Waschki, B.; Kirsten, A.-M.; Holz, O.; Meyer, T.; Lichtinghagen, R.; Rabe, K.F.; Magnussen, H.; Welte, T.; Watz, H.; Janciauskiene, S.:
α1-Antitrypsin (a1at) serum levels as marker of systemic inflammation in non-A1at-deficient patients with COPD. (American Thoracic Society (ATS International Conference) <2016, San Francisco/Calif.>)
American Journal of Respiratory and Critical Care Medicine, Vol.193 (2016), Art. A3488
Fraunhofer ITEM


Bundschuh, Mirco; Hahn, Torsten; Ehrlich, Bert; Höltge, Sibylla; Kreuzig, Robert; Schulz, Ralf:
Acute toxicity and environmental risks of five veterinary pharmaceuticals for aquatic macroinvertebrates
Bulletin of environmental contamination and toxicology. BECT, Vol.96 (2016), No.2, pp.139-143
info:doi/10.1007/s00128-015-1656-8
Fraunhofer ITEM


Booth, J.L.; Duggan, E.S.; Patel, V.I.; Metcalf, J.; Langer, M.; Coggeshall, K.M.; Braun, A.:
Alveolar escape by bacillus anthracis spores does not require a carrier cell and is not altered by lethal toxin. (American Federation for Medical Research (AFMR Midwestern Regional Meeting) <2016, Chicago/Ill.>)
Journal of investigative medicine, Vol.64 (2016), No.4, pp.960-961
info:doi/10.1136/jim-2016-000120.101
Fraunhofer ITEM


Waschki, Benjamin; Kirsten, Anne-Marie; Holz, Olaf; Meyer, T.; Lichtinghagen, R.; Rabe, K.F.; Magnussen, Helgo; Welte, T.; Watz, H.; Janciauskiene, S.:
Angiopoietin-like protein 4 and cardiovascular function in COPD
BMJ Open Respiratory Research, Vol.3 (2016), Art. e000161, 8 pp.
urn:nbn:de:0011-n-4425606
info:doi/10.1136/bmjresp-2016-000161
Volltext
Fraunhofer ITEM


Behrsing, H.; Raabe, H.; Manuppello, J.; Bombick, B.; Curren, R.; Sullivan, K.; Sethi, S.; Phipps, R.; Tesfaigzi, Y.; Yan, S.; D'Ruiz, C.; Tarran, R.; Constant, S.; Phillips, G.; Gaca, M.; Hayden, P.; Cao, X.; Mathis, C.; Hoeng, J.; Braun, A.; Hill, E.:
Assessment of in vitro COPD models for tobacco regulatory science: Workshop proceedings, conclusions and paths forward for in vitro model use
Alternatives to laboratory animals : ATLA, Vol.44 (2016), No.2, pp.129-166
Fraunhofer ITEM


Metcalf, J.P.; Booth, J.L.; Duggan, E.S.; Patel, V.I.; Langer, M.; Braun, A.; Coggeshall, K.M.:
Bacillus anthracis spore movement and uptake by cells resident in the human lung are not affected by anthrax lethal toxin. (American Thoracic Society (ATS International Conference) <2016, San Francisco/Calif.>)
American Journal of Respiratory and Critical Care Medicine, Vol.193 (2016), Art. 5479
Fraunhofer ITEM


Booth, J.L.; Duggan, E.S.; Patel, V.I.; Langer, M.; Wu, W.; Braun, A.; Coggeshall, K.M.; Metcalf, J.P.:
Bacillus anthracis spore movement does not require a carrier cell and is not affected by lethal toxin in human lung models
Microbes and infection, Vol.18 (2016), No.10, pp.615-626
info:doi/10.1016/j.micinf.2016.06.004
Fraunhofer ITEM


Lamb, David J.; Wollin, Stefan Lutz; Schnapp, Andreas; Bischoff, Daniel; Erb, Klaus J.; Bouyssou, Thierry; Guilliard, Bernd; Strasser, Christine; Wex, Eva; Blum, Sylvia; Thaler, Eva; Nickel, Helga; Radmacher, Oliver; Haas, Hannah; Swantek, Jennifer L.; Souza, Don; Canfield, Melissa; White, Della; Panzenbeck, Mark; Kashem, Mohammed A.; Sanville-Ross, Mary; Kono, Takeshi; Sewald, Katherina; Braun, Armin; Obernolte, Helena; Danov, Olga; Schaenzle, Gerhard; Rast, Georg; Maier, Gerd-Michael; Hoffmann, Matthias:
BI 1002494, a novel potent and selective oral spleen tyrosine kinase inhibitor, displays differential potency in human basophils and B cells
The journal of pharmacology and experimental therapeutics, Vol.357 (2016), No.3, pp.554-561
info:doi/10.1124/jpet.116.233155
Fraunhofer ITEM


Honti, Mark; Hahn, Stefan; Hennecke, Dieter; Junker, Thomas; Shrestha, Prasit; Fenner, Kathrin:
Bridging across OECD 308 and 309 data in search of a robust biotransformation indicator
Environmental science and technology, Vol.50 (2016), No.13, pp.6865-6872
info:doi/10.1021/acs.est.6b01097
Fraunhofer IME IME-PUB-1615
Fraunhofer ITEM


Hackner, K.; Errhalt, P.; Mueller, M.R.; Speiser, M.; Marzluf, B.A.; Schulheim, A.; Schenk, P.; Bilek, J.; Doll, T.:
Canine scent detection for the diagnosis of lung cancer in a screening-like situation
Journal of breath research, Vol.10 (2016), No.4, 8 pp.
info:doi/10.1088/1752-7155/10/4/046003
Fraunhofer ITEM


Buschmann, J.:
Changes introduced with the new OECD 443 method and implications on the toxicological interpretation. (European Societies of Toxicology (EUROTOX Congress) <52, 2016, Seville>)
Toxicology letters, Vol.258 (2016), Supplement, pp.S52
info:doi/10.1016/j.toxlet.2016.06.1286
Fraunhofer ITEM


