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Co-recombinogenic and co- or anti-mutagenic effects of non-genotoxic carcinogens in S. cerevisiae MP1

: Fahrig, R.

Journal of environmental pathology, toxicology and oncology 16 (1997), Nr.4, S.273-279
ISSN: 0146-4779
ISSN: 0731-8898
Fraunhofer ITA ( ITEM) ()
Antimutagens; Carcinogenesis; Carcinogens; genetic recombination; genetic toxicology; mutagenesis; mutagenicity testing; mutagens

Carcinogens are generally classified into two groups: genotoxic and non-genotoxic. As the final product of genotoxic and non-genotoxic carcinogens is the same, that is, a clone of genetically altered cells, it could be possible that non-genotoxic carcinogens may yield genotoxic events as a secondary result of cell toxicity having led to mitogenesis/cellular proliferation, or that genetic alterations are induced that are normally neglected in genotoxcicity tests. A genetic effect with possible relevance for the ultimate mechanism of carcinogenicity is recombination. In previous experimemts using yeast, bacteria, Drosophila or mice, tumor promoters were co-recombinogenic/anti-recombinogenic. (Abstract truncated)