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Anti-recombinogenic and convertible co-mutagenic effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted pyrimidine nucleoside analogs in S.cerevisiae MP1

: Fahrig, R.


Mutation research 372 (1996), Nr.1, S.133-139
ISSN: 0027-5107
Fraunhofer ITA ( ITEM) ()
Antimutagens; Bromodeoxyuridine; Carcinogenesis; cocarcinogenesis; Cocarcinogens; genetic recombination; mutagenesis; mutagenicity testing; mutation; Nucleosides; Pyrimidine nucleotides; Pyrimidines; saccharomyces; Uridine; yeast

In experiments using yeast without addition of an external metabolic activation system, ... BVDU was co-mutagenic and showed an insignificant anti-recombinogenic effect in combination with triethylene melamine (TEM). In the presence of activating S9-mix, the anti-recombinogenicity and co-mutagenicity could clearly be seen. At higher concentrations the co-mutagenic effect was converted into anti-mutagenicity. The other three 5-substituted pyrimidine nucleoside analogs were tested only in the presence of activating S9-mix and showed similar effects. As TEM is a direct alkylating agent that is inactivated by liver microsomes, the higher activity in presence of S9-mix can be interpreted as resulting from metabolic activation of the 5-substituted pyrimidine nucleoside analogs. (Abstract truncated)