Dunkhorst, Wilhelm; Lipowicz, Peter; Koch, Wolfgang:
Characterization of highly concentrated organic aerosols by optical extinction in the mid infrared regime: Application to e-cigarettes
Journal of Aerosol Science, Vol.94 (2016), pp.33-42
info:doi/10.1016/j.jaerosci.2015.12.004
Fraunhofer ITEM


Ebinger, S.; Özdemir, E.Z.; Ziegenhain, C.; Tiedt, S.; Castro Alves, C.; Grunert, M.; Dworzak, M.; Lutz, C.; Turati, V.A.; Enver, T.; Horny, H.-P.; Sotlar, K.; Parekh, S.; Spiekermann, K.; Hiddemann, W.; Schepers, A.; Polzer, B.; Kirsch, S.; Hoffmann, M.; Knapp, B.; Hasenauer, J.; Pfeifer, H.; Panzer-Grümayer, R.; Enard, W.; Gires, O.; Jeremias, I.:
Characterization of rare, dormant, and therapy-resistant cells in acute lymphoblastic leukemia
Cancer cell, Vol.30 (2016), No.6, pp.849-862
info:doi/10.1016/j.ccell.2016.11.002
Fraunhofer ITEM


Obernolte, H.; Ritter, D.; Knebel, J.W.; Braubach, P.; Jonigk, D.; Fieguth, H.-G.; Braun, A.; Sewald, K.:
Cigarette smoke and cigarette smoke condensate induce early biomarkers of inflammation and cytotoxicity in precision-cut lung slices. (American Thoracic Society (ATS International Conference) <2016, San Francisco/Calif.>)
American Journal of Respiratory and Critical Care Medicine, Vol.193 (2016), Art. A1427
Fraunhofer ITEM


Gong, Yijian; Capstick, Myles; Dasenbrock, Clemens; Fedrowitz, Maren; Cobaleda, Cesar; Sanchez-Garcia, Isidro; Kuster, Niels:
Comparative dosimetry for children and rodents exposed to extremely low-frequency magnetic fields
Bioelectromagnetics, Vol.37 (2016), No.5, pp.310-322
info:doi/10.1002/bem.21976
Fraunhofer ITEM


Holz, O.; Allers, M.; Gaida, A.; Schuchardt, S.; Hohlfeld, J.M.; Zimmermann, S.:
Comparison Of COPD related breath VOCs assessed by a compact high-resolution closed-loop GC-IMS and by standard GC-MS. (American Thoracic Society (ATS International Conference) <2016, San Francisco/Calif.>)
American Journal of Respiratory and Critical Care Medicine, Vol.193 (2016), Art. A1434
Fraunhofer ITEM


Feldmann, Jörg; Raab, Andrea; Hansen, Helle R.; Blümlein, Katharina; Wallschläger, Dirk:
Compounds with As-S bonds: Analytical and biogeochemical reasons why these species have been elusive in biota and environment: Chapter 7.2
Michalke, B.: Metallomics. Analytical techniques and speciation methods. Weinheim: Wiley-VCH, 2016, pp. 202-221
Fraunhofer ITEM


Gong, Yijian; Capstick, Myles; Tillmann, Thomas; Dasenbrock, Clemens; Samaras, Theodoros; Kuster, Niels:
Desktop exposure system and dosimetry for small scale in vivo radiofrequency exposure experiments
Bioelectromagnetics, Vol.37 (2016), No.1, pp.49-61
info:doi/10.1002/bem.21950
Fraunhofer ITEM


Ritter, D.; Knebel, J.; Wronski, S.; Montes, A.; Niehof, M.:
Development of an in vitro testing platform for aerosols containing inhalable antiobiotically active compounds as a part of the EU-project "PNeumoNP". (European Societies of Toxicology (EUROTOX Congress) <52, 2016, Seville>)
Toxicology letters, Vol.258 (2016), Supplement, pp.S146
info:doi/10.1016/j.toxlet.2016.06.1565
Fraunhofer ITEM


Prasse, A.:
The Diagnosis, Differential Diagnosis, and Treatment of Sarcoidosis
Deutsches Ärzteblatt international, Vol.113 (2016), No.33-34, pp.565-574
info:doi/10.3238/arztebl.2016.0565
Fraunhofer ITEM


Konzok, S.; Braubach, P.; Peter, D.; Jonigk, D.; Fieguth, H.-G.; Braun, A.; Sewald, K.:
Different pathways of inflammasome activation in human precision-cut lung slices (PCLS). (American Thoracic Society (ATS International Conference) <2016, San Francisco/Calif.>)
American Journal of Respiratory and Critical Care Medicine, Vol.193 (2016), Art. A1425
Fraunhofer ITEM


Wagenmann, M.; Hohlfeld, J.; Tribanek, M.; Homolla, V.; Karjalainen, M.; Häfner, D.:
Double-blind randomized multicenter clinical trial to evaluate the specific and non-specific effects of AIT with a grass and a birch pollen allergoid. (European Academy of Allergy and Clinical Immunology (EAACI Congress) <2016, Vienna>)
Allergy. European journal of allergy and clinical immunology, Vol.71 (2016), Supplement S102, pp.509
Fraunhofer ITEM


Gaida, Arne; Holz, Olaf; Nell, Christoph; Schuchardt, Sven; Lavae-Mokhtari, Bianca; Kruse, Lena; Boas, Ursula; Langejuergen, Jens; Allers, Maria; Zimmermann, Stefan:
A dual center study to compare breath volatile organic compounds from smokers and non-smokers with and without COPD
Journal of breath research, Vol.10 (2016), No.2, Art. 026006, 19 pp.
urn:nbn:de:0011-n-3936093
info:doi/10.1088/1752-7155/10/2/026006
Volltext
Fraunhofer ITEM


