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Title
Tumorsuppressorgene der p53-Familie
Date Issued
2000
Author(s)
Schmale, H.
Bamberger, C.
Paul, D.
Augustin, M.
Patent No
1998-19822985
Abstract
Die Erfindung betrifft neue Tumorsuppressorgene der p53-Familie, Polypeptide, die sie kodieren sowie ihre Verwendung. Bevorzugt betrifft sie KET-kodierende Nukleinsaeuren, insbesondere der Ratte, des Menschen und der Maus.
WO 9961610 A UPAB: 20000128 NOVELTY - KET-encoding nucleic acid (I) and its fragments, variants and mutants. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for the following: (1) polypeptides (II) encoded by (I); (2) vector containing (I); (3) host cells containing this vector; and (4) test kits for detecting or altering (I) containing at least one (I), (II) or hybridization probe. ACTIVITY - Anticancer. MECHANISM OF ACTION - (I) encodes a protein, (II), involved in control of the cell cycle and apoptosis, i.e. (II) is a tumor suppressor. USE - (I), and the polypeptide (II) encoded by it, are used (a) to detect (I) in biological samples, specifically angiogenic tumor tissue, including (I) sequences that have a homozygotic deletion and (b) to detect presence or absence of human chromosome 3q27 or murine chromosome 16, or their fragments, by hybridization. Also (not claimed), (I) is used as a tumor suppressor, particularly in tumors where an alteration in the wild-type p53 allele has not been identified. (I) and (II) may also be used for development of specific cytotoxic agents and for predicting the risk of developing cancer. ADVANTAGE - No advantages stated in the specification.
Language
de
Patenprio
DE 1998-19822985 A: 19980525