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Antimutagenic effects of tumor promoters - co-mutagenic effects of co-carcinogens

: Fahrig, R.

Antimutagenesis and Anticarcinogenesis Mechanisms II
New York/N.Y.: Plenum Press, 1990
ISBN: 0-306-43403-2
International Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis <2, 1988, Ohito>
Fraunhofer ITA ( ITEM) ()
antimutagenic effect; carcinogen; Carcinogenesis; carcinogenicity; co-carcinogenicity; genotoxic substance; mutagen; mutagenesis; mutagenicity; recombinogenicity; tumor promoter

The approach of this work was to investigate the influence of tumor promoters and co-carcinogens upon mutagenicity and recombinogenicity of genotoxic substances, using yeast strain MP1. Saccharomyces cerevisiae is a suitable organism in which to study mechanisms which result in the expression of a heterozygous recessive gene. Previous short-term experiments have shown that in stationary phase cells chromosome loss can be induced neither by tumor promoters and co-carcinogens alone, nor in combination with a carcinogen. In such experiments, tumor promoters were neither mutagenic nor recombinogenic when given alone; only a few co-carcinogens were weakly mutagenic.