Hosseini, Hedayatollah; Obradović, Milan M.S.; Hoffmann, Martin; Harper, Kathryn L.; Sosa, Maria Soledad; Werner-Klein, Melanie; Nanduri, Lahiri Kanth; Werno, Christian; Ehrl, Carolin; Maneck, Matthias; Patwary, Nina; Haunschild, Gundula; Gužvić, Miodrag; Reimelt, Christian; Grauvogl, Michael; Eichner, Norbert; Weber, Florian; Hartkopf, Andreas D.; Taran, Florin-Andrei; Brucker, Sara Y.; Fehm, Tanja; Rack, Brigitte; Buchholz, Stefan; Spang, Rainer; Meister, Gunter; Aguirre-Ghiso, Julio A.; Klein, Christoph A.:
Early dissemination seeds metastasis in breast cancer
Nature, Vol.540 (2016), 7634, pp.552-558
info:doi/10.1038/nature20785
Fraunhofer ITEM


Wichmann, J.; Jimenez-Delgado, S.; Curths, C.; Schmitt, A.; Dunker, S.; Jonigk, D.; Braubach, P.; Kaup, F.-J.; Braun, A.; Eggel, A.; Dahlmann, F.; Sewald, K.; Knauf, S.:
Efficacy assessment of a novel disruptive IgE inhibitor in non-human primate and human precision-cut lung slices. (American Thoracic Society (ATS International Conference) <2016, San Francisco/Calif.>)
American Journal of Respiratory and Critical Care Medicine, Vol.193 (2016), Art. A6684
Fraunhofer ITEM


Subramanian, Deepak R.; Gupta, Sumit; Burggraf, Dorothe; Silberberg, Suzan J. vom; Heimbeck, Irene; Heiss-Neumann, Marion S.; Haeussinger, Karl; Newby, Chris; Hargadon, Beverley; Raj, Vimal; Singh, Dave; Kolsum, Umme; Hofer, Thomas P.; Al-Shair, Khaled; Luetzen, Niklas; Prasse, Antje; Müller-Quernheim, Joachim; Benea, Giorgio; Leprotti, Stefano; Boschetto, Piera; Gorecka, Dorota; Nowinski, Adam; Oniszh, Karina; Castell, Wolfgang zu; Hagen, Michael; Barta, Imre; Döme, Balazs; Strausz, Janos; Greulich, Timm; Vogelmeier, Claus; Koczulla, Andreas R.; Gut, Ivo; Hohlfeld, Jens; Welte, Tobias; Lavae-Mokhtari, Mahyar; Ziegler-Heitbrock, Loems; Brightling, Christopher; Parr, David G.:
Emphysema- and airway-dominant COPD phenotypes defined by standardised quantitative computed tomography
European Respiratory Journal, Vol.48 (2016), No.1, pp.92-103
info:doi/10.1183/13993003.01878-2015
Fraunhofer ITEM


Schäfers, C.; Licht, O.; Bitsch, A.:
Endocrine active environmental chemicals in foods
Pädiatrische Praxis, Vol.58 (2016), No.1, pp.171-181
Fraunhofer IME
Fraunhofer ITEM


Schäfers, C.; Licht, O.; Bitsch, A.:
Endokrin wirksame Umweltchemikalien in Lebensmitteln: Endocrine active environmental chemicals in foods
Internistische Praxis, Vol.57 (2016), No.1, pp.175-185
Fraunhofer IME
Fraunhofer ITEM


Schäfers, C.; Licht, O.; Bitsch, A.:
Endokrin wirksame Umweltchemikalien in Lebensmitteln
Chirurgische Praxis, Vol.81 (2016), No.4, pp.731-742
Fraunhofer IME
Fraunhofer ITEM


Schäfers, C.; Licht, O.; Bitsch, A.:
Endokrin wirksame Umweltchemikalien in Lebensmitteln
Tägliche Praxis, Vol.58 (2016), No.1, pp.171-181
Fraunhofer IME
Fraunhofer ITEM


Schäfers, C.; Licht, O.; Bitsch, A.:
Endokrin wirksame Umweltchemikalien in Lebensmitteln
Gynäkologische Praxis, Vol.41 (2016), No.2, pp.359-371
Fraunhofer IME
Fraunhofer ITEM


Meinlschmidt, Pia; Schweiggert-Weisz, Ute; Brode, V.; Eisner, Peter:
Enzyme assisted degradation of potential soy protein allergens with special emphasis on the technofunctionality and the avoidance of a bitter taste formation
LWT - food science and technology, Vol.68 (2016), pp.707-716
info:doi/10.1016/j.lwt.2016.01.023
Fraunhofer IVV 3408
Fraunhofer ITEM


Borlak, J.; Buettner, S.M.R.:
Epigenetic silencing of the lung tumor suppressor cell adhesion molecule 1. (European Societies of Toxicology (EUROTOX Congress) <52, 2016, Seville>)
Toxicology letters, Vol.258 (2016), Supplement, pp.S92
info:doi/10.1016/j.toxlet.2016.06.1404
Fraunhofer ITEM


May, M.; Drost, W.; Germer, S.; Juffernholz, T.; Hahn, S.:
Evaluation of acute-to-chronic ratios of fish and Daphnia to predict acceptable no-effect levels
Environmental Sciences Europe : ESEU, Vol.28 (2016), No.1, 9 pp.
info:doi/10.1186/s12302-016-0084-7
Fraunhofer ITEM


Schröder, Katrin; Escher, Sylvia E.; Hoffmann-Dörr, Simone; Kühne, R.; Simetska, Nelly; Mangelsdorf, Inge:
Evaluation of route-to-route extrapolation factors based on assessment of repeated dose toxicity studies compiled in the database RepDose®
Toxicology letters, Vol.261 (2016), pp.32-40
info:doi/10.1016/j.toxlet.2016.08.013
Fraunhofer ITEM


