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Ciclosporin A inhibits endothelium-dependent vasodilatation and vascular prostacyclin production

: Bossaller, C.; Fleck, E.; Förstermann, U.; Hertel, R.F.; Olbricht, C.; Reschke, V.

European Journal of Pharmacology 165 (1989), S.165-169
ISSN: 0014-2999
Fraunhofer ITA ( ITEM) ()
6-keto-PGF 1; Acetylcholine; Aorta; Ciclosporin A; Cyclosporin A; Endothelium; Glycery trinitrate; radioimmunoassay; rat

Aortic rings dissected from rats treated with ciclosporin A showed reduced relaxation induced by the endothelium dependent vasolidator acetylcholine, but unchanged responses induced by glyceryl trinitrate. After eight weeks of ciclosporin A treatment, the relaxation induced by both acetylcholine and glyceryl trinitrate was inhibited. In addition, phenylephrine-induced contractions were slightly enhanced and vascular prostacyclin production was reduced by more than 80%. These effects may participate in the hypertensive and thrombo-embolic complications associated with the clinical use of ciclosporin A.