Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2011Advanced computational biology methods identify molecular switches for malignancy in an EGF mouse model of liver cancer
Stegmaier, P.; Voss, N.; Meier, T.; Kel, A.; Wingender, E.; Borlak, J.
Journal Article
2011Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma
Zoerner, A.A.; Stichtenoth, D.O.; Engeli, S.; Batkai, S.; Winkler, Carla; Schaumann, Frank; Janke, J.; Holz, Olaf; Krug, Norbert; Tsikas, D.; Jordan, J.; Hohlfeld, Jens Michael
Journal Article
2011Animal studies on RF EMF cancer effects
Dasenbrock, C.; Buschmann, J.
Book Article
2011Anti-allergic drug testing in an environmental challenge chamber is suitable both in and out of the relevant pollen season
Badorrek, P.; Dick, M.; Hecker, H.; Schaumann, F.; Hohlfeld, J.M.; Krug, N.; Sousa, A.R.; Murdoch, R.
Journal Article
2011Antibody production in bacillus megaterium: Strategies and physiological implications of scaling from microtiter plates to industrial bioreactors
David, Florian; Steinwand, Miriam; Hust, Michael; Bohle, Kathrin; Ross, Anton; Dübel, Stefan; Franco-Lara, Ezequiel
Journal Article
2011Breath profiles by electronic nose correlate with systemic markers but not ozone response
Biller, Heike; Holz, Olaf; Windt, Horst; Koch, Wolfgang; Müller, Meike; Jörres, Rudolf A.; Krug, Norbert; Hohlfeld, Jens M.
Journal Article
2011Bronchoconstriction in nonhuman primates: A species comparison
Seehase, S.; Schlepütz, M.; Switalla, S.; Mätz-Rensing, K.; Kaup, F.J.; Zöller, M.; Schlumbohm, C.; Fuchs, E.; Lauenstein, H.-D.; Winkler, C.; Kuehl, A.R.; Uhlig, S.; Braun, A.; Sewald, K.; Martin, C.
Journal Article
2011Cancer proteomics of mouse serum and liver tissue samples to discover candidate biomarkers for hepatocellular carcinoma (HCC) in c-Myc transgenic mice
Ritorto, Maria Stella
: Borlak, Jürgen (Referent); Alves, Juergen (Korreferent)
Dissertation
2011CD4(+)CD25(+)Foxp3(+) regulatory T cells are dispensable for controlling CD8(+) T cell-mediatedl lung inflammation
Tosiek, Milena J.; Gruber, Achim D.; Bader, Sophie R.; Mauel, Susanne; Hoymann, Heinz-Gerd; Prettin, Silvia; Tschernig, Thomas; Buer, Jan; Gereke, Marcus; Bruder, Dunja
Journal Article
2011Characterization of local respiratory irritation and inflammation after acute exposure to biological and chemical substances in PCLS
Switalla, S.
: Steinhagen, D. (Referent); Braun, Armin (Korreferent); Bicker, Gerd (Korreferent)
Dissertation
2011Cholinergic chemosensory cells in the trachea regulate breathing
Krasteva, G.; Canning, B.J.; Hartmann, P.; Veres, T.Z.; Papadakis, T.; Mühlfeld, C.; Schliecker, K.; Tallini, Y.N.; Braun, A.; Hackstein, H.; Baal, N.; Weihe, E.; Schütz, B.; Kotlikoff, M.; Ibanez-Tallon, I.; Kummer, W.
Journal Article
2011Combined serum and tissue proteomic study applied to a c-Myc transgenic mouse model of hepatocellular carcinoma identified novel disease regulated proteins suitable for diagnosis and therapeutic intervention strategies
Ritorto, M.S.; Borlak, J.
Journal Article
2011Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD
Winkler, C.; Atochina-Vasserman, E.N.; Holz, O.; Beers, M.F.; Erpenbeck, V.J.; Krug, N.; Roepcke, S.; Lauer, G.; Elmlinger, M.; Hohlfeld, J.M.
Journal Article
2011Correlation versus causation? Pharmacovigilance of the analgesic flupirtine exemplifies the need for refined spontaneous adr reporting
Anderson, N.; Borlak, J.