May, Martin; Drost, Wiebke; Germer, Sabine; Juffernholz, Tanja; Hahn, Stefan:
Evaluation of the integrated testing strategy for PNEC derivation under REACH
Regulatory toxicology and pharmacology, Vol.78 (2016), pp.59-65
info:doi/10.1016/j.yrtph.2016.04.004
Fraunhofer ITEM


Brodbeck, Carsten; Ritter, Detlef; Knebel, Jan; Wolf, Klaus:
Expositionsvorrichtung
2016
Fraunhofer ITEM


Tran, Doan Duy Hai; Koch, Alexandra; Saran, Shashank; Armbrecht, Marcel; Ewald, Florian; Koch, Martina; Wahlicht, Tom; Wirth, Dagmar; Braun, Armin; Nashan, Bjorn; Gaestel, Matthias; Tamura, Teruko:
Extracellular-signal regulated kinase (Erk1/2), mitogen-activated protein kinase-activated protein kinase 2 (MK2) and tristetraprolin (TTP) comprehensively regulate injury-induced immediate early gene (IEG) response in in vitro liver organ culture
Cellular signalling, Vol.28 (2016), No.5, pp.438-447
info:doi/10.1016/j.cellsig.2016.02.007
Fraunhofer ITEM


Schüz, Joachim; Dasenbrock, Clemens; Ravazzani, Paolo; Röösli, Martin; Schär, Primo; Bounds, Patricia L.; Erdmann, Friederike; Borkhardt, Arndt; Cobaleda, Cesar; Fedrowitz, Maren; Hamnerius, Yngve; Sanchez-Garcia, Isidro; Seger, Rony; Schmiegelow, Kjeld; Ziegelberger, Gunde; Capstick, Myles; Manser, Melissa; Müller, Meike; Schmid, Christoph D.; Schürmann, David; Struchen, Benjamin; Kuster, Niels:
Extremely low-frequency magnetic fields and risk of childhood leukemia: A risk assessment by the ARIMMORA consortium
Bioelectromagnetics, Vol.37 (2016), No.3, pp.183-189
info:doi/10.1002/bem.21963
Fraunhofer ITEM


Wiesner, Jochen; Ziemann, Christina; Hintz, Martin; Reichenberg, Armin; Ortmann, Regina; Schlitzer, Martin; Fuhst, Rainer; Timmesfeld, Nina; Vilcinskas, Andreas; Jomaa, Hassan:
FR-900098, an antimalarial development candidate that inhibits the non-mevalonate isoprenoid biosynthesis pathway, shows no evidence of acute toxicity and genotoxicity
Virulence, Vol.7 (2016), No.6, pp.718-728
info:doi/10.1080/21505594.2016.1195537
Fraunhofer IME
Fraunhofer ITEM


Fraunhofer-Institut für Toxikologie und Experimentelle Medizin -ITEM-, Hannover:
Fraunhofer-Institut für Toxikologie und Experimentelle Medizin. Leistungen und Ergebnisse. Jahresbericht 2015
Hannover: Fraunhofer ITEM, 2016
urn:nbn:de:0011-n-4048268
Volltext
Fraunhofer ITEM


Hoymann, H.G.; Schaudien, D.; Hansen, T.; Niehof, M.; Braun, A.:
Functional, histological and biochemical endpoints for assessing antifibrotic efficacy in a rat model of pulmonary fibrosis. (American Thoracic Society (ATS International Conference) <2016, San Francisco/Calif.>)
American Journal of Respiratory and Critical Care Medicine, Vol.193 (2016), Art. A4172
Fraunhofer ITEM


Ernst, Heinrich; Ma-Hock, Lan; Keller, J.; Groeters, Sibylle; Ravenzwaay, Bennard van; Gebel, Thomas; Schaudien, Dirk; Rittinghausen, Susanne; Landsiedel, Robert:
Histopathological findings after 12 months inhalation to nano Ceria. (Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie (Annual Meeting) <82, 2016, Berlin>)
Naunyn-Schmiedebergs archives of pharmacology, Vol.389 (2016), Supplement 1, pp.S53, Abstract 219
Fraunhofer ITEM


Farcal, L.; Ziemann, C.; Oliveira, H.; Burla, S.; Creutzenberg, O.:
In vitro and in vivo investigations to obtain validated toxicity data of graphene nanoplatelets. (European Societies of Toxicology (EUROTOX Congress) <52, 2016, Seville>)
Toxicology letters, Vol.258 (2016), Supplement, pp.S261
info:doi/10.1016/j.toxlet.2016.06.1921
Fraunhofer ITEM


Mangelsdorf, Inge; Nordqvist Kleppe, Sara; Heinzow, Birger; Sagunski, Helmut:
Indoor air guide values for glycol ethers and glycol esters - A category approach
International journal of hygiene and environmental health, Vol.219 (2016), No.4-5, pp.419-436
info:doi/10.1016/j.ijheh.2016.04.006
Fraunhofer ITEM


Schüürmann, Gerrit; Ebert, Ralf-Uwe; Tluczkiewicz, Inga; Escher, S.E.; Kühne, R.:
Inhalation threshold of toxicological concern (TTC) - structural alerts discriminate high from low repeated-dose inhalation toxicity
Environment international, Vol.88 (2016), pp.123-132
info:doi/10.1016/j.envint.2015.12.005
Fraunhofer ITEM


Tluczkiewicz, Inga; Kühne, Ralph; Ebert, Ralf-Uwe; Batke, Monika; Schüürmann, Gerrit; Mangelsdorf, Inge; Escher, Sylvia E.:
Inhalation TTC values: A new integrative grouping approach considering structural, toxicological and mechanistic features
Regulatory toxicology and pharmacology, Vol.78 (2016), pp.8-23
info:doi/10.1016/j.yrtph.2016.03.022
Fraunhofer ITEM


