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Urinary and faecal excretion of pyrene and hydroxypyrene by rats after oral, intraperitoneal, intratracheal or intrapulmonary application

: Jacob, J.; Brune, H.; Gettbarn, G.; Mohtashamipur, E.; Norpoth, K.; Wenzel-Hartung, R.; Heinrich, U.; Pott, F.

Cancer letters 46 (1989), Nr.1, S.15-20
ISSN: 0304-3835
ISSN: 1872-7980
Fraunhofer ITA ( ITEM) ()
1-hydroxypyrene; faecal excretion; feoes; gas chromatography; GC-MS; hydroxypyrene; mass spectrometry; matabolism; PAH; polycyclic aromatic hydrocarbon; pyrene; rat; urinary excretion

The urinary and faecal excretion of pyrene and 1-hydroxypyrene after oral (53,4 %), intraperitoneal (3,1 %), intratracheal (30-37 %) and intrapulmonary application (0,003 %) to rats has been determined by means of gas chromatography/mass spectrometry and the excretion rates were found to depend on the mode of application. With regard to the low urinary excretion rates, 1-hydroxyprene seems not to be very suitable as a biological marker for PAH exposure to man.