Journal Article
2011Development of a strategy for constitution of categories and defining new categories for the end points subacute, subchronical and chronical toxicity to minimize animal testing under REACH
Gundert-Remy, U.; Partosch, F.; Stahlmann, R.; Bitsch, Annette; Weiss, Sara
Conference Paper, Journal Article
2011Development of MALDI-TOF mass spectrometry based methods for the identification and molecular characterization of proteins, phosphoproteins and DNA adducts
Garaguso, Ignazio
: Borlak, Jürgen (Referent); Pich, Andreas (Korreferent)
Dissertation
2011Discrepancy between high clastogenic activity of trans-beta-nitrostyrene in vitro and lack in carcinogenicity might be related to inactivating metabolism and its high reactivity towards thiol groups
Ziemann, Christina; Apitius, Florian; Elend, Manfred; Baumgartner, S.; Volk, J.; Ritter, Detlef; Steinfelder, H.J.; Schuchardt, Sven
Conference Paper, Journal Article
2011Effect of acute ozone induced airway inflammation on human sympathetic nerve traffic: A randomized, placebo controlled, crossover study
Tank, J.; Biller, H.; Heusser, K.; Holz, O.; Diedrich, A.; Framke, T.; Koch, A.; Grosshennig, A.; Koch, W.; Krug, N.; Jordan, J.; Hohlfeld, J.M.
Journal Article
2011The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge
Nicholson, G.C.; Kariyawasam, H.H.; Tan, A.J.; Hohlfeld, J.M.; Quinn, D.; Walker, C.; Rodman, D.; Westwick, J.; Jurcevic, S.; Kon, O.M.; Barnes, P.J.; Krug, N.; Hansel, T.T.
Journal Article
2011Environmental properties and aquatic hazard assessment of anionic surfactants: Physico-chemical, environmental fate and ecotoxicity properties
Könnecker, G.; Regelmann, J.; Belanger, S.; Gamon, K.; Sedlak, R.
Journal Article
2011Evaluation of reproductive/developmental and repeated dose (subchronic) toxicity and cytogenetic effects in rats of a roofing asphalt fume condensate by nose-only inhalation
Parker, C.M.; Schreiner, C.A.; Hallmark, N.; Kriech, A.J.; Osborn, L.V.; Fuhst, R.; Buschmann, J.; Ernst, H.; Hansen, T.; Pohlmann, G.; Preiß, A.; Ziemann, C.
Journal Article
2011Evaluation of time extrapolation factors based on the database RepDose
Batke, M.; Escher, S.; Hoffmann-Doerr, S.; Melber, C.; Messinger, H.; Mangelsdorf, I.
Journal Article
2011Fraunhofer-Institut für Toxikologie und Experimentelle Medizin. Leistungen und Ergebnisse. Jahresbericht 2010
 
Annual Report
2011Functional role of lysosomal proteases in allergic airway inflammation
Pilzner, C.
: Groneberg, D.; Welte, T.; Braun, A.
Dissertation
2011Gene targeting of the cysteine peptidase cathepsin H impairs lung surfactant in mice
Bühling, F.; Kouadio, M.; Chwieralski, C.E.; Kern, U.; Hohlfeld, J.M.; Klemm, N.; Friedrichs, N.; Roth, W.; Deussing, J.M.; Peters, C.; Reinheckel, T.
Journal Article
2011Genotoxic mode of action of fine and ultrafine dusts in lungs
Creutzenberg, Otto
Report
2011High dose of dietary resveratrol enhances insulin sensitivity in healthy rats but does not lead to metabolite concentrations effective for SIRT1 expression
Andersen, G.; Burkon, A.; Sulzmaier, F.J.; Walker, J.M.; Leckband, G.; Fuhst, R.; Erbersdobler, H.F.; Somoza, V.
Journal Article
2011A high resolution genome-wide scan of HNF4alpha recognition sites infers a regulatory gene network in colon cancer
Weltmeier, F.; Borlak, J.
Journal Article
2011Histologische und elektronenmikroskopische Untersuchungen der Lunge nach Inhalation von Titandioxid-Nanopartikeln bzw. -Feinpartikeln bei der Ratte
Eydner, M.
: Baumgärtner, W.; Pfarrer, C.
Dissertation
2011HNF4alpha dysfunction as a molecular rational for cyclosporine induced hypertension
Niehof, M.; Borlak, J.
Journal Article
2011Human Alveolar Epithelial Cells are a Target for Bacillus Anthracis
Metcalf, J.; Langer, M.; Booth, J.; Duggan, E.; Patel, V.; Veres, T.; Prenzler, F.; Sewald, K.; Braun, A.; Coggeshall, K.
Abstract
2011Improvement of experimental methods for toxicological characterization of inhalable substances in vitro by in situ analysis of the cellular status based on fluorescence stainings
Ritter, Detlef; Knebel, Jan
Conference Paper, Journal Article
2011Improvement of the Cramer classification for oral exposure using the database TTC RepDose - A strategy description
Tluczkiewicz, I.; Buist, H.E.; Martin, M.T.; Mangelsdorf, I.; Escher, S.E.