Batke, Monika; Gütlein, Martin; Partosch, Falko; Gundert-Remy, Ursula; Helma, Christoph; Kramer, Stefan; Maunz, Andreas; Seeland, Madeleine; Bitsch, Annette:
Innovative strategies to develop chemical categories using a combination of structural and toxicological properties
Frontiers in pharmacology, Vol.7 (2016), Art. 321, 19 pp.
urn:nbn:de:0011-n-4189792
info:doi/10.3389/fphar.2016.00321
Volltext
Fraunhofer ITEM


Bonella, Francesco; Kreuter, Michael; Hagmeyer, Lars; Neurohr, Claus; Keller, Claus; Kohlhaeufl, Martin J.; Müller-Quernheim, Joachim; Milger, Katrin; Prasse, Antje; Behr, J.; Hetzel, J.; Idzko, M.; Kardos, P.; Koch, A.; Markart, P.; Reichenberger, F.; Schumann, C.; Westhoff, M.; Windisch, W.:
Insights from the German Compassionate Use Program of Nintedanib for the Treatment of Idiopathic Pulmonary Fibrosis
Respiration, Vol.92 (2016), No.2, pp.98-106
urn:nbn:de:0011-n-4217207
info:doi/10.1159/000448288
Volltext
Fraunhofer ITEM


Gundlach, Enken; Hoffmann, Michael Marcus; Prasse, Antje; Heinzelmann, Sonja; Ness, Thomas:
Interleukin-2 receptor and angiotensin-converting enzyme as markers for ocular sarcoidosis
PLoS one. Online journal, Vol.11 (2016), No.1, Art. e0147258, 11 pp.
urn:nbn:de:0011-n-3821892
info:doi/10.1371/journal.pone.0147258
Volltext
Fraunhofer ITEM


Brinkman, P.; Wagener, A.H.; Hekking, P.-P.; Bansal, A.T.; Wang, Y.; Weda, H.; Knobel, H.H.; Vink, T.J.; Rattray, N.J.; D'Amico, A.; Pennazza, G.; Santonico, M.; Bakke, P.S.; Caruso, M.; Chung, K.F.; Corfield, J.; Dahlen, S.E.; Djukanovic, R.; Geiser, T.; Horvath, I.; Krug, N.; Musial, J.; Shaw, D.E.; Pandis, I.; Sandstrom, T.; Sousa, A.R.; Montuschi, P.; Fowler, S.J.; Sterk, P.J.:
Longitudinal replication of severe asthma exhaled breath phenotypes by the U-BIOPRED electronic nose platform. (American Thoracic Society (ATS International Conference) <2016, San Francisco/Calif.>)
American Journal of Respiratory and Critical Care Medicine, Vol.193 (2016), Art. A4329
Fraunhofer ITEM


Curths, C.; Jimenez-Delgado, S.; Wichmann, J.; Kap, Y.; Kaup, F.-J.; Braun, A.; Sewald, K.; Knauf, S.; Dahlmann, F.:
Marmoset monkeys as a model for human allergic asthma. (American Thoracic Society (ATS International Conference) <2016, San Francisco/Calif.>)
American Journal of Respiratory and Critical Care Medicine, Vol.193 (2016), Art. A4919
Fraunhofer ITEM


Selich, Anton; Daudert, Jannik; Hass, Ralf; Philipp, Friederike; Kaisenberg, Constantin von; Paul, Gabi; Cornils, Kerstin; Fehse, Boris; Rittinghausen, Susanne; Schambach, Axel; Rothe, Michael:
Massive clonal selection and transiently contributing clones during expansion of mesenchymal stem cell cultures revealed by lentiviral RGB-barcode technology
Stem cells translational medicine : SCTM, Vol.5 (2016), No.5, pp.591-601
info:doi/10.5966/sctm.2015-0176
Fraunhofer ITEM


Gilfanov, Artur K.; Koch, Wolfgang; Zaripov, Shamil K.:
Mathematical modeling of di-ethyl-hexyl-sebacate nanoparticle formation in a free turbulent jet under high nucleation rate conditions
Journal of Aerosol Science, Vol.96 (2016), pp.124-139
info:doi/10.1016/j.jaerosci.2016.02.004
Fraunhofer ITEM


Allers, Maria; Langejuergen, Jens; Gaida, Arne; Holz, Olaf; Schuchardt, Sven; Hohlfeld, Jens M.; Zimmermann, Stefan:
Measurement of exhaled volatile organic compounds from patients with chronic obstructive pulmonary disease (COPD) using closed gas loop GC-IMS and GC-APCI-MS
Journal of breath research, Vol.10 (2016), No.2, Art. 026004, 11 pp.
info:doi/10.1088/1752-7155/10/2/026004
Fraunhofer ITEM


Harper, Kathryn L.; Sosa, Maria Soledad; Entenberg, David; Hosseini, Hedayatollah; Cheung, Julie F.; Nobre, Rita; Avivar-Valderas, Alvaro; Nagi, Chandandaneep; Girnius, Nomeda; Davis, Roger J.; Farias, Eduardo F.; Condeelis, John; Klein, Christoph A.; Aguirre-Ghiso, Julio A.:
Mechanism of early dissemination and metastasis in Her2+ mammary cancer
Nature, Vol.540 (2016), No.7634, pp.588-592
info:doi/10.1038/nature20609
Fraunhofer ITEM


Veith, Nathalie; Ziehr, Holger; MacLeod, Roderick A.F.; Reamon-Büttner, Stella Marie:
Mechanisms underlying epigenetic and transcriptional heterogeneity in Chinese hamster ovary (CHO) cell lines
BMC biotechnology. Online journal, Vol.16 (2016), Art.6, 16 pp.
urn:nbn:de:0011-n-3821903
info:doi/10.1186/s12896-016-0238-0
Volltext
Fraunhofer ITEM


