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Cleft palates and liver weight data of two different mixtures of PCDDs in pregnant mice related to organ dosage



Chemosphere 25 (1992), Nr.7-10, S.1153-1157
ISSN: 0045-6535
ISSN: 0366-7111
International Symposium on Chlorinated Dioxins and Related Compounds (Dioxin) <11, 1991, Research Triangle Park>
Fraunhofer ITA ( ITEM) ()
biological chemistry; chemical; cleft palate; dioxin; environmental chemistry; environmental health; environmental toxicology; mouse; tetrachlorodibenzodioxin; toxicology

Three doses of two different mixtures of PCDD homologues and congeners were administered on day 9 of pregnancy to C57BL/6J (B6) or DBA/2J (D2) mice. Doses given to D2 mice were tenfold higher than those given to B6 mice. In addition, 2,3,7,8-TCDD was tested separately as well as in combination with the applied doses of the PCDD mixtures. On day 18 of pregnancy the mice were sacrificed, organ weight data were taken, and the number of fetuses with cleft palates was determined. Liver weight was significantly increased in all treated D2 mice, however, in B6 mice only when 2,3,7,8-TCDD was co-administered. The incidence of cleft palates were dose-dependent in the fetuses of D2 mice. In B6 mice this malformation occured either after the administration of 2,3,7,8-TCDD alone or with 2,3,7,8-TCDD added to the different PCDD mixtures.