Journal Article
2011An international project to confirm soviet-era results on immunological and teratological effects of RF field exposure in wistar rats and comments on grigoriev et al. [2010]
Repacholi, M.; Buschmann, J.; Pioli, C.; Sypniewska, R.
Journal Article
2011Krankheiten erriechen? Eine kurze Übersicht über elektronische Nasen
Koczulla, A.R.; Hattesohl, A.; Biller, H.; Hofbauer, J.; Hohlfeld, J.; Oeser, C.; Gessner, C.; Vogelmeier, C.; Baumbach, J.I.; Wirtz, H.; Jörres, R.A.
Journal Article
2011Local treatment with BPPcysMPEG reduces allergic airway inflammation in sensitized mice
Knothe, S.; Mutschler, V.; Rochlitzer, S.; Winkler, C.; Ebensen, T.; Guzman, C.A.; Hohlfeld, J.; Braun, A.; Müller, M.
Journal Article
2011Mechanisms of bronchoconstriction in precision-cut lung slices of non-human primates are comparable to human
Seehase, Sophie; Schlepütz, M.; Switalla, Simone; Fuchs, E.; Kaup, F.-J.; Ressmeyer, A.R.; Uhlig, S.; Lauenstein, Hans-Dieter; Braun, Armin; Martin, C.; Sewald, Katherina
Conference Paper, Journal Article
2011Myosin-5, kinesin-1 and myosin-17 cooperate in secretion of fungal chitin synthase
Schuster, M.; Treitschke, S.; Kilaru, S.; Molloy, J.; Harmer, N.J.; Steinberg, G.
Journal Article
2011Neuronale Kontrolle bei chronisch entzündlichen und obstruktiven Lungenerkrankungen wie Asthma bronchiale und COPD
Dinh, Q.T.; Suhling, H.; Fischer, A.; Braun, Armin; Welte, Tobias
Journal Article
2011The neuropeptide calcitonin gene-related peptide affects allergic airway inflammation by modulating dendritic cell function
Rochlitzer, Sabine; Veres, Tibor Z.; Kühne, Kathleen; Prenzler, Frauke; Pilzner, Carolin; Knothe, Saskia; Winkler, Carla; Lauenstein, Hans-Dieter; Willart, M.; Hammad, H.; Müller, Meike; Krug, Norbert; Lambrecht, Bart N.; Braun, Armin
Journal Article
2011Nitrostyrolderivate als potentielle neue Zytostatika in der Therapie von Leukämien?
Baumgartner, S.
: Ziemann, Christina (Betreuer); Reinhardt, Dirk (Betreuer)
Dissertation
2011The NKT cell ligand alpha-galactosylceramide suppresses allergic airway inflammation by induction of a Th1 response
Knothe, Saskia; Mutschler, Vanessa; Rochlitzer, Sabine; Winkler, Carla; Ebensen, Thomas; Guzman, Carlos A.; Hohlfeld, Jens; Braun, A.; Muller, M.
Journal Article
2011Novel adenoviruses in wild primates: A high level of genetic diversity and evidence of zoonotic transmissions
Wevers, D.; Metzger, S.; Babweteera, F.; Bieberbach, M.; Boesch, C.; Cameron, K.; Couacy-Hymann, E.; Cranfield, M.; Gray, M.; Harris, L.A.; Head, J.; Jeffery, K.; Knauf, S.; Lankester, F.; Leendertz, S.A.J.; Lonsdorf, E.; Mugisha, L.; Nitsche, A.; Reed, P.; Robbins, M.; Travis, D.A.; Zommers, Z.; Leendertz, F.H.; Ehlers, B.
Journal Article
2011Pathology of flupirtine-induced liver injury: A histological and clinical study of six cases
Puls, F.; Agne, C.; Klein, F.; Koch, M.; Rifai, K.; Manns, M.P.; Borlak, J.; Kreipe, H.H.
Journal Article
2011PCLS: From learning about 'in vivo' to reduction and replacement
Sewald, Katherina; Braun, Armin
Book Article
2011Phantom and cadaver measurements of dose and dose distribution in micro-CT of the chest in mice
Rodt, Thomas; Luepke, Matthias; Boehm, Claudia; Falck, Christian von; Stamm, Georg; Borlak, Jürgen; Seifert, Hermann; Galanski, Michael
Journal Article
2011The phosphodiesterase-4-inhibitor Roflumilast reduces LPS-induced lung inflammation in common marmoset monkeys
Seehase, Sophie; Switalla, Simone; Prenzler, Frauke; Fuchs, E.; Schlumbohm, C.; Kaup, F.-J.; Sewald, Katherina; Lauenstein, Hans-Dieter; Braun, Armin
Conference Paper, Journal Article
2011Physicochemical characterisation of different welding aerosols
Berlinger, B.; Benker, N.; Weinbruch, S.; L'Vov, B.; Ebert, M.; Koch, Wolfgang; Ellingsen, D.G.; Thomassen, Y.
Journal Article
2011Pituitary adenylate cyclase-activating peptide receptor 1 mediates anti-inflammatory effects in allergic airway inflammation in mice
Lauenstein, H.D.; Quarcoo, D.; Plappert, L.; Schleh, C.; Nassimi, M.; Pilzner, C.; Rochlitzer, S.; Brabet, P.; Welte, T.; Hoymann, H.G.; Krug, N.; Müller, M.; Lerner, E.A.; Braun, A.; Groneberg, D.A.
Journal Article
2011Plasmid DNA production for pharmaceutical use: Role of specific growth rate and impact on process design
Bohle, Katrin; Ross, Anton
Journal Article
2011Prävalidierungsstudie zur Prüfung der toxischen Wirkung von inhalativ wirksamen Stoffen (Gase)
Knebel, Jan; Ritter, Detlef; Berger-Preiß, Edith; Kock, Heiko; Liebsch, Manfred; Smirnova, Lena; Pirow, Ralph; Linsel, Gunter; Bauer, Mario; Graebsch, Carolin
Study
2011Process development for production of pharmaceutical grade plasmid DNA to be used in gene therapy and DNA vaccination
Luer, C.; Bohle, K.; Ross, A.; Ziehr, H.
Abstract
2011Produktion, Aufreinigung und Validierung eines monoklonalen anti-EpCAM-Antikörpers
Neß, Melanie
: Pfitzner, Reinhard (Betreuer); Borlak, Jürgen (Betreuer)
Bachelor Thesis
2011Quantification of the unknown HONO daytime source and its relation to NO(2)
Sorgel, M.; Regelin, E.; Bozem, H.; Diesch, J.M.; Drewnick, F.; Fischer, H.; Harder, H.; Held, A.; Hosaynali-Beygi, Z.; Martinez, M.; Zetzsch, C.
Journal Article
2011Quantification of the unknown HONO daytime source and its relation to NO2
Sörgel, M.; Regelin, E.; Bozem, H.; Diesch, J.-M.; Drewnick, F.; Fischer, H.; Harder, H.; Held, A.; Hosaynali-Beygi, Z.; Martinez, M.; Zetzsch, C.
Journal Article
2011Relationship of pulmonary toxicity and carcinogenicity of fine and ultrafine granular dusts in a rat bioassay
Kolling, A.; Ernst, H.; Rittinghausen, S.; Heinrich, U.
Journal Article
2011Research recommendations toward a better understanding of the causes of childhood leukemia
Ziegelberger, G.; Baum, C.; Borkhardt, A.; Cobaleda, C.; Dasenbrock, C.; Dehos, A.; Grosche, B.; Hauer, J.; Hornhardt, S.; Jung, T.; Kammertoens, T.; Lagroye, I.; Lehrach, H.; Lightfoot, T.; Little, M.P.; Rossig, C.; Sanchez-Garcia, I.; Schrappe, M.; Schuez, J.; Shalapour, S.; Slany, R.; Stanulla, M.; Weiss, W.
Journal Article
2011Respiratory sensitization: Advances in assessing the risk of respiratory inflammation and irritation
Vandebriel, Rob; Cransveld, Conchita Callant; Crommelin, Daan; Diamant, Zuzana; Glazenburg, Berend; Joos, Guy; Kuper, Frieke; Natsch, Andreas; Nijkamp, Frans; Noteborn, Hub; Pieters, Raymond; Roberts, David; Roggen, Erwin; Rorije, Emiel; Seed, Martin; Sewald, Katharina; Heuvel, Rosette van den; Engelen, Jacqueline van; Verstraelen, Sandra; Loveren, Henk van
Journal Article
2011RITA - Registry of Industrial Toxicology Animal data: The application of historical control data for Leydig cell tumors in rats
Nolte, T.; Rittinghausen, S.; Kellner, R.; Karbe, E.; Kittel, B.; Rinke, M.; Deschl, U.
Journal Article
2011Segmental allergen challenge alters multimeric structure and function of surfactant protein D in humans
Atochina-Vasserman, E.N.; Winkler, C.; Abramova, H.; Schaumann, F.; Krug, N.; Gow, A.J.; Beers, M.F.; Hohlfeld, J.M.