Creutzenberg, O.; Hansen, T.; Sven, S.; Thomas, T.; Jan, K.:
Method for identification of low soluble, biopersistent dusts (GBS). (European Societies of Toxicology (EUROTOX Congress) <52, 2016, Seville>)
Toxicology letters, Vol.258 (2016), Supplement, pp.S197-S198
info:doi/10.1016/j.toxlet.2016.06.1722
Fraunhofer ITEM


Creutzenberg, Otto H.; Hansen, Tanja; Schuchardt, Sven; Tillmann, Thomas; Knebel, Jan:
Method for identification of low soluble, biopersistent susts (GBS) - comparison of intratracheal installation and subacute inhalation. (Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie (Annual Meeting) <82, 2016, Berlin>)
Naunyn-Schmiedebergs archives of pharmacology, Vol.389 (2016), Supplement 1, pp.S47, Abstract 189
Fraunhofer ITEM


Suzuki, Toru; Asami, Maki; Hoffmann, Martin; Lu, Xin; Guzvic, Miodrag; Klein, Christoph A.; Perry, Anthony C.F.:
Mice produced by mitotic reprogramming of sperm injected into haploid parthenogenotes
Nature Communications, Vol.7 (2016), Art. 12676, 15 pp.
urn:nbn:de:0011-n-4216921
info:doi/10.1038/ncomms12676
Volltext
Fraunhofer ITEM


Bleyer, Martina; Curths, Christoph; Dahlmann, Franziska; Wichmann, Judy; Bauer, Natali; Moritz, Andreas; Braun, Armin; Knauf, Sascha; Kaup, Franz-Josef; Gruber-Dujardin, Eva:
Morphology and staining behavior of neutrophilic and eosinophilic granulocytes of the common marmoset (Callithrix jacchus)
Experimental and Toxicologic Pathology, Vol.68 (2016), No.6, pp.335-343
info:doi/10.1016/j.etp.2016.05.002
Fraunhofer ITEM


Sundarasetty, B.S.; Schneider, A.; Sewald, K.; Rittinghausen, S.; Braun, A.; Figueiredo, C.; Ganser, A.; Stripecke, R.:
No GVHD, but Human Inflammatory "Cytokine Storm" and Mouse Macrophage Activation Upon Accelerated Development of Human CD4+ Effector Memory T Cells in Long-Term Humanized Mice. (American Society of Gene & Cell Therapy (ASGCT Annual Meeting) <19, 2016, Washington/DC>)
Molecular therapy, Vol.24 (2016), Supplement 1, pp.S188
Fraunhofer ITEM


Fossey, Stacey; Vahle, John; Long, Philip; Schelling, Scott; Ernst, Heinrich; Boyce, Rogely Waite; Jolette, Jacquelin; Bolon, Brad; Bendele, Alison; Rinke, Matthias; Healy, Laura; High, Wanda; Roth, Daniel Robert; Boyle, Michael; Leininger, Joel:
Nonproliferative and proliferative lesions of the rat and mouse skeletal tissues (bones, joints, and teeth)
Journal of toxicologic pathology, Vol.29 (2016), No.3, Supplement, pp.49S-103S
urn:nbn:de:0011-n-4189803
info:doi/10.1293/tox.29.3S-2
Volltext
Fraunhofer ITEM


Wichmann, J.; Jimenez-Delgado, S.; Curths, C.; Schmitt, A.; Dunker, S.; Jonigk, D.; Braubach, P.; Kaup, F.J.; Braun, A.; Dahlmann, F.; Eggel, A.; Sewald, K.; Knauf, S.:
A novel disruptive IgE inhibitor: Efficacy assessment in non-human primate and human precision-cut lung slices. (European Academy of Allergy and Clinical Immunology (EAACI Congress) <2016, Vienna>)
Allergy. European journal of allergy and clinical immunology, Vol.71 (2016), Supplement S102, pp.223
Fraunhofer ITEM


Gilfanov, A.K.; Koch, W.; Zaripov, S.K.; Rybdylova, O.D.:
Numerical study of nanoparticle formation in a free turbulent jet. (International Conference on "Mesh Methods for Boundary-Value Problems and Applications" <11, 2016, Kazan>)
Institute of Physics -IOP-, London: 11th International Conference on "Mesh Methods for Boundary-value Problems and Applications" 2016: 20-25 October 2016, Kazan, Russia. Bristol: IOP Publishing, 2016. (IOP conference series. Materials science and engineering 158), Art. 012039, 7 pp.
info:doi/10.1088/1757-899X/158/1/012039
Fraunhofer ITEM


Badorrek, P.; Krug, N.; Hohlfeld, J.M.:
Prevalence of ragweed sensitization at a clinical trial unit in northern Germany. (European Academy of Allergy and Clinical Immunology (EAACI Congress) <2016, Vienna>)
Allergy. European journal of allergy and clinical immunology, Vol.71 (2016), Supplement 102, pp.484
Fraunhofer ITEM


Hess, A.; Wang-Lauenstein, Lan; Braun, Armin; Kolle, S.N.; Landsiedel, Robert; Liebsch, M.; Ma-Hock, Lan; Pirow, R.; Schneider, X.; Steinfath, M.; Vogel, S.; Martin, C.; Sewald, Katherina:
Prevalidation of the ex-vivo model PCLS for prediction of respiratory toxicity
Toxicology in vitro, Vol.32 (2016), pp.347-361
urn:nbn:de:0011-n-4043519
info:doi/10.1016/j.tiv.2016.01.006
Volltext
Fraunhofer ITEM


Holz, O.; Gaida, A.; Nell, C.; Allers, M.; Schuchardt, S.; Zimmermann, S.; Koczulla, R.; Hohlfeld, J.M.:
Rating the value of COPD related breath VOCs in models created by linear discriminant analysis. (American Thoracic Society (ATS International Conference) <2016, San Francisco/Calif.>)
American Journal of Respiratory and Critical Care Medicine, Vol.193 (2016), Art. A3498
Fraunhofer ITEM


Elmore, Susan A.; Dixon, Darlene; Hailey, James R.; Harada, Takanori; Herbert, Ronald A.; Maronpot, Robert R.; Nolte, Thomas; Rehg, Jerold E.; Rittinghausen, Susanne; Rosol, Thomas J.; Satoh, Hiroshi; Vidal, Justin D.; Willard-Mack, Cynthia L.; Creasy, Dianne M.:
Recommendations from the INHAND Apoptosis/Necrosis Working Group
Toxicologic Pathology, Vol.44 (2016), No.2, pp.173-188
info:doi/10.1177/0192623315625859
Fraunhofer ITEM


Api, A.M.; Belsito, D.; Bhatia, S.; Bruze, M.; Burton, G.A.; Buschmann, Jochen; Calow, P.; Dagli, M.L.; Dekant, W.; Fryer, A.D.; Kromidas, L.; La Cava, S.; Lapczynski, A.; Liebler, D.C.; O'Brien, D.; Parakhia, R.; Penning, T.M.; Politano, V.T.; Ritacco, G.; Salvito, D.; Schultz, T.W.; Shen, J.; Sipes, I.G.; Wall, B.; Wilcox, D.K.:
RIFM fragrance ingredient safety assessment, 2-Hydroxy-α,α,4-trimethylcyclohexanemethanol, CAS Registry Number 42822-86-6: short review
Food and Chemical Toxicology : FCT, Vol.97 (2016), Supplement, pp.S209-S215
info:doi/10.1016/j.fct.2016.10.009
Fraunhofer ITEM


Lüer, Katrin; Biller, Heike; Casper, Anja; Windt, Horst; Müller, Meike; Badorrek, Philipp; Haefner, Dietrich; Framke, Theodor; Koch, A.; Ziehr, Holger; Krug, Norbert; Koch, Wolfgang; Hohlfeld, Jens M.:
Safety, efficacy and repeatability of a novel house dust mite allergen challenge technique in the Fraunhofer allergen challenge chamber
Allergy. European journal of allergy and clinical immunology, Vol.71 (2016), No.12, pp.1693-1700
info:doi/10.1111/all.12947
Fraunhofer ITEM


Nendza, Monika; Wenzel, Andrea; Müller, Martin; Lewin, Geertje; Simetska, Nelly; Stock, Frauke; Arning, Jürgen:
Screening for potential endocrine disruptors in fish: Evidence from structural alerts and in vitro and in vivo toxicological assays
Environmental Sciences Europe : ESEU, Vol.28 (2016), Art. 26, 19 pp.
info:doi/10.1186/s12302-016-0094-5
Fraunhofer IME IME-PUB-1623
Fraunhofer ITEM


Wilson, Susan J.; Ward, Jonathan A.; Sousa, Ana R.; Corfield, Julie; Bansal, Aruna T.; Meulder, Bertrand de; Lefaudeux, Diane; Auffray, Charles; Loza, Matthew J.; Baribaud, Frédéric; Fitch, Neil; Sterk, Peter J.; Chung, Kian Fan; Gibeon, David; Sun, Kai; Guo, Yi-Ke; Adcock, Ian M.; Djukanovic, Ratko; Dahlén, Barbro; Chanez, Pascal; Shaw, Dominick E.; Krug, Norbert; Hohlfeld, Jens; Sandström, Thomas; Howarth, Peter H.:
Severe asthma exists despite suppressed tissue inflammation: Findings of the U-BIOPRED study
European Respiratory Journal, Vol.48 (2016), No.5, pp.1307-1319
info:doi/10.1183/13993003.01129-2016
Fraunhofer ITEM


Lüer, K.:
Sicherheit, Wirksamkeit und Reproduzierbarkeit einer neuen Provokationstechnik mit Hausstaubmilben im Fraunhofer-Allergenprovokationsraum
Hannover, Medizinische Hochschule, Diss., 2016
Fraunhofer ITEM


Shrestha, Prasit; Junker, Thomas; Fenner, Kathrin; Hahn, Stefan; Honti, Mark; Bakkour, Rani; Diaz, Cecilia; Hennecke, Dieter:
Simulation studies to explore biodegradation in water-sediment systems: From OECD 308 to OECD 309
Environmental science and technology, Vol.50 (2016), No.13, pp.6856-6864
info:doi/10.1021/acs.est.6b01095
Fraunhofer IME IME-PUB-1616
Fraunhofer ITEM


Alberter, Barbara; Klein, Christoph A.; Polzer, Bernhard:
Single-cell analysis of CTCs with diagnostic precision: Opportunities and challenges for personalized medicine. Review
Expert review of molecular diagnostics, Vol.16 (2016), No.1, pp.25-38
info:doi/10.1586/14737159.2016.1121099
Fraunhofer ITEM


Heinrichs, Martin; Ernst, Heinrich:
Spontaneous malignant craniopharyngioma in an aged Wistar rat
Journal of toxicologic pathology, Vol.29 (2016), No.3, pp.195-199
urn:nbn:de:0011-n-4220006
info:doi/10.1293/tox.2016-0004
Volltext
Fraunhofer ITEM


Le, Duc Dung; Funck, Ulrike; Wronski, Sabine; Heck, Sebastian; Tschernig, Thomas; Bischoff, Markus; Sester, Martina; Herr, Christian; Bals, Robert; Welte, Tobias; Braun, Armin; Dinh, Quoc Thai:
Steroid treatment reduces allergic airway inflammation and does not alter the increased numbers of dendritic cells and calcitonin gene-related peptide-expressing neurons in airway sensory ganglia
Neuroimmunomodulation, Vol.23 (2016), No.1, pp.18-26
info:doi/10.1159/000440622
Fraunhofer ITEM


Escher, S.; Turek, C.; Campos, S.; Edwards, J.; Ferret, P.; Höfer, N.; Kosemund, K.; Schnabel, J.; Ravenzwaay, B. van; Hollnagel, H.M.:
Thresholds of toxicological concern - overview of ongoing scientific developments. (European Societies of Toxicology (EUROTOX Congress) <52, 2016, Seville>)
Toxicology letters, Vol.258 (2016), Supplement, pp.S58
info:doi/10.1016/j.toxlet.2016.06.1302
Fraunhofer ITEM


