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Chronic inhalation toxicity and carcinogenicity of 4,4-methylenediphenyldiisocyanate (MDI) in rats


Naunyn-Schmiedebergs archives of pharmacology 355 (1997), Nr.4, Suppl., Nr.564 (Abstract)
ISSN: 0028-1298
ISSN: 1432-1912
Fraunhofer ITA ( ITEM) ()
4,4'-methylenediphenyldiisocyanate; inhalation toxicology; rat

Female Wistar rats were exposed in 6 m³ id groups and in increase in maternal lung weight in the high dose group. Consequently, a "no embryotoxic effect level" of 3 mg/m³ was determined. MDI metabolites occured in decreasing concentrations in the placenta, the fetus and the amniotic fluid.
Further investigations are necessary to clarify the mechanism of the MDI-dependent tumor induction in the respiratory tract of the rat.