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The determination of trifluoroacetic acid in rat milk samples by 19F-NMR spectroscopy and capillary gas chromatography

: Preiß, A.; Kruppa, J.; Buschmann, J.; Mügge, C.


Journal of pharmaceutical and biomedical analysis 16 (1998), S.1381-1385
ISSN: 0731-7085
Fraunhofer ITA ( ITEM) ()
analytical chemistry; Clinical chemistry; gas chromatography; Hydrochlorofluorocarbons; milk; molecular spectroscopy; rat; Trifluoroacetic acid

The 19F-NMR spectroscopy provides a specific method for the identification and quantification of TFA in biological matrices. [...] In our investigation, calibration curves were obtained by integrating 19F-NMR signals of the spiked rat milk samples and plotting the peak against the known concentration of TFA in the standard samples. Then, the peak areas of the corresponding 19F-NMR signal in the study samples were interpolated against these calibration curves to calculate the TFA concentrations present. In this way, recovery experiments were not necessary. [...] (Citated from 3. Results and discussion)