Willbold, Dieter
Journal Article
2009Was die hausärztliche Leitlinie empfiehlt. Versorgung von Patienten mit Alzheimer-Demenz
Vollmar, H.C.
Journal Article
2006Simultaneous detection of tau phospho-epitopes with haptenylated antibodies
Härtig, W.; Lehmann, J.; Stieler, J.; Singer, D.; Grosche, J.; Arendt, T.; Hoffmann, J.
Journal Article
2006Temporal horn index and volume of medial temporal lobe atrophy using a new semiautomated method for rapid and precise assessment
Giesel, F.L.; Hahn, H.K.; Thomann, P.A.; Widjaja, E.; Wignall, E.; Tengg-Kobligk, H. von; Pantel, J.; Griffiths, P.D.; Peitgen, H.-O.; Schroder, J.; Eßig, M.
Journal Article