Koschmann, J.; Sewald, K.; Escher, S.E.:
Tierversuchsfreie Methoden in der Toxikologie : Neuer Ansatz zur Vorhersage der Giftigkeit eingeatmeter Chemikalien
Systembiologie.de, (2016), pp.32-35
Fraunhofer ITEM


Calverley, Peter M.A.; Könen-Bergmann, Michael; Richard, Frank; Bell, Susan; Hohlfeld, Jens M.:
Tiotropium respimat® versus hHndiHaler®: Comparison of bronchodilator efficacy of various doses in clinical trials
Advances in therapy, Vol.33 (2016), No.5, pp.786-793
urn:nbn:de:0011-n-4042545
info:doi/10.1007/s12325-016-0322-9
Volltext
Fraunhofer ITEM


Gužvić, M.; Klein, C.A.:
Towards prevention of metastatic prostate cancer: Recent molecular insights from the direct analysis of metastatic precursor cells
Translational Cancer Research, Vol.5 (2016), Supplement 2, pp.S182-S186
info:doi/10.21037/tcr.2016.07.28
Fraunhofer ITEM


Schwotzer, Daniela; Niehof, Monika; Hansen, Tanja; Schuchardt, Sven; Tillmann, Thomas; Ernst, Heinrich; Creutzenberg, Otto H.:
Toxicity of CeO2 nanoparticles estimated in a 90-day nose-only inhalation study. (Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie (Annual Meeting) <82, 2016, Berlin>)
Naunyn-Schmiedebergs archives of pharmacology, Vol.389 (2016), Supplement 1, pp.S51, Abstract 210
Fraunhofer ITEM


Schwotzer, D.; Niehof, M.; Hansen, T.; Tillmann, T.; Ernst, H.; Creutzenberg, O.:
Toxicity of cerium dioxide nanoparticles - effects from a 90-day inhalation study. (European Societies of Toxicology (EUROTOX Congress) <52, 2016, Seville>)
Toxicology letters, Vol.258 (2016), Supplement, pp.S55
info:doi/10.1016/j.toxlet.2016.06.1292
Fraunhofer ITEM


Delgado, S.M.J.; Obernolte, H.; Hobbie, S.; Schindler, S.; Jonigk, D.; Warnecke, G.; Braubach, P.; Bersch, C.; Pfennig, O.; Fieguth, H.G.; Sewald, K.; Braun, A.:
Transient Receptor Potential (TRP) ion channels activation in vital human precision-cut lung slices lead to bronchoconstriction and is neuropeptide substance P-dependent. (American Thoracic Society (ATS International Conference) <2016, San Francisco/Calif.>)
American Journal of Respiratory and Critical Care Medicine, Vol.193 (2016), Art. A1342
Fraunhofer ITEM


Creutzenberg, Otto H.; Kock, Heiko; Schaudien, Dirk:
Translocation and biokinetic behavior of nanoscaled europium oxide particles within 5 days following an acute inhalation in rats
Journal of applied physiology, Vol.36 (2016), No.3, pp.474-478
info:doi/10.1002/jat.3259
Fraunhofer ITEM Z 1


Brodbeck, C.; Wolf, K.; Ritter, D.; Knebel, J.:
Use of computational fluid dynamics for optimization of cell-based in vitro methods in inhalation research. (European Societies of Toxicology (EUROTOX Congress) <52, 2016, Seville>)
Toxicology letters, Vol.258 (2016), Supplement, pp.S141
info:doi/10.1016/j.toxlet.2016.06.1550
Fraunhofer SCAI
Fraunhofer ITEM


Loza, M.J.; Djukanovic, R.; Chung, K.F.; Horowitz, D.; Ma, K.; Branigan, P.; Barnathan, E.S.; Susulic, V.S.; Silkoff, P.E.; Sterk, P.J.; Baribaud, F.; Badorrek, P.; Faulenbach, C.; Braun, A.; Hohlfeld, J.; Krug, N.; et. al.:
Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study
Respiratory research. Online journal, Vol.17 (2016), Art. 165, 21 pp.
info:doi/10.1186/s12931-016-0482-9
Fraunhofer ITEM


Uhde, Ann-Kathrin; Herder, Vanessa; Akram Khan, Muhammad; Ciurkiewicz, Malgorzata; Schaudien, Dirk; Teich, Rene; Floess, Stefan; Baumgärtner, Wolfgang; Huehn, Jochen; Beineke, Andreas:
Viral infection of the central nervous system exacerbates interleukin-10 receptor deficiency-mediated colitis in SJL mice
PLoS one. Online journal, Vol.11 (2016), No.9, Art. e0161883, 36 pp.
info:doi/10.1371/journal.pone.0161883
Fraunhofer ITEM


Fernando, Ruani N.; Chaudhari, Umesh; Escher, Sylvia E.; Hengstler, Jan G.; Hescheler, Jürgen; Jennings, Paul; Keun, Hector C.; Kleinjans, Jos C.S.; Kolde, Raivo; Kollipara, Laxmikanth; Kopp-Schneider, Annette; Limonciel, Alice; Nemade, Harshal; Nguemo, Filomain; Peterson, Hedi; Prieto, Pilar; Rodrigues, Robim M.; Sachinidis, Agapios; Schäfer, Christoph; Sickmann, Albert; Spitkovsky, Dimitry; Stöber, Regina M.; Breda, Simone G.J. van; Water, Bob van de; Vivier, Manon; Zahedi, Rene P.; Vinken, Mathieu; Rogiers, Vera:
"Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015
Archives of toxicology, Vol.90 (2016), No.6, pp.1529-1539
info:doi/10.1007/s00204-016-1719-6
Fraunhofer ITEM