Journal Article
2011Simultaneous HONO measurements in and above a forest canopy: Influence of turbulent exchange on mixing ratio differences
Sörgel, M.; Trebs, I.; Serafimovich, A.; Moravek, A.; Held, A.; Zetzsch, C.
Journal Article
2011Single cell detection of latent cytomegalovirus reactivation in host tissue
Marquardt, A.; Halle, S.; Seckert, C.K.; Lemmermann, N.A.W.; Veres, T.Z.; Braun, A.; Maus, U.A.; Förster, R.; Reddehase, M.J.; Messerle, M.; Busche, A.
Journal Article
2011Spatiotemporal and functional behavior of airway dendritic cells visualized by two-photon microscopy
Veres, Tibor Z.; Voedisch, Sabrina; Spies, Emma; Tschernig, Thomas; Braun, Armin
Journal Article
2011Spinal epidermoid cyst in a SJL mouse: Case report and literature review
Hansmann, F.; Herder, V.; Ernst, H.; Baumgärtner, W.
Journal Article
2011T(H)17 cells mediate pulmonary collateral priming
Albrecht, Melanie; Chen, Hui-Chen; Preston-Hurlburt, Paula; Ranney, Patricia; Hoymann, Heinz-Gerd; Maxeiner, Joachim; Staudt, Valérie; Taube, Christian; Bottomly, H. Kim; Dittrich, Anna-Maria
Journal Article
2011Testung von Consumer-Sprays in der isoliert perfundierten Lunge der Ratte
Fischer, M.
: Hackbarth, H.; Kietzmann, M.; Dasenbrock, C.
Dissertation
2011TLR agonist mediated suppression of allergic responses is associated with increased innate inflammation in the airways
Düchs, M.J.; Hahn, C.; Benediktus, E.; Werner-Klein, M.; Braun, A.; Hoymann, H.G.; Gantner, F.; Erb, K.J.
Journal Article
2011Toxicological characterization of inhalable substances and aerosols in vitro: Enhancement of experimental methods by in situ fluorescence analysis of the cellular status during exposure
Ritter, Detlef; Knebel, Jan
Journal Article, Conference Paper
2011Toxicological properties and risk assessment of the anionic surfactants category: Alkyl sulfates, primary alkane sulfonates, and alpha-olefin sulfonates
Wibbertmann, A.; Mangelsdorf, I.; Gamon, K.; Sedlak, R.
Journal Article
2011Toxikologische Bewertung von Extractables & Leachables: Wie kann die Sicherheit der Patienten gewährleistet werden?
Licht, O.; Wibbertmann, A.
Conference Paper
2011Untersuchungen zum biologischen Effekt inhalierbarer Aerosole in vitro
Lange, Carsten
: Scharfenberg, Klaus (Erstprüfer); Dasenbrock, Clemens (Zweitprüfer); Knebel, Jan (Betreuer); Ritter, Detlef (Betreuer)
Bachelor Thesis
2011Unusual polar metabolites in the groundwater of a contaminated waste site indicate a new pathway of mononitrotoluene transformation
Preiss, Alfred; Berger-Preiss, Edith; Elend, Manfred; Reineke, Anne-Kirsten; Hollender, Juliane
Journal Article
2011Use of Perboric Acid, Sodium Salt (PBS) - Has REACH improved our state of knowledge on the risk for the aquatic environment?
Könnecker, Gustav; Regelmann, Jürgen; Grcar, Marko
Poster
2011Validation of an EDP-supported model for assessing inhalation exposure during indoor spraying processes
Berger-Preiß, Edith; Behnke, Wolfgang; Hahn, Stefan; Kock, Heiko; Gerling, Susanne; Schröder, Katrin; Koch, Wolfgang
Conference Paper
2011Verfahren umweltbezogener gesundheitlicher Stoffbewertungen
Licht, Oliver; Mangelsdorf, Inge
: Voss, Jens-Uwe (Mitarb.)
Study
2011Vergleich von vier baugleichen elektronischen Nasen und drei Messaufbauten
Koczulla, A.R.; Hattesohl, A.; Biller, H.; Hofbauer, J.; Hohlfeld, J.; Oeser, C.; Wirtz, H.; Jörres, R.A.
Journal Article
2011WHO/IPCS Harmonization Project: A structured approach for interpretation of effects in toxicity studies that may be modest or adaptive
Dobrev, I.; Melber, C.; Mangelsdorf, I